1990
DOI: 10.1002/mrm.1910140304
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31P NMR studies of ATP concentrations and Pi–ATP exchange in the rat kidney in Vivo: Effects of inhibiting and stimulating renal metabolism

Abstract: Previous investigators found that cyanide (CN-) is a potent inhibitor of renal Na+ transport, while the uncoupling agent 2,4-dinitrophenol (DNP) and fructose (both which lower ATP levels) are weak transport inhibitors. To examine the disparate effects of these substances measurements of ATP were performed, using 31P NMR, while simultaneously monitoring renal Na+ transport. Infusion of CN-, DNP, and fructose lowered whole kidney ATP levels by about the same extent (30%) while only CN- inhibited Na+ transport. T… Show more

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Cited by 6 publications
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“…Spectra of remnant kidney were qualita tively similar to those of intact kidney [14][15][16][17][18], but several quantitative changes were seen. The relative intensities of both the P, and PME signals were significantly increased in remnant kidney.…”
Section: Discussionmentioning
confidence: 98%
“…Spectra of remnant kidney were qualita tively similar to those of intact kidney [14][15][16][17][18], but several quantitative changes were seen. The relative intensities of both the P, and PME signals were significantly increased in remnant kidney.…”
Section: Discussionmentioning
confidence: 98%