“…As a logical consequence, photoactivated localization microscopy (PALM) (Betzig et al, 2006;Shroff et al, 2007;Shroff et al, 2008), fluorescence photoactivation localization microscopy (FPALM) Hess et al, 2007) and stochastic optical reconstruction microscopy (STORM) using special pairs of fluorophores (Rust et al, 2006;Bates et al, 2007) were introduced shortly afterwards. A short time later, the use of commercially available organic fluorescent probes, such as fluorophore-labeled antibodies or phalloidin probes, was demonstrated for super-resolution imaging by direct STORM (dSTORM), facilitating the acceptance and broad applicability of localization microscopy Heilemann et al, 2009;van de Linde et al, 2011a;Jones et al, 2011;Dempsey et al, 2011;Sillibourne et al, 2011;Williamson et al, 2011;Kaminski-Schierle et al, 2011;van de Linde et al, 2012;Zessin et al, 2012;Lampe et al, 2012;Wilmes et al, 2012;Rossy et al, 2013;Mattila et al, 2013). Furthermore, other localization microscopy methods using photoswitching of standard organic fluorophores under slightly different experimental conditions emerged under the names of GSDIM (ground-state depletion microscopy followed by individual molecule return) (Fölling et al, 2008) and blink microscopy .…”