Superchaotropic polyoxometalates as membrane carriers

Kondinski, Aleksandar

doi:10.26599/pom.2024.9140058

Polyoxometalates

2024

DOI: 10.26599/pom.2024.9140058

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Superchaotropic polyoxometalates as membrane carriers

Aleksandar Kondinski

Abstract: In the realm of pharmaceutical drug delivery and bioimaging, the innovative design of membrane transporters is crucial. This highlight article focuses on the recent collaborative study published in Advanced Materials

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2024

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Cited by 8 publications

References 35 publications

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Boron Cluster Anions Dissolve En Masse in Lipids Causing Membrane Expansion and Thinning

Barba‐Bon,

El Haitami,

Pasquier

et al. 2024

Angewandte Chemie

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Boron clusters are applied in medicinal chemistry because of their high stability in biological environments and intrinsic ability to capture neutrons. However, their intermolecular interactions with lipid membranes, which is critical for their cellular delivery and biocompatibility, have not been comprehensively investigated. In this study, we combine different experimental methods – Langmuir monolayer isotherms at the air‐water interface, calorimetry (DSC, ITC), and scattering techniques (DLS, SAXS) – with MD simulations to evaluate the impact of closo‐dodecaborate clusters on model membranes of different lipid composition. The cluster anions interact strongly with zwitterionic membranes (POPC and DPPC) via the chaotropic effect and cause pronounced expansions of lipid monolayers. The resulting lipid membranes contain up to 33 mol% and up to 52 weight% of boron cluster anions even at low aqueous cluster concentrations (1 mM). They show high (μM) affinity to the hydrophilic‐hydrophobic interface, affecting the structuring of the lipid chains, and triggering a sequence of characteristic effects: (i) an expansion of the surface area per lipid, (ii) an increase in membrane fluidity, and (iii) a reduction of bilayer thickness. These results aid the design of boron cluster derivatives as auxiliaries in drug design and transmembrane carriers and help rationalize potential toxicity effects.

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Boron Cluster Anions Dissolve En Masse in Lipids Causing Membrane Expansion and Thinning

Barba‐Bon,

El Haitami,

Pasquier

et al. 2024

Angewandte Chemie

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show abstract

Boron Cluster Anions Dissolve En Masse in Lipids Causing Membrane Expansion and Thinning

Barba‐Bon,

El Haitami,

Pasquier

et al. 2024

Angew Chem Int Ed

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Nitrite Electroreduction Enhanced by Hybrid Compounds of Keggin Polyoxometalates and 1‐Butyl‐3‐Vinylimidazolium

Zhou,

Sun,

Gallet

et al. 2024

ChemCatChem

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We describe here an immobilization method of four Keggin‐type polyoxometalates (POMs) ([H2W12O40]6‐, [BW12O40]5‐ [SiW12O40]4‐, [PW12O40]3‐) by using the reaction with an ionic liquid, 1‐butyl‐3‐vinylimidazolium (BVIM) bromide. The reaction yields a hybrid material (BVIM‐POM) as a water‐insoluble salt. The chemical structure of both compounds is preserved, as indicated by infrared spectroscopy (FT‐IR), although with a reduced crystallinity (shown by X‐ray diffraction analysis) due to a decrease of water content (shown by thermogravimetric analysis). Cross polarization 1H‐31P NMR evidenced the presence of BVIM in the structure of (BVIM)3[PW12O40]. The salt is mixed with carbon powder and Nafion to prepare an ink and casted on glassy carbon electrodes. The electrochemical behavior of immobilized POMs material is preserved. The electrochemical activity for nitrite reduction is measured by cyclic voltammetry and differential electrochemical mass spectrometry (DEMS). It was observed that the reduction current of 10 mM HNO2 at pH 1 in 0.5 M Na2SO4 is enhanced in the presence of these hybrid materials. DEMS has evidenced the formation of nitrous oxide (N2O) at potentials more positive compared to the use of parent POMs in solution.

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Superchaotropic polyoxometalates as membrane carriers

Abstract: In the realm of pharmaceutical drug delivery and bioimaging, the innovative design of membrane transporters is crucial. This highlight article focuses on the recent collaborative study published in Advanced Materials

Cited by 8 publications

References 35 publications

Boron Cluster Anions Dissolve En Masse in Lipids Causing Membrane Expansion and Thinning

Boron Cluster Anions Dissolve En Masse in Lipids Causing Membrane Expansion and Thinning

Boron Cluster Anions Dissolve En Masse in Lipids Causing Membrane Expansion and Thinning

Nitrite Electroreduction Enhanced by Hybrid Compounds of Keggin Polyoxometalates and 1‐Butyl‐3‐Vinylimidazolium

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