2017
DOI: 10.1089/ten.tec.2017.0164
|View full text |Cite
|
Sign up to set email alerts
|

In VivoModels for the Evaluation of the Osteogenic Potency of Bone Substitutes Seeded with Mesenchymal Stem Cells of Human Origin: A Concise Review

Abstract: Research concerning bone substitutes is one of the most challenging fields in orthopedic research and has a high clinical relevance, especially since the currently available bone substitutes are limited in their osteostimulative capabilities. In vitro models for the evaluation of the properties of bone substitutes allow the use of human mesenchymal stem cells (hMSCs) seeded onto scaffolds, but suffer from the lack of a physiological environment for those cells. Most in vivo models include the use of non-hMSC a… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
2

Citation Types

0
26
1

Year Published

2018
2018
2024
2024

Publication Types

Select...
3
2

Relationship

0
5

Authors

Journals

citations
Cited by 21 publications
(27 citation statements)
references
References 59 publications
0
26
1
Order By: Relevance
“…To prove our method, we used data acquired by a well‐established model for in vivo analysis of bone substitutes . By addition of BMP‐7 to ß‐TCP‐scaffolds, bone formation within the scaffold can be enhanced as demonstrated previously .…”
Section: Discussionmentioning
confidence: 99%
See 2 more Smart Citations
“…To prove our method, we used data acquired by a well‐established model for in vivo analysis of bone substitutes . By addition of BMP‐7 to ß‐TCP‐scaffolds, bone formation within the scaffold can be enhanced as demonstrated previously .…”
Section: Discussionmentioning
confidence: 99%
“…In this case, relative bone volume was nonsignificantly smaller than the percentage bone amount in 2D mCT evaluation and histomorphometry. This may be caused by the selection of “optimal” locations of a scaffold in cutting for histomorphometry preparation, as well as the assumption that due to the mechanical conditions of the in vivo model we used, bone formation most likely takes place in the porous center of the scaffold and not on the boundaries, which are less influenced by mechanical stress …”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Synthetic bone substitutes are frequently used for several applications in orthopaedic surgery (Giannoudis, Dinopoulos, & Tsiridis, ). The most common bone scaffold materials are calcium phosphate ceramics, such as tricalcium phosphates or hydroxyapatites (Janicki & Schmidmaier, ; Westhauser, Senger, Reible, & Moghaddam, ). However, these materials show some limitations regarding biological properties, such as limited stimulation of bone formation within the scaffold structure, that are mostly linked to morphological characteristics such as porosity or surface area (Cao & Hench, ; Janicki & Schmidmaier, ).…”
Section: Introductionmentioning
confidence: 99%
“…In addition, the effect of gelatin surface coating on both osteogenic properties and mechanical features has not been investigated previously. In this study, uncoated (Group A) and gelatin‐coated (Group B) 3D BG‐based scaffolds obtained from S. agaricina as a template, seeded with human bone marrow‐derived MSCs (hBMSC), are evaluated concerning osteogenic properties using an established in vivo model (Westhauser, Senger, et al, ). Bone formation is quantified by non‐invasive micro‐computed tomography (mCT) evaluation and assessed both quantitatively and qualitatively by histomorphometry (Westhauser, Senger, et al, ; Westhauser, Weis, et al, ).…”
Section: Introductionmentioning
confidence: 99%