99Tcm-MDP and 99Tcm-DPD in Pathologic Bone Lesions

Lantto, Tuomo; Vorne, M; Mokka, R; Vähätalo, S

doi:10.1177/028418518702800525

Cited by 9 publications

(8 citation statements)

References 5 publications

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“…If anatomical imaging should be added, hybrid SPECT/CT scanners are available. For detecting bony infections, technetium-99m methylene diphosphonate (99Tcm-MDP) or technetium-99 m-DPD (99Tcm-DPD) are frequently used nuclides; they show no significant differences in detecting “pathologically increased bone uptake” [ 47 ]. MRONJ should not show an uptake in the necrotic zone, but due to the associated infection, a nuclide uptake may be seen.…”

Section: Functional Imagingmentioning

confidence: 99%

Imaging in Patients with Bisphosphonate-Associated Osteonecrosis of the Jaws (MRONJ)

et al. 2016

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Background: Bisphosphonate-associated osteonecrosis of the jaws (MRONJ/BP-ONJ/BRONJ) is a commonly seen disease. During recent decades, major advances in diagnostics have occurred. Once the clinical picture shows typical MRONJ features, imaging is necessary to determine the size of the lesion. Exposed bone is not always painful, therefore a thorough clinical examination and radiological imaging are essential when MRONJ is suspected. Methods: In this paper we will present the latest clinical update on the imaging options in regard to MRONJ: X-ray/Panoramic Radiograph, Cone Beam Computed Tomography (CBCT) and Computed Tomography (CT), Magnetic Resonance Imaging (MRI), Nuclear Imaging, Fluorescence-Guided Bone Resection. Conclusion: Which image modality is chosen depends not only on the surgeon’s/practitioner’s preference but also on the available imaging modalities. A three-dimensional imaging modality is desirable, and in severe cases necessary, for extended resections and planning of reconstruction.

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Section: Functional Imagingmentioning

confidence: 99%

Imaging in Patients with Bisphosphonate-Associated Osteonecrosis of the Jaws (MRONJ)

et al. 2016

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“…All five sites used standard dose or weight-based injected dose adaptation, according to their clinical practice. The targeted post-administration imaging time was 3 h. Since there is no known clinical difference between the two radiopharmaceuticals, we pooled the data (Lantto et al 1987 ).…”

Section: Methodsmentioning

confidence: 99%

“…Bone imaging with 99m Tc 2,3-dicarboxypropane-1,1-diphosphonate (DPD) or methylene diphosphonate (MDP) is one of the main pillars of nuclear medicine for oncology and orthopedic applications (Buell et al 1982 ; Lantto et al 1987 ). Single-photon emission computed tomography (SPECT) with these tracers has superior clinical performance to two-dimensional (2D) scintigraphy (Even-Sapir et al 2009 ).…”

Section: Introductionmentioning

confidence: 99%

ROC study and SUV threshold using quantitative multi-modal SPECT for bone imaging

Vija

Bartenstein

Kuwert

et al. 2019

European J Hybrid Imaging

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Background: We investigated the clinical performance of a quantitative multi-modal SPECT/CT reconstruction platform for yielding radioactivity concentrations of bone imaging with 99m Tc-methylene diphosphonate (MDP) or 99m Tc-dicarboxypropane diphosphonate (DPD). The novel reconstruction incorporates CT-derived tissue information while preserving the delineation of tissue boundaries. We assessed imagebased reader concordance and confidence, and determined lesion classification and SUV thresholds from ROC analysis. Methods: Seventy-two cancer patients were scanned at three US and two German clinical sites, each contributing two experienced board-certified nuclear medicine physicians as readers. We compared four variants of the reconstructed data resulting from the Flash3D (F3D) and the xSPECT Bone™ (xB) iterative reconstruction methods and presented images to the readers with and without a fused CT, resulting in four combinations. We used an all-or-none approach for inclusion, compiling results only when a reader completed all reads in a subset. After the final read, we conducted a "surrogate truth" reading, presenting all data to each reader. For any remaining discordant lesions, we conducted a consensus read. We next undertook ROC analysis to determine SUV thresholds for differentiating benign and lesional uptake.

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“…As technetium is a gamma-radiation emitting radioactive source, the distribution of the tracer can be imaged three-dimensionally using single-photon emission computed tomography (SPECT). Downsides of this method are that it only allows low-resolution imaging and it has a lower sensitivity than other nuclear medicine methods [ 19 ]. Besides 99m Technetium, fluorine-18 ( 18 F) is one of the most common tracers used to target hydroxyapatite in modern nuclear medicine.…”

Section: Introductionmentioning

confidence: 99%

18F- based Quantification of the Osteogenic Potential of hMSCs

Großner

Haberkorn

Gotterbarm

2020

IJMS

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In bone tissue engineering, there is a constant need to design new methods for promoting in vitro osteogenic differentiation. Consequently, there is a strong demand for fast, effective and reliable methods to track and quantify osteogenesis in vitro. In this study, we used the radiopharmacon fluorine-18 (18F) to evaluate the amount of hydroxylapatite produced by mesenchymal stem cells (MSCs) in a monolayer cell culture in vitro. The hydroxylapatite bound tracer was evaluated using µ-positron emission tomography (µ-PET) scanning and activimeter analysis. It was therefore possible to determine the amount of synthesized mineral and thus to conclude the osteogenic potential of the cells. A Student’s t-test revealed a highly significant difference regarding tracer uptake between the osteogenic group and the corresponding control group (µ-PET p = 0.043; activimeter analysis p = 0.012). This tracer uptake showed a highly significant correlation with the gold standard of quantitative Alizarin Red staining (ARS) (r2 = 0.86) as well as with the absolute calcium content detected by inductively coupled plasma mass spectrometry (r2 = 0.81). The results showed that 18F labeling is a novel method to prove and quantify hydroxyapatite content in MSC monolayer cultures. The mineral layer remains intact for further analysis. This non-destructive in vitro method can be used to rapidly investigate bone tissue engineering strategies in terms of hydroxylapatite production, and could therefore accelerate the process of implementing new strategies in clinical practice.

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⁹⁹Tc^m-MDP and ⁹⁹Tc^m-DPD in Pathologic Bone Lesions

Cited by 9 publications

References 5 publications

Imaging in Patients with Bisphosphonate-Associated Osteonecrosis of the Jaws (MRONJ)

Imaging in Patients with Bisphosphonate-Associated Osteonecrosis of the Jaws (MRONJ)

ROC study and SUV threshold using quantitative multi-modal SPECT for bone imaging

18F- based Quantification of the Osteogenic Potential of hMSCs

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