Super Hydrophilic Thin Film Nitinol Demonstrates Reduced Platelet Adhesion Compared with Commercially Available Endograft Materials

Tulloch, Allan W.; Chun, Youngjae; Levi, Daniel S.; Mohanchandra, K. P.; Carman, Gregory P.; Lawrence, Peter F.; Rigberg, David A.

doi:10.1016/j.jss.2010.01.014

Cited by 28 publications

(21 citation statements)

References 23 publications

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“…40,41 The wettability measurements in the present study show that the surface free energy of the materials and their hydrophilicity/hydrophobicity dictate platelet response. The CNT/ DLC and TiBN thin films were found to be hydrophobic, whereas the CAs of the a-C:H and TiB 2 samples indicated their hydrophilic nature.…”

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confidence: 66%

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Novel nanostructured biomaterials: implications for coronary stent thrombosis

Karagkiozaki¹,

Karagiannidis²,

Kalfagiannis³

et al. 2012

IJN

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Background: Nanomedicine has the potential to revolutionize medicine and help clinicians to treat cardiovascular disease through the improvement of stents. Advanced nanomaterials and tools for monitoring cell-material interactions will aid in inhibiting stent thrombosis. Although titanium boron nitride (TiBN), titanium diboride, and carbon nanotube (CNT) thin films are emerging materials in the biomaterial field, the effect of their surface properties on platelet adhesion is relatively unexplored. Objective and methods: In this study, novel nanomaterials made of amorphous carbon, CNTs, titanium diboride, and TiBN were grown by vacuum deposition techniques to assess their role as potential stent coatings. Platelet response towards the nanostructured surfaces of the samples was analyzed in line with their physicochemical properties. As the stent skeleton is formed mainly of stainless steel, this material was used as reference material. Platelet adhesion studies were carried out by atomic force microscopy and scanning electron microscopy observations. A cell viability study was performed to assess the cytocompatibility of all thin film groups for 24 hours with a standard immortalized cell line. Results: The nanotopographic features of material surface, stoichiometry, and wetting properties were found to be significant factors in dictating platelet behavior and cell viability. The TiBN films with higher nitrogen contents were less thrombogenic compared with the biased carbon films and control. The carbon hybridization in carbon films and hydrophilicity, which were strongly dependent on the deposition process and its parameters, affected the thrombogenicity potential. The hydrophobic CNT materials with high nanoroughness exhibited less hemocompatibility in comparison with the other classes of materials. All the thin film groups exhibited good cytocompatibility, with the surface roughness and surface free energy influencing the viability of cells.

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confidence: 66%

“…These two properties have been postulated to decrease the attachment of platelets. 41 Overall, the surface chemistry, nanotopographical features, and wetting properties of the examined materials influence the variability of platelet response when they come into contact.…”

mentioning

confidence: 99%

Novel nanostructured biomaterials: implications for coronary stent thrombosis

Karagkiozaki¹,

Karagiannidis²,

Kalfagiannis³

et al. 2012

IJN

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“…[11][12][13] Recently, our group has developed a hyperelastic TFN (HE-TFN) metal mesh that is capable of undergoing mechanical deformations greater than 400% without failure.…”

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confidence: 99%

In vitro and in vivo testing of a novel, hyperelastic thin film nitinol flow diversion stent

et al. 2011

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A flexible, low profile, flow diversion stent could replace endovascular coiling for the treatment of intracranial aneurysms. Micropatterned-thin film nitinol (TFN) is a novel biomaterial with high potential for use in next-generation endovascular devices. Recent advancements in micropatterning have allowed for fabrication of a hyperelastic thin film nitinol (HE-TFN). In this study, the authors describe in vitro and in vivo testing of novel HE-TFN based flow diverting stents. Two types of HE-TFN with expanded pores having long axes of 300 and 500 μm were used to fabricate devices. In vitro examination of the early thrombotic response in whole blood showed a possible mechanism for the device's function, whereby HE-TFN serves as a scaffold for blood product deposition. In vivo testing in swine demonstrated rapid occlusion of model wide-neck aneurysms. Average time to occlusion for the 300-μm device was 10.4 ± 5.5 min. (N = 5) and 68 ± 30 min for the 500-μm device (N = 5). All aneurysms treated with bare metal control stents remained patent after 240 min (N = 3). SEM of acutely harvested devices supported in vitro results, demonstrating that HE-TFN serves as a scaffold for blood product deposition, potentially enhancing its flow-diverting effect. Histopathology of devices after 42 days in vivo demonstrated a healthy neointima and endothelialization of the aneurysm neck region. HE-TFN flow-diverting stents warrant further investigation as a novel treatment for intracranial aneurysms.

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“…Another unique feature of 65 nitinol is the superelasticity that provides high resistance against 66 plastic deformation during the device delivery in tortuous vascula-67 ture (i.e., kink resistance) and in the device placed in the artery or 68 vein where cyclic hemodynamic loads occur (i.e., fatigue resis- 69 tance). When mechanical loading is applied to superelastic nitinol 70 (i.e., austenite phase), a reversible and elastic deformation with 71 high strains is observed due to the stress-induced phase trans- 72 formation or twinning. At the temperature above austenite trans- 73 formation temperature, the phase transformation from austenite 74 to martensite occurs under mechanical loading and the material 75 can reversibly deform in a high strain (e.g.…”

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confidence: 99%

“…Fig. 6 shows that both untreated and treated thin film 570 nitinol appear to attract significantly less thrombus than ePTFE 571 [70,71]. 572 In addition to in vitro hemocompatibility tests, in vivo swine test 573 was performed on superhydrophilic thin film nitinol to evaluate 574 both thrombogenicity and neointimal growth.…”

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confidence: 99%