Super-resolution track-density imaging studies of mouse brain: Comparison to histology

Calamante, Fernando; Tournier, Jacques‐Donald; Kurniawan, Nyoman D.; Yang, Zhengyi; Gyengési, Erika; Galloway, Graham J.; Reutens, David C.; Connelly, Alan

doi:10.1016/j.neuroimage.2011.07.014

Cited by 107 publications

(124 citation statements)

References 22 publications

(18 reference statements)

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“…DWI data were acquired in accordance with protocols previously described (Calamante et al, 2012b;Moldrich et al, 2010). In brief, data were acquired on a 16.4 Tesla vertical bore animal system (Bruker Biospin, Germany) using a Micro2.5 gradient system and a 15 mm linear surface coil (M2M, Australia).…”

Section: Mri Data Acquisitionmentioning

confidence: 99%

“…Short-track tracking (stTDI), where the track length was constrained to a maximum of 1mm to enhance visualization of certain brain structures by only considering local connectivity (Calamante et al, 2012b). In particular, stTDI was used to visualize the posterior medial barrel sub-field (PMBSF), as previously described (Kurniawan et al, 2014); e.g.…”

Section: Fibre Tracking Mrimentioning

confidence: 99%

“…(ii) Partial-brain fibre tracking for reduced field-of-view stTDI: While the stTDI approach can provide enhanced contrast, it requires the generation of a much larger number of tracks (Calamante et al, 2012b). Furthermore, the larger the number of tracks, the greater the signal-to-noise (SNR) ratio.…”

Section: Fibre Tracking Mrimentioning

confidence: 99%

“…Directionally encoded color TDI maps were also generated, in which the color encodes the local fibre orientation (red: left-right, green: dorsal-ventral, blue: rostral-caudal) (Calamante et al, 2012b).…”

Section: Tdi and Sttdimentioning

confidence: 99%

“…In particular, when combined with ultra-high field MRI, this technique provides very high-resolution images with rich anatomical contrast in the mouse brain (Calamante et al, 2012b).…”

Section: Introductionmentioning

confidence: 99%

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Mapping somatosensory connectivity in adult mice using diffusion MRI tractography and super-resolution track density imaging

et al. 2014

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Section: Mri Data Acquisitionmentioning

confidence: 99%

Section: Fibre Tracking Mrimentioning

confidence: 99%

Section: Fibre Tracking Mrimentioning

confidence: 99%

Section: Tdi and Sttdimentioning

confidence: 99%

“…In particular, when combined with ultra-high field MRI, this technique provides very high-resolution images with rich anatomical contrast in the mouse brain (Calamante et al, 2012b).…”

Section: Introductionmentioning

confidence: 99%

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Mapping somatosensory connectivity in adult mice using diffusion MRI tractography and super-resolution track density imaging

et al. 2014

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Structural brain anomalies in patients with FOXG1 syndrome and in Foxg1+/− mice

Pringsheim

Mitter

Schröder

et al. 2019

Ann Clin Transl Neurol

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Objective FOXG 1 syndrome is a rare neurodevelopmental disorder associated with heterozygous FOXG 1 variants or chromosomal microaberrations in 14q12. The study aimed at assessing the scope of structural cerebral anomalies revealed by neuroimaging to delineate the genotype and neuroimaging phenotype associations. Methods We compiled 34 patients with a heterozygous (likely) pathogenic FOXG 1 variant. Qualitative assessment of cerebral anomalies was performed by standardized re‐analysis of all 34 MRI data sets. Statistical analysis of genetic, clinical and neuroimaging data were performed. We quantified clinical and neuroimaging phenotypes using severity scores. Telencephalic phenotypes of adult Foxg1 +/− mice were examined using immunohistological stainings followed by quantitative evaluation of structural anomalies. Results Characteristic neuroimaging features included corpus callosum anomalies (82%), thickening of the fornix (74%), simplified gyral pattern (56%), enlargement of inner CSF spaces (44%), hypoplasia of basal ganglia (38%), and hypoplasia of frontal lobes (29%). We observed a marked, filiform thinning of the rostrum as recurrent highly typical pattern of corpus callosum anomaly in combination with distinct thickening of the fornix as a characteristic feature. Thickening of the fornices was not reported previously in FOXG 1 syndrome. Simplified gyral pattern occurred significantly more frequently in patients with early truncating variants. Higher clinical severity scores were significantly associated with higher neuroimaging severity scores. Modeling of Foxg1 heterozygosity in mouse brain recapitulated the associated abnormal cerebral morphology phenotypes, including the striking enlargement of the fornix. Interpretation Combination of specific corpus callosum anomalies with simplified gyral pattern and hyperplasia of the fornices is highly characteristic for FOXG 1 syndrome.

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Super-resolution track-density imaging of thalamic substructures: Comparison with high-resolution anatomical magnetic resonance imaging at 7.0T

Calamante¹,

Oh²,

Tournier³

et al. 2012

Hum. Brain Mapp.

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The thalamus is one of the most important brain structures, with strong connections between subcortical and cortical areas of the brain. Most of the incoming information to the cortex passes through the thalamus. Accurate identification of substructures of the thalamus is therefore of great importance for the understanding of human brain connectivity. Direct visualization of thalamic substructures, however, is not easily achieved with currently available magnetic resonance imaging (MRI), including ultra-high field MRI such as 7.0T, mainly due to the limited contrast between the relevant structures. Recently, improvements in ultra-high field 7.0T MRI have opened the possibility of observing thalamic substructures by well-adjusted high-resolution T1 -weighted imaging. Moreover, the recently developed super-resolution track-density imaging (TDI) technique, based on results from whole-brain fiber-tracking, produces images with sub-millimeter resolution. These two methods enable us to show markedly improved anatomical detail of the substructures of the thalamus, including their detailed locations and directionality. In this study, we demonstrate the role of TDI for the visualization of the substructures of the thalamic nuclei, and relate these images to T1-weighted imaging at 7.0T MRI.

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Super-resolution track-density imaging studies of mouse brain: Comparison to histology

Cited by 107 publications

References 22 publications

Mapping somatosensory connectivity in adult mice using diffusion MRI tractography and super-resolution track density imaging

Mapping somatosensory connectivity in adult mice using diffusion MRI tractography and super-resolution track density imaging

Structural brain anomalies in patients with FOXG1 syndrome and in Foxg1+/− mice

Super-resolution track-density imaging of thalamic substructures: Comparison with high-resolution anatomical magnetic resonance imaging at 7.0T

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