²⁰¹Tl-labeled Prussian blue and Au@Prussian blue nanoprobes for SPEC-CT imaging: influence of the size, shape and coating on the biodistribution

Abstract

201Tl-labeled Prussian blue and core@shell Au@Prussian blue nanoparticles coated with the phospholipidic bilayer and dextran were investigated in vivo as nanoprobes by usingSPECT-CT scintigraphy.

Fashioning Prussian Blue Nanoparticles by Adsorption of Luminophores: Synthesis, Properties, and in Vitro Imaging

“…Surfactant free PB nanoparticles Na 0.30 Fe III [Fe II (CN) 6 ] 0.82 ·3.7H 2 O ( 1 ) of 72 ± 6 nm (Figure S1) were obtained using our previously reported method of the controlled addition of the molecular precursors Na 4 [Fe­(CN) 6 ]·10H 2 O and FeCl 3 ·6H 2 O in aqueous solution. , 1 was subsequently redispersed in either ethanol or water with AA or RhB , respectively, and the mixture was reacted for 24 h before being thoroughly washed and next dialyzed to fully remove any residual luminophores. Elemental and thermogravimetric (TGA) analyses (Figures S2 and S3) on the obtained solids allow estimating the water and luminophores content to give Na 0.30 Fe III [Fe II (CN) 6 ] 0.83 @(AA) 0.08 ·3.6H 2 O ( 1@AA ) and Na 0.23 Fe III [Fe II (CN) 6 ] 0.81 @(RhB) 0.02 ·3.7H 2 O ( 1@RhB ).…”

“…The PB nanoparticles (NPs) were obtained following general procedures. , At 25 °C, aqueous solutions of FeCl 3 ·6H 2 O (10.00 mM, 10 mL) and Na 4 [Fe­(CN) 6 ]·10H 2 O (11.25 mM, 10 mL) were added simultaneously to 100 mL of pure water at a 2 mL·h –1 rate, using a syringe pump. After addition, the mixture was stirred 1 h before being centrifuged at 37 500 × g (20 000 rpm) during 15 min.…”

Prussian Blue Nanoparticles as a Versatile Photothermal Tool

“…This area has not yet been specifically reviewed and the present paper proposes to fill such gap. On the other hand different biomedical uses of PBnp have been reported, especially in the field of imaging [ 16 , 17 , 18 , 19 ] and drug delivery [ 16 , 20 , 21 , 22 , 23 ], that will not be reviewed in this paper. Finally, at this stage the so-called Prussian Blue analogs (PBA) have to be mentioned.…”

The design of magneto-plasmonic nanostructures formed by magnetic Prussian Blue-type nanocrystals decorated with Au nanoparticles

“…19 A second limitation of this procedure is that it is restricted to spherical Au NPs because anisotropic shapes (such as nanorods (NRs) or nanostars (NSs)) are too reactive towards cyanide. Still, these limitations have not been too problematic for using this kind of nanostructure in biomedicine (dual function NPs for imaging, photothermal therapy, or biosensing) 20,21 and electrocatalysis. 22,23 We propose here a simple and versatile approach to synthesize hybrid Au-PBA nanostructures formed by a PBA cubic NP surrounded by Au NPs of different shapes and connected through a bridging molecule.…”