<sup>99m</sup>Tc‐labeled oligomeric nanoparticles as potential agents for folate receptor‐positive tumor targeting

Liang, Lili; Zhang, Xueqian; Su, Xiaoyu; Li, Jianchun; Tian, Yong; Xue, Hongbao; Xu, Huiqin

doi:10.1002/jlcr.3577

Cited by 12 publications

(7 citation statements)

References 23 publications

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“…No positive signal was detected in L02 cells ( Figure S2A). In contrast, FR was strongly expressed in the membrane and cytoplasm of HepG2 cells ( Figure S2B), 27,28 indicating the overexpression of FR in HepG2 cells. To test the in vitro imaging capability of the FA-NPMOFs, HepG2 cells were incubated with FA-NPMOFs at different concentrations.…”

Section: Fa-npmofs Show Bright In Vitro Fluorescence and Low Cytotoximentioning

confidence: 97%

Folic acid-nanoscale gadolinium-porphyrin metal-organic frameworks: fluorescence and magnetic resonance dual-modality imaging and photodynamic therapy in hepatocellular carcinoma

Chen¹,

Liu²,

Shang³

et al. 2018

IJN

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BackgroundHepatocellular carcinoma (HCC) is the most common primary liver cancer and severely threatens human health. Since the prognosis of advanced HCC remains poor, there is an urgent need to develop new therapeutic approaches. Porphyrin metal-organic frameworks are a class of porous organic-inorganic hybrid functional materials with good biocompatibility.MethodsGadolinium-porphyrin metal-organic frameworks were used as a skeleton for folic acid (FA) conjugation to synthesize a novel type of nanoparticle, denoted as folic acid-nanoscale gadolinium-porphyrin metal-organic frameworks (FA-NPMOFs). The FA-NPMOFs were characterized using transmission electron microscopy, Fourier transform infrared spectroscopy and thermogravimetric-differential thermal analysis. The biotoxicity and imaging capability of the FA-NPMOFs were determined using HepG2 cells and embryonic and larval zebrafish. The delivery and photodynamic therapeutic effect of FA-NPMOFs were explored in transgenic zebrafish with doxycycline-induced HCC.ResultsFA-NPMOFs were spherical in structure with good dispersion and water solubility. They showed low biotoxicity, emitted bright red fluorescence, and exhibited an excellent magnetic resonance imaging capability, both in vitro and in vivo. Meanwhile, the FA-NPMOFs exhibited a strong affinity for folate receptor (FR)-expressing cells and were delivered to the tumor site in a targeted manner. Moreover, HCC tumor cells were eliminated following laser irradiation.ConclusionFA-NPMOFs can be used for dual-modality imaging and photodynamic therapy in HCC and show promise for use as a carrier in new therapies for HCC and other FR-positive tumors.

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Section: Fa-npmofs Show Bright In Vitro Fluorescence and Low Cytotoximentioning

confidence: 97%

Folic acid-nanoscale gadolinium-porphyrin metal-organic frameworks: fluorescence and magnetic resonance dual-modality imaging and photodynamic therapy in hepatocellular carcinoma

Chen¹,

Liu²,

Shang³

et al. 2018

IJN

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“…These “charged” NPs, when in contact with radioactive ions (with an opposite charge from the NP), can immobilize on the stationary layer between the particle surface and the dispersed medium. In this type of reaction, no discrete covalent or dative covalent bond is observed (Oda et al., 2017 ; Shi et al., 2017 ; Liang et al., 2018 ). Thirdly, direct chemisorption of polymeric NPs is direct and chemically bonded with the radionuclide.…”

Section: Radioactive Polymeric Nanoparticles For Imaging and Therapymentioning

confidence: 99%

“…Liang and colleagues prepared an oligomeric NP conjugated with a folic acid receptor and radiolabeled with 99m Tc. These NPs presented selectivity for folate receptor in tumor cells and due to their selectivity, can be an option for SPECT/CT imaging (Liang et al., 2018 ).…”

