<sup>211</sup>At on gold nanoparticles for targeted radionuclide therapy application

Tanudji, Jeffrey; Kasai, Hideaki; Okada, Michio; Ogawa, Tetsuo; Aspera, Susan M.; Nakanishi, Hiroshi

doi:10.1039/d3cp05326a

Phys. Chem. Chem. Phys.

2024

DOI: 10.1039/d3cp05326a

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²¹¹At on gold nanoparticles for targeted radionuclide therapy application

Jeffrey Tanudji,

Hideaki Kasai,

Michio Okada

et al.

Abstract: Targeted alpha therapy (TAT) is a methodology that is being developed as a promising cancer treatment using the alpha-particle decay of radionuclides. This technique involves the use of heavy radioactive...

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2024

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Cited by 2 publications

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Direct Labeling of Gold Nanoparticles with Iodine-131 for Tumor Radionuclide Therapy

Zhu,

Zhao,

2024

IJN

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Purpose Gold nanoparticles (Au NPs) are widely used as versatile templates to develop multifunctional nanosystems for disease diagnosis and treatment. Iodine can bind to gold via chemisorption, making this a simple method for labeling Au NPs with radioactive iodine. However, the evaluation of tumor radionuclide therapy is insufficient. In this study, we investigated the feasibility of 131 I-adsorbed Au NPs as novel nanoprobes for tumor radionuclide therapy. Materials and Methods Radiolabeling was performed by mixing Au NPs and 131 I, and the radiochemical purity (RCP) and in vitro stability of 131 I-adsorbed Au NPs were analyzed under different conditions, including various temperatures, pH values, and 131 I concentrations. The tumor accumulation and therapeutic potential of 131 I-adsorbed Au NPs were assessed using a subcutaneous tumor model after intratumoral injection. Results The data showed that the chemisorption of the Au NPs onto 131 I was instant, specific, and quantitative. The 131 I-adsorbed Au NPs exhibited high in vitro stability in different media, distinct inhibitory effects on tumor cells in vitro, good retention ability, and therapeutic effects after intratumoral injection into tumor-bearing mice in vivo. Conclusion Our work demonstrates that chemisorption of Au NPs and radioiodine has great potential as a strategy for constructing various nanosystems for theranostic applications.

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Direct Labeling of Gold Nanoparticles with Iodine-131 for Tumor Radionuclide Therapy

Zhu,

Zhao,

2024

IJN

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Development of LAT1-Selective Nuclear Medicine Therapeutics Using Astatine-211

Kaneda-Nakashima,

Shirakami,

Hisada

et al. 2024

IJMS

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We investigated nuclear medicine therapeutics targeting the L-type amino acid transporter 1 (LAT1). We previously reported that a nuclear medicine therapeutic drug using astatine 211 (211At), an alpha-emitting nuclide that can be produced in an accelerator and targets LAT1 as a molecular target, is effective. The seed compound was 3-[211At] Astato-α-methyl-L-tyrosine (211At-AAMT-OH-L). We used a unique labeling method. By changing the OH group of phenol to a methyl group, retention was successfully increased. It was also found that the amount of the L-isomer taken up by the D-isomer and L-isomer was clearly higher, and the L-isomer was superior as a therapeutic drug. Compounds in which the methyl group was replaced with an ethyl or propyl group were also examined, but their retention did not increase significantly. In fact, we observed increased non-specific accumulation and dynamics, suggesting that labeling may be off. In addition, 211At-AAMT-O-Me-L, which has a simple structure, was clearly superior in terms of uptake speed for several candidate compounds. As a result, we were able to develop a compound that can be easily labeled, has high specific radioactivity, is stable, and has a strong therapeutic effect.

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²¹¹At on gold nanoparticles for targeted radionuclide therapy application

Abstract: Targeted alpha therapy (TAT) is a methodology that is being developed as a promising cancer treatment using the alpha-particle decay of radionuclides. This technique involves the use of heavy radioactive...

Cited by 2 publications

References 142 publications

Direct Labeling of Gold Nanoparticles with Iodine-131 for Tumor Radionuclide Therapy

Direct Labeling of Gold Nanoparticles with Iodine-131 for Tumor Radionuclide Therapy

Development of LAT1-Selective Nuclear Medicine Therapeutics Using Astatine-211

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211At on gold nanoparticles for targeted radionuclide therapy application

Abstract: Targeted alpha therapy (TAT) is a methodology that is being developed as a promising cancer treatment using the alpha-particle decay of radionuclides. This technique involves the use of heavy radioactive...

Cited by 2 publications

References 142 publications

Direct Labeling of Gold Nanoparticles with Iodine-131 for Tumor Radionuclide Therapy

Direct Labeling of Gold Nanoparticles with Iodine-131 for Tumor Radionuclide Therapy

Development of LAT1-Selective Nuclear Medicine Therapeutics Using Astatine-211

Contact Info

Product

Resources

About

²¹¹At on gold nanoparticles for targeted radionuclide therapy application