⁵⁷Fe Hyperfine Parameters in Vitamins and Dietary Supplements

Abstract

Mössbauer (nuclear gamma-resonance) spectroscopy was used to study various industrial samples of vitamins and dietary supplements containing iron ions, which are used in the anemia treatment. Determination of the iron state (Fe 2+ or Fe 3+ ) in medicaments is important for the pharmaceuticals evaluation quality. The investigated samples contain ferrous fumarate, ferrous gluconiate and ferric diphosphate. 57Fe hyperne parameters of the studied pharmaceuticals indicate that there exist major iron ferrous and ferric compounds. However, Mossbauer spectra of the investigated samples demonstrated the presence of additional ferrous and ferric components, probably related to impurities or to a partially modied main component.

Stability of Ferrous Fumarate in Medicaments for Women: Application of Mössbauer Spectroscopy

“…Apart from main component additional components related to the high spin ferric compound were observed in the Mössbauer spectra. Ferric ions accompanying ferrous iron compound contained in dietary supplements were also observed by other authors [3,[5][6][7][8]. All observed ferric components have similar hyperfine parameters, but their content is different in investigated medicaments.…”

“…Hyperfine parameters connected with particular subspectra are listed in Table I with experimental errors smaller than 5%. Previous Mössbauer data for ferrous fumarate were: Is in range from 1.16 mm/s to 1.24 mm/s and Qs in range from 2.18 mm/s to 2.24 mm/s [3,[5][6][7]. Hyperfine parameters of main component of all the investigated supplements correspond to ferrous fumarate.…”

Analyses of Ferrous and Ferric State in DynabiTabUsing Mössbauer Spectroscopy

“…These doublets show different values of quadrupole splitting (Δ E Q ) and isomer shifts ( δ ). Additional components connected with Fe 3+ in samples may be considered as an impurity or a result of ferrous gluconate oxidation and the formation of ferric gluconate [ 8 ].…”