Supercritical Fluid and Unified Chromatography

gAn improved interface for universal acoustic flame detection in modified supercritical fluid chromatography

“…As seen, in the instance presented in Fig. 4A, modest baseline fluctuations were noted with a neat SC-CO 2 30 mm separation. Still, a fairly decent chromatogram was generated without interface heating since the purely gaseous effluent did not greatly perturb the AFD flame.…”

“…Supercritical fluid chromatography (SFC) is an established method that provides useful complimentary separation properties to those of conventional LC and GC [1,2]. The most common mobile phase employed in SFC is supercritical carbon dioxide (SC-CO 2 ) due in part to its relatively low cost, available purity, inertness, and readily attainable critical point [3,4].…”

Determination of thermodynamic properties by supercritical fluid chromatography

“…Consequently, the pressure-and density-quotients of solute retention factor (Eqs. (6) and (7)) are simply related to the correlation function integral and mean cluster size in solute-mobile phase fluid systems [100]. Fluctuation solution theory was also employed to describe solute-solute interactions as a possible source of inconsistency between thev ∞ 1m values derived from solubility measurements and those from SFC [101].…”

“…Although much of the relevant work has been covered elsewhere, e.g., in the respective sections of comprehensive reviews of analytical SFC [1][2][3] or unified chromatography [4][5][6], the field probably deserves stand-alone, periodical accounts [7] including also some specific experimental features and auxiliary thermophysical properties needed to process the chromatographic retention data. The present survey is a sequel to a short account [8] that appeared in 1991, and it largely retains the overall structure of its predecessor, comprising three major sections on thermodynamic measurements, instrumental considerations, and sources of auxiliary thermophysical data and theoretical models, respectively.…”

Cromatografia unificada

“…Os primeiros artigos envolvendo a cromatografia como uma ciência foram publicados em 1906 por Michael Tswett, um botânico russo, o qual separou algumas substâncias de extratos de plantas 1 . Desde então, esta técnica desenvolveu-se e ampliou-se até uma forma instrumental com elevada sofisticação, inicialmente com a cromatografia gasosa (GC), posteriormente, a cromatografia líquida (LC) e, finalmente, a cromatografia com fluido supercrítico 2 (SFC), concebida nos anos 60, mas empregada muito tempo depois de seu desenvolvimento.…”