1975
DOI: 10.1002/cncr.2820360906
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67Ga accumulation in pulmonary lesions associated with bleomycin toxicity

Abstract: The radionuclide, gallium‐67, accumulates in a wide variety of neoplastic and inflammatory lesions. Diffuse bilateral lung localization of67Ga occurred in two cases of interstitial pneumonitis associated with bleomycin therapy. Clinical symptoms and laboratory evaluation of pulmonary status correlated with scintigraphic studies in these two patients, while discrepancies between scinti‐graphic and roentgenographic findings were observed.Cancer 36:1966–1972,1975.

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Cited by 48 publications
(5 citation statements)
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“…6VGa scintigraphy has been useful in the early detection and assessment of the extent of pulmonary toxicity related to bleomycin [66] and nitrosourea [67], demonstrating areas of abnormal uptake not detectable by Xrays. Diffuse bilateral 67Ga uptake in the lungs, indicative of pulmonary toxicity, has also been observed in patients treated with chemotherapy including cyclophosphamide who had normal chest radiographs [68].…”
Section: Role Of 67ga In the Evaluation Of Pulmonary Complications Sementioning
confidence: 99%
“…6VGa scintigraphy has been useful in the early detection and assessment of the extent of pulmonary toxicity related to bleomycin [66] and nitrosourea [67], demonstrating areas of abnormal uptake not detectable by Xrays. Diffuse bilateral 67Ga uptake in the lungs, indicative of pulmonary toxicity, has also been observed in patients treated with chemotherapy including cyclophosphamide who had normal chest radiographs [68].…”
Section: Role Of 67ga In the Evaluation Of Pulmonary Complications Sementioning
confidence: 99%
“…The 67Ga scan is less sensitive than chest radiography in detecting lung metastases of tumors that have a tendency toward pulmonary dissemination, such as breast cancer (Richman 1975) and soft tissue sarcoma. A sensitivity of 84% is reported for metastatic melanoma.…”
Section: Detection Of Metastases Of Primary Extrapulmonary Tumormentioning
confidence: 99%
“…However, pulmonary manifestations of LE are generally mild. 67Ga has been used to assess pulmonary damage caused by pharmaceuticals such as nitrofurantoin (Crook 1982) or bleomycin (Richman 1975) and other antitumor drugs (McMahon 1978). Lung damage could be localized better by 67Ga than by chest radiography in most cases.…”
Section: Extrinsic Allergic Alveolitismentioning
confidence: 99%
“…Ga accumulates in the spine, pelvis, liver, and spleen, but it is not seen in normal lung tissue. Abnormal Ga uptake is, nevertheless, found in many lung disorders of varying pathogenesis, including bleomycin toxicity [6], pneumoconiosis [7], a variety of infectious and neoplastic disorders [2, 31, idiopathic pulmonary fibrosis [8], and granulomatous disease such as sarcoidosis [9]. In the latter two diseases, abnormal Ga scans have been related to the intensity of alveolitis consisting of accumulations of lymphocytes [ 10-121 and/or macrophages This study was designed to visualize Ga uptake through light microscopy of lung cells, using an experimental animal model in which alveolar and interstitial influxes of mononuclear cells were obtained.…”
Section: Introductionmentioning
confidence: 99%