Section: Radioactive Polymeric Nanoparticles For Biomedical Applicatimentioning

confidence: 99%

Radioactive polymeric nanoparticles for biomedical application

Wu¹,

Helal-Neto

Matos

et al. 2020

Drug Delivery

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Nowadays, emerging radiolabeled nanosystems are revolutionizing medicine in terms of diagnostics, treatment, and theranostics. These radionuclides include polymeric nanoparticles (NPs), liposomal carriers, dendrimers, magnetic iron oxide NPs, silica NPs, carbon nanotubes, and inorganic metal-based nanoformulations. Between these nano-platforms, polymeric NPs have gained attention in the biomedical field due to their excellent properties, such as their surface to mass ratio, quantum properties, biodegradability, low toxicity, and ability to absorb and carry other molecules. In addition, NPs are capable of carrying high payloads of radionuclides which can be used for diagnostic, treatment, and theranostics depending on the radioactive material linked. The radiolabeling process of nanoparticles can be performed by direct or indirect labeling process. In both cases, the most appropriate must be selected in order to keep the targeting properties as preserved as possible. In addition, radionuclide therapy has the advantage of delivering a highly concentrated absorbed dose to the targeted tissue while sparing the surrounding healthy tissues. Said another way, radioactive polymeric NPs represent a promising prospect in the treatment and diagnostics of cardiovascular diseases such as cardiac ischemia, infectious diseases such as tuberculosis, and other type of cancer cells or tumors.

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“…A direct methodology based on double emulsion technique for radiolabelling 68 Ga with polymeric nanoparticle of various size range has shown greater than 90% labelling efficacy and appreciable plasma stability 141 . The 99m Tc 99m Tc‐labelled oligomeric nanoparticles can also be tagged with folic acid targeting moieties to increase tumour targeting 142 …”

Section: Different Nanoparticle Systems Used For Delivery Of Radiophamentioning

confidence: 99%

Nanoparticulate formulations of radiopharmaceuticals: Strategy to improve targeting and biodistribution properties

Datta

Ray

2020

Labelled Comp Radiopharmac

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Application of nanotechnology principles in drug delivery has created opportunities for treatment of several diseases. Nanotechnology offers the advantage of overcoming the adverse biopharmaceutics or pharmacokinetic properties of drug molecules, to be determined by the transport properties of the particles themselves. Through the manipulation of size, shape, charge, and type of nanoparticle delivery system, variety of distribution profiles may be obtained. However, there still exists greater need to derive and standardize definitive structure property relationships for the distribution profiles of the delivery system. When applied to radiopharmaceuticals, the delivery systems assume greater significance. For the safety and efficacy of both diagnostics and therapeutic radiopharmaceuticals, selective localization in target tissue is even more important. At the same time, the synthesis and fabrication reactions of radiolabelled nanoparticles need to be completed in much shorter time. Moreover, the extensive understanding of the several interesting optical and magnetic properties of materials in nanoscale provides for achieving multiple objectives in nuclear medicine. This review discusses the various nanoparticle systems, which are applied for radionuclides and analyses the important bottlenecks that are required to be overcome for their more widespread clinical adaptation.

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^99mTc‐labeled oligomeric nanoparticles as potential agents for folate receptor‐positive tumor targeting

Cited by 12 publications

References 23 publications

Folic acid-nanoscale gadolinium-porphyrin metal-organic frameworks: fluorescence and magnetic resonance dual-modality imaging and photodynamic therapy in hepatocellular carcinoma

Folic acid-nanoscale gadolinium-porphyrin metal-organic frameworks: fluorescence and magnetic resonance dual-modality imaging and photodynamic therapy in hepatocellular carcinoma

Radioactive polymeric nanoparticles for biomedical application

Nanoparticulate formulations of radiopharmaceuticals: Strategy to improve targeting and biodistribution properties

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