Super-Resolution Imaging and Microscopy by Dielectric Particle-Lenses

Wang, Zengbo; Luk’yanchuk, Boris

doi:10.1007/978-3-030-21722-8_15

Cited by 22 publications

(31 citation statements)

References 109 publications

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“…For super-resolution imaging, both BTG and meta-TiO 2 microsphere are immersed in a transparent host material to create a proper super-resolution imaging condition, which generates magnified virtual images of underlying nano-objects [21,27,28]. In this study, the PDMS host was used.…”

Section: Methodsmentioning

confidence: 99%

“…New microspheres, including Polystyrene and BaTiO 3 glass (BTG) microspheres (immersed in liquid or solid encapsulated), were soon introduced and widely used in the field [16,17]. The field has undergone rapid developments, including the development of scanning superlens, higher resolution metamaterial superlens [18,19], biological superlens [20], and integrated biochips, as well as new applications in interferometry, endoscopy, and others [21]. The underlying super-resolution mechanism is pretty complex and is still under investigation, which seems to be a mixing of photonic nanojet, optical super-resonances [22,23], illumination condition, and substrate effect, which were all summarized in our recent reviews [21,24,25].…”

Section: Introductionmentioning

confidence: 99%

“…The field has undergone rapid developments, including the development of scanning superlens, higher resolution metamaterial superlens [18,19], biological superlens [20], and integrated biochips, as well as new applications in interferometry, endoscopy, and others [21]. The underlying super-resolution mechanism is pretty complex and is still under investigation, which seems to be a mixing of photonic nanojet, optical super-resonances [22,23], illumination condition, and substrate effect, which were all summarized in our recent reviews [21,24,25]. Among these, it remains unclear which superlens will perform better, BTG or metamaterial superlens, which is a hemispherical all-dielectric lens made by 3D stacking of 15-20 nm titanium dioxide (TiO 2 ) nanoparticles (n = 2.50-2.55) following a bottom-up synthesis approach, with super-resolution of at least 45 nm have been reported under a white light microscope [18].…”

Section: Introductionmentioning

confidence: 99%

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Super-Resolution Imaging by Dielectric Superlenses: TiO2 Metamaterial Superlens versus BaTiO3 Superlens

et al. 2021

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All-dielectric superlens made from micro and nano particles has emerged as a simple yet effective solution to label-free, super-resolution imaging. High-index BaTiO3 Glass (BTG) microspheres are among the most widely used dielectric superlenses today but could potentially be replaced by a new class of TiO2 metamaterial (meta-TiO2) superlens made of TiO2 nanoparticles. In this work, we designed and fabricated TiO2 metamaterial superlens in full-sphere shape for the first time, which resembles BTG microsphere in terms of the physical shape, size, and effective refractive index. Super-resolution imaging performances were compared using the same sample, lighting, and imaging settings. The results show that TiO2 meta-superlens performs consistently better over BTG superlens in terms of imaging contrast, clarity, field of view, and resolution, which was further supported by theoretical simulation. This opens new possibilities in developing more powerful, robust, and reliable super-resolution lens and imaging systems.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Super-Resolution Imaging by Dielectric Superlenses: TiO2 Metamaterial Superlens versus BaTiO3 Superlens

et al. 2021

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“…For instance, incorporation of high-index microsphere into flexible elastomers was reported to improve its durability and reusability for observations at a specific position [16,17]. Microsphere was coupled with a confocal microscope to improve the maximal resolvability to sub-50nm scale [18,19,20]. Furthermore, micro-lens nanoscopes in extraordinary forms were also demonstrated, such as nanoparticle-based metamaterial hemisphere superlens leading to white-lighting 45 nm resolution [21], and biological superlens using spider silks and cells [22,23].…”

Section: Introductionmentioning

confidence: 99%

Unibody microscope objective tipped with a microsphere: design, fabrication, and application in subwavelength imaging

et al. 2020

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Microsphere-based subwavelength imaging technique was first demonstrated in 2011. After nearly a decade of efforts, such technique has spawned numerous interests in fields such as laser nano-machining, imaging, sensing and biological detection. For wider industrial scale application of the technique, a robust, low-cost objective lens incorporating microsphere lens is highly desired and sought by many researchers. In this work, we demonstrate a unibody microscope objective lens formed by tipping a high-index microsphere onto a Plano-Convex lens and subsequently fitting them into a conventional objective lens. We call such new objective the Plano-Convex-Microsphere (PCM) objective, which resembles the appearance and operation of an ordinary microscope objective, while providing super-resolving power in discerning subwavelength nanoscale features in air condition. The imaging performance of PCM-objective along with the working distance has been systematically investigated. With the assistance of scanning process, larger area imaging is realized. The PCM-objective can be easily adaptive to many existing microscope systems and appealing for commercialization.

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“…This label-free super-resolution imaging technique has attracted many research groups across the world, demonstrating sub-diffraction discerning ability in nanostructure detections and biological observations [10][11][12][13]. The super-resolution mechanism of microsphere-assisted microscopy is still a heated topic [14][15][16]. Early in 2004, the dielectric microsphere was regarded as a potential new visible-light super-resolution technique through a phenomenon known as "photonic nanojet" (PNJ), which has a narrow waist and an extraordinarily high optical intensity formed on the shadow-side surface of a plane-wave-illuminated dielectric microsphere [17].…”

Section: Introductionmentioning

confidence: 99%

Coated High-Refractive-Index Barium Titanate Glass Microspheres for Optically Trapped Microsphere Super-Resolution Microscopy: A Simulation Study

Liu

Tang

2020

Photonics

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As water is normally used as the immersion medium in optically trapped microsphere microscopy, the high-refractive-index barium titanate glass (BTG) microsphere shows a better imaging performance than the low-index polystyrene (PS) or melamine formaldehyde (MF) microsphere, but it is difficult to be trapped by single-beam optical trapping due to its overly high refractive index. In this study, coated BTG microspheres with a PS coating have been computationally explored for the combination of optical trapping with microsphere-assisted microscopy. The PS coating thickness affects both the optical trapping efficiency and photonic nanojet (PNJ) property of the coated BTG sphere. Compared to the uncoated BTG sphere, the coated BTG sphere with a proper PS coating thickness has a highly improved trapping efficiency which enables single-beam optical trapping, and a better PNJ with a higher optical intensity and a narrower full width at half maximum (FWHM) corresponding to better imaging performance. These coated BTG spheres also have an advantage in trapping efficiency and imaging performance over conventional PS and MF spheres. The coated BTG microsphere is highly desirable for optically trapped microsphere super-resolution microscopy and potentially beneficial to other research areas, such as nanoparticle detection.

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Super-Resolution Imaging and Microscopy by Dielectric Particle-Lenses

Cited by 22 publications

References 109 publications

Super-Resolution Imaging by Dielectric Superlenses: TiO2 Metamaterial Superlens versus BaTiO3 Superlens

Super-Resolution Imaging by Dielectric Superlenses: TiO2 Metamaterial Superlens versus BaTiO3 Superlens

Unibody microscope objective tipped with a microsphere: design, fabrication, and application in subwavelength imaging

Coated High-Refractive-Index Barium Titanate Glass Microspheres for Optically Trapped Microsphere Super-Resolution Microscopy: A Simulation Study

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