⁶⁸ Ga-PSMA Positron Emission Tomography/Computerized Tomography for Primary Diagnosis of Prostate Cancer in Men with Contraindications to or Negative Multiparametric Magnetic Resonance Imaging: A Prospective Observational Study

Abstract

Our findings support the use of Ga labeled prostate specific membrane antigen positron emission tomography/computerized tomography for primary detection of prostate cancer in a specific subset of men.

Diagnostic accuracy of 68Ga‐prostate‐specific membrane antigen (PSMA) positron‐emission tomography (PET) and multiparametric (mp)MRI to detect intermediate‐grade intra‐prostatic prostate cancer using whole‐mount pathology: impact of the addition of 68Ga‐PSMA PET to mpMRI

“…This ability of PSMA‐PET to identify significant malignancy accurately in a cohort with ISUP grade 1–2 PCa is encouraging, suggesting it may be able to identify significant malignancy with a high degree of accuracy. This was recently confirmed in a small prospective cohort of patients with persistent suspicion for PCa, illustrating a higher diagnostic accuracy for patients with significant (Gleason score ≥7) disease vs patients with low‐risk (Gleason 6) disease ; however, the PPV was low (44%), suggesting that the criteria for a positive intra‐prostatic lesion on PSMA need to be optimized, including SUV max thresholds.…”

New Screening Test Improves Detection of Prostate Cancer Using Circulating Tumor Cells and Prostate-Specific Markers

“…First, not all screened men with positive PSMA-PET scans agreed to biopsies for confirmatory diagnosis of prostate cancer at the time of the study. However, the PSMA-PET scan has been shown to be a highly accurate, less invasive diagnostic tool with high sensitivity and specificity, useful in the detection of prostate cancer, especially in lower risk men reluctant to undergo biopsy (35)(36)(37)(39)(40)(41).…”

“…In a study of men with persistently elevated prostate PSA levels but negative digital rectal examination and negative biopsy, Ga 68 PSMA-PET guided biopsy was found to be useful in identifying clinically significant primary prostate cancer (Gleason ≥ 7), with 100% overall sensitivity, and 76-88% specificity (36).…”

Combination of 68Ga-PSMA PET/CT and Multiparametric MRI Improves the Detection of Clinically Significant Prostate Cancer: A Lesion-by-Lesion Analysis

“…68 Ga-labeled molecular imaging with PET-targeted prostate-specific membrane antigen ( 68 Ga-PSMA PET) is a relatively new nuclear imaging modality showing high sensitivity and specificity, initially proposed to identify locations of recurrent PCa (13)(14)(15)(16). Recently, several studies have investigated the role of 68 Ga-PSMA PET/CT in a first-line diagnostic setting also (17)(18)(19)(20), and some have investigated the role of simultaneous PET/MRI in PCa detection, concluding that it may further improve diagnostic accuracy in terms of cancer detection and gross volume estimation (21)(22)(23)(24).…”