<sup>7</sup>Li‐NMR and FTIR studies of lithium, potassium, rubidium, and cesium complexes with ionophore lasalocid in solution

Pankiewicz, Radosław; Schroeder, Grzegorz; Gierczyk, Błażej; Wojciechowski, Grzegorz; Brzeziński, Bogumił; Bartl, Franz; Zuńdel, Georg

doi:10.1002/bip.1012

Cited by 12 publications

(5 citation statements)

References 41 publications

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“…This means that the presence of the oxaalkyl chain affects the complex formation, especially with the Na + cations. In earlier studies the formation of 2:2 Na + lasalocid complexes was found 39, 40…”

Section: Resultsmentioning

confidence: 91%

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Multinuclear NMR and FTIR studies of new polyoxaalkyl esters of lasalocid and their complexes with lithium and sodium cations

et al. 2002

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Three new polyoxaalkyl esters of lasalocid are synthesized. Their ability to form complexes with Li(+) and Na(+) cations is studied using multinuclear NMR methods, FTIR spectroscopy in the middle and far IR regions, and mass spectrometry. It is found that lasalocid esters form only 1:1 complexes with the metal cations. The results of the NMR study in pyridine show that the polyoxaalkyl chain of the ester does not influence the complex formation of the lasalocid part of the esters. The reason for this is the competition of the pyridine molecules in the complexation process of metal cations. In chloroform the properties of the complex formation have changed and the oxaalkyl chain plays an important role within the complexation process, as demonstrated by the dependence of the respective continuous absorptions in the far IR region on the length of the oxaalkyl chain (i.e., on the number of the oxygen atoms in the chain). The modifications of the lasalocid molecule influences the complexation of the metal cation and probably the interactions with the membrane. An increase in antibiotic activity is found as a consequence of these changed interactions.

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Section: Resultsmentioning

confidence: 91%

“…We recently studied the nature of the complexes between lasalocid and monovalent cations by 7 Li‐NMR, 23 Na‐NMR, and FTIR spectroscopy 39, 40. In chloroform the formation of a 1:1 complex of lasalocid with Li + ions and 2:2 complexes of lasalocid with Na + , K + , Rb + , and Cs + ions was established.…”

Section: Introductionmentioning

confidence: 99%

Multinuclear NMR and FTIR studies of new polyoxaalkyl esters of lasalocid and their complexes with lithium and sodium cations

et al. 2002

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“…In the spectrum of the lithium cation complex, we observe a shift in the absorption maximum towards lower wavenumbers by 4 cm −1 . This shift is slightly larger than those of the other cations, but still small compared to those of the other lasalocid acid esters studied earlier [9,11]. This shows that, in the case of such strongly hydrophilic derivatives of lasalocid acid (LasGlu and LasX), the keto group is only slightly involved in the formation of the complex.…”

Section: Ft-ir Measurementsmentioning

confidence: 63%

“…Even slight structural modifications [ 8 , 9 , 10 , 11 , 12 , 13 ] of the antibiotic molecules may result in changes to the structure of the complex, which affects the ability of the ionophore to bind metal ions and transport them through the cell lipid layers. For biologically active compounds, such changes may have an impact on their antimicrobial properties [ 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

New Hydrophilic Derivatives of Lasalocid and Their Complexes with Selected Metal Cations

Papsdorf

Pankiewicz

2023

Molecules

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Two new esters of lasalocid, that are more hydrophilic, with glucose (LasGlu) and xylitol (LasX), have been synthesized, and their complexation of monovalent cations has been studied by various spectrometric and spectroscopic methods, such as ESI mass spectrometry, 1H, 13C NMR and FT-IR. Analyses of the results confirmed the synthesis of new esters with good yields. In order to carry out further studies, it was necessary to purify them using “flash“ liquid chromatography. It was confirmed that the newly obtained molecules, as well as their complexes with lithium, sodium and potassium cations, were stabilized by a strong system of intramolecular hydrogen bonds. It was found that the hydroxyl groups of esters derived from xylitol and glucose were also involved in the complexation of cations. The results of the PM6 semiempirical calculations permitted determination of the heat of formation (HOF), and visualization of the structure of the new esters and their complexes with the cations studied. All computation results are in agreement with the spectroscopic data.

