2018
DOI: 10.1021/jacs.8b01902
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Superactivity of MOF-808 toward Peptide Bond Hydrolysis

Abstract: MOF-808, a Zr(IV)-based metal-organic framework, has been proven to be a very effective heterogeneous catalyst for the hydrolysis of the peptide bond in a wide range of peptides and in hen egg white lysozyme protein. The kinetic experiments with a series of Gly-X dipeptides with varying nature of amino acid side chain have shown that MOF-808 exhibits selectivity depending on the size and chemical nature of the X side chain. Dipeptides with smaller or hydrophilic residues were hydrolyzed faster than those with … Show more

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Cited by 153 publications
(213 citation statements)
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“…[10] Recently,a Zr IV based MOF-808w as reported to promote selective peptide bond hydrolysis in hen egg-white lysozyme (HEWL). [11] Althought he exact peptide bonds at which hydrolysis occurred have not been examined, this study demonstratedt he first example of ah eterogeneous protein hydrolysis by as table metal-organic framework catalyst.…”
Section: Introductionmentioning
confidence: 84%
“…[10] Recently,a Zr IV based MOF-808w as reported to promote selective peptide bond hydrolysis in hen egg-white lysozyme (HEWL). [11] Althought he exact peptide bonds at which hydrolysis occurred have not been examined, this study demonstratedt he first example of ah eterogeneous protein hydrolysis by as table metal-organic framework catalyst.…”
Section: Introductionmentioning
confidence: 84%
“…Recently, Vogt et al utilized the MOF-808, a Zr(IV)-based metal−organic complex for the hydrolysis of the peptide bond in a wide range of peptides and proteins such as hen egg white lysozyme (HEWL) under physiological conditions [ 81 , 82 ]. The MOF-88 is heterogeneous in nature and is thus a reusable catalyst.…”
Section: Metal Complexes For the Activation Of Amide Bondsmentioning
confidence: 99%
“…However, the performance of amorphous POPs is affected by its irregular pores, burying a large fraction of porosity 9 , and hindering fast mass transfer needed for real-time response 10 . Although MOFs have regular pores and good crystallinity 8 , stability under extreme conditions (acid, base, temperature, and radiation) remains a challenge [11][12][13] . High stability is particularly important for the extraction of UO 2 2+ , as the sample matrix is likely to be strongly radioactive and acidic.…”
mentioning
confidence: 99%