Supercritical CO2 Generation of Nanometric Structure from Ocimum basilicum Mucilage Prepared for Pharmaceutical Applications

Akbari, Iman; Ghoreishi, S.M.; Habibi, Neda

doi:10.1208/s12249-014-0212-x

Cited by 9 publications

(3 citation statements)

References 24 publications

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“…The procedure of mucilage extraction from basil seeds was described in details in our previous work [15]. As stated in the mentioned study, the basil seeds were completely swelled in distilled water.…”

Section: Mucilage Extraction Proceduresmentioning

confidence: 99%

“…DOI: https://dx.doi.org/10.17352/ijpsdr.000014 nonporous structure for pharmaceutical applications [14]. In the mentioned work, drying procedure was performed using a modifi ed method based on Temtem et al [15] study in which methanol was used as co-solvent to improve water solubility in SC-CO2. In the other previous work, ocimum basilicum mucilage was employed as a cost effective polymeric medium for precipitation of paclitaxel for controlled drug delivery [14].…”

Section: Introductionmentioning

confidence: 99%

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Generation of Porous Structure from Basil Seed Mucilage via Supercritical Fluid Assisted Process for Biomedical Applications

Ghoreishi¹

2018

Int J Pharm Sci Dev Res

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Mucilage's are plant derived natural polymer which are valuable due to their nontoxicity, low cost and nonirritating nature, with wide range of applications. In this work, extracted mucilage from basil seeds (BSM) was dried using three various drying methods including (1) laboratory oven drying (2) water substitution with organic solvent and laboratory oven drying and (3) water substitution with organic solvent and supercritical carbon dioxide (SC-CO2) gel drying process. The obtained products were characterized by SEM, BET and FTIR and were compared both qualitatively and quantitatively. The results of this study show that, using SC-CO2 assisted process, the 3-D BSM nanostructured networks were obtained with the pores size diameter about 40 nm, without any agglomeration. Furthermore, specifi c area of the fi nal products was increased from 69 to 92 m2/g by SC-CO2 gel drying in compression with air gel drying. Our observations show that, the amount of solvent residual in the SC-CO2 dried product was affected by the weight of sample, CO2 addition rate and drying time. The residual amount of organic solvent (ethanol) for CO2 fl ow rate of 2 mL/min was found to be 8 ppm after 90 min drying time. The FTIR analyses indicated that the nature of fi nal product did not change during supercritical drying procedure. Overall, the ability to form 3-D structures, and bio adhesive property make BSM as a suitable low cost polysaccharide for biomedical applications such as drug delivery medium, wound dressing and also tissue engineering.Applications. Int J Pharm Sci Dev Res 3(1): 030-035. DOI: https://dx.

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Section: Mucilage Extraction Proceduresmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Generation of Porous Structure from Basil Seed Mucilage via Supercritical Fluid Assisted Process for Biomedical Applications

Ghoreishi¹

2018

Int J Pharm Sci Dev Res

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“…Khazaei et al [18] characterized the new biodegradable edible film made from OBL seed gum and revealed that it had a good potential to be used in producing edible films for various food applications. Akbari et al [19] used supercritical carbon dioxide phase inversion technique to dry the seed mucilage to form a nanometric structure and they found the bioadhesive property of seed mucilage was good and many active pharmaceutical compounds might be loaded to the resultant nanometric structure to enhance drug release. Naji-Tabasi et al [20] evaluated the potential of OBL seed gum nanoparticles as an oral delivery system for glutathione, which was fabricated by ion gelling technique and calcium was used as a crosslinking agent.…”

Section: Introductionmentioning

confidence: 99%

Application of Novel Natural Mucoadhesive Polymer in the Development of Pentoxifylline Mucoadhesive Tablets

Johnselvaraj¹,

Balasubramanian²,

Ramalingam³

2019

Int J App Pharm

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Objective: The present study was planned to develop a mucoadhesive tablet formulation of the drug pentoxifylline using natural mucoadhesive polymer from the plant Ocimum basilicum Linn. Methods: The isolated polymer was used to formulate the mucoadhesive tablets with 3 different concentrations. The tablets were formulated by using direct compression technique and evaluated for various parameters such as thickness, friability, weight variation, hardness, mucoadhesive strength, swelling index by standard methods, and the in vitro drug release studies in USP dissolution test apparatus type-II. Results: The swelling index was indirectly proportional to the polymer concentration and the tablets with a high concentration of polymer showed better mucoadhesive strength (28.5532±0.4660). The in vitro drug release showed that the drug release was indirectly proportional to the polymer concentration. The formulation F3 showed the controlled release of drug pentoxifylline (99.84±1.86) for 10 h. The mechanism of drug release was found to be Fickian diffusion and followed the zero-order kinetics, which was proved by its highest linearity (r2) in all the formulations. Conclusion: The tablets formulated with the isolated polymer of Ocimum basilicum Linn showed the good mucoadhesive mucoadhesive property and it controlled the release of the pentoxifylline.

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Novel Hydrocolloids for Future Progress in Nanotechnology

Naji‐Tabasi¹

2019

Emerging Natural Hydrocolloids

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Supercritical CO2 Generation of Nanometric Structure from Ocimum basilicum Mucilage Prepared for Pharmaceutical Applications

Cited by 9 publications

References 24 publications

Generation of Porous Structure from Basil Seed Mucilage via Supercritical Fluid Assisted Process for Biomedical Applications

Generation of Porous Structure from Basil Seed Mucilage via Supercritical Fluid Assisted Process for Biomedical Applications

Application of Novel Natural Mucoadhesive Polymer in the Development of Pentoxifylline Mucoadhesive Tablets

Novel Hydrocolloids for Future Progress in Nanotechnology

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