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“…Despite the many desirable properties, characterized by high toxicity. Receiving lasalocid acid derivatives, can lead to a reduction of its harmfulness, and thus increase its use 2001;2007;. (Berger et al, 1951).…”

Section: Introductionmentioning

confidence: 99%

SYNTHESIS LASALOCID ESTER WITH PENTADECAFLUORO-1- OCTANOL (LasF AND SEMIEMPIRICAL INVESTIGATION OF ITS COMPLEXES WITH MONOVALENT CATIONS

Tukibayeva¹,

Pankiewicz²,

Kabylbekova³

et al. 2023

SCT

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doctor of chemistry, professor, academician of NAS RK, president of NAS RK, general director of JSC "Institute of fuel, catalysis and electrochemistry named after D.V. Sokolsky (Almaty, Kazakhstan) H = 4 Editorial board: ADEKENOV Sergazy Mynzhasarovich (deputy editor-in-chief) doctor of chemical sciences, professor, academician of NAS RK, director of the international Scientific and production holding «Phytochemistry» (Karaganda, Kazakhstan) H = 11 AGABEKOV Vladimir Enokovich (deputy editor-in-chief), doctor of chemistry, professor, academician of NAS of Belarus, honorary director of the Institute of Chemistry of new materials (Minsk, Belarus) H = 13 STRNAD Miroslav, head of the laboratory of the institute of Experimental Botany of the Czech academy of sciences, professor (Olomouc, Czech Republic) H = 66 BURKITBAYEV Mukhambetkali, doctor of chemistry, professor, academician of NAS RK, first vice-rector of al-Farabi KazNU (Almaty, Kazakhstan) H = 11 HOHMANN Judith, head of the department of pharmacognosy, faculty of Pharmacy, university of Szeged, director of the interdisciplinary center for Life sciences (Szeged, ungary) H = 38 ROSS Samir, Ph.D, professor, school of Pharmacy, national center for scientific research of Herbal Products, University of Mississippi (Oxford, USA) H = 35 KHUTORYANSKY Vitaly, Ph.D, pharmacist, professor at the University of Reading (Reading, England) H = 40 TELTAYEV Bagdat Burkhanbayuly, doctor of technical sciences, professor, corresponding member of NAS RK, ministry of Industry and infrastructure development of the Republic of Kazakhstan (Almaty, Kazakhstan) H = 13 PHARUK Asana Dar, professor at Hamdard al-Majid college of Oriental medicine. faculty of Oriental medicine, Hamdard university (Karachi, Pakistan) H = 21 FAZYLOV Serik Drakhmetovich, doctor of chemistry, professor, academician of NAS RK, deputy director for institute of Organic synthesis and coal chemistry (Karaganda, Kazakhstan) H = 6 ZHOROBEKOVA Sharipa Zhorobekovna, doctor of chemistry, professor, academician of NAS of Kyrgyzstan, Institute of Chemistry and chemical technology of NAS KR (Bishkek, Kyrgyzstan) H = 4 KHALIKOV Jurabay Khalikovich, doctor of chemistry, professor, academician of the academy of sciences of tajikistan, institute of Chemistry named after V.I. Nikitin AS RT (Tajikistan) H = 6 FARZALIEV Vagif Medzhid ogly, doctor of chemistry, professor, academician of NAS of Azerbaijan (Azerbaijan) H = 13 GARELIK Hemda, PhD in chemistry, president of the department of Chemistry and Environment of the International Union of Pure and Applied Chemistry (London, England) H = 15 News of the National Academy of Sciences of the Republic of Kazakhstan. Series of chemistry and technology.

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⁷Li‐NMR and FTIR studies of lithium, potassium, rubidium, and cesium complexes with ionophore lasalocid in solution

Cited by 12 publications

References 41 publications

Multinuclear NMR and FTIR studies of new polyoxaalkyl esters of lasalocid and their complexes with lithium and sodium cations

Multinuclear NMR and FTIR studies of new polyoxaalkyl esters of lasalocid and their complexes with lithium and sodium cations

New Hydrophilic Derivatives of Lasalocid and Their Complexes with Selected Metal Cations

SYNTHESIS LASALOCID ESTER WITH PENTADECAFLUORO-1- OCTANOL (LasF AND SEMIEMPIRICAL INVESTIGATION OF ITS COMPLEXES WITH MONOVALENT CATIONS

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7Li‐NMR and FTIR studies of lithium, potassium, rubidium, and cesium complexes with ionophore lasalocid in solution

Cited by 12 publications

References 41 publications

Multinuclear NMR and FTIR studies of new polyoxaalkyl esters of lasalocid and their complexes with lithium and sodium cations

Multinuclear NMR and FTIR studies of new polyoxaalkyl esters of lasalocid and their complexes with lithium and sodium cations

New Hydrophilic Derivatives of Lasalocid and Their Complexes with Selected Metal Cations

SYNTHESIS LASALOCID ESTER WITH PENTADECAFLUORO-1- OCTANOL (LasF AND SEMIEMPIRICAL INVESTIGATION OF ITS COMPLEXES WITH MONOVALENT CATIONS

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⁷Li‐NMR and FTIR studies of lithium, potassium, rubidium, and cesium complexes with ionophore lasalocid in solution