2024
DOI: 10.1126/sciadv.adk6331
|View full text |Cite
|
Sign up to set email alerts
|

Supercharged precision killers: Genetically engineered biomimetic drugs of screened metalloantibiotics against Acinetobacter baumanni

Xianyuan Wei,
Bin Xue,
Shuangchen Ruan
et al.

Abstract: To eliminate multidrug-resistant bacteria of Acinetobacter baumannii , we screened 1100 Food and Drug Administration–approved small molecule drugs and accessed the broxyquinoline (Bq) efficacy in combination with various metal ions. Antibacterial tests demonstrated that the prepared Zn(Bq) 2 complex showed ultralow minimum inhibitory concentration of ~0.21 micrograms per milliliter with no resistance after 30 passages. We then constructed the nano zeolitic imidaz… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

0
0
0

Year Published

2024
2024
2024
2024

Publication Types

Select...
2

Relationship

0
2

Authors

Journals

citations
Cited by 2 publications
references
References 64 publications
0
0
0
Order By: Relevance