Supercritical fluid assisted production of micrometric powders of the labile trypsin and chitosan/trypsin composite microparticles

Shen, Yanfeng; Guan, Yong; Yao, Shan‐Jing

doi:10.1016/j.ijpharm.2015.05.004

Cited by 17 publications

(4 citation statements)

References 38 publications

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“…The authors also observed a relative activity of 95% when the mixer was at 100 • C. It is important to call attention to the fact that no excipients were used during drying. Another study from Shen et al [101] showed the processing of trypsin in SAA-HCM. Free trypsin, without excipients, presented a relative activity of 74.3%, whereas the relative activity of trypsin from spray-drying was 66.1%.…”

Section: Biopharmaceutical Stability During Freeze-drying Spray-dryin...mentioning

confidence: 99%

Solid Dosage Forms of Biopharmaceuticals in Drug Delivery Systems Using Sustainable Strategies

et al. 2021

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Drug delivery systems (DDS) often comprise biopharmaceuticals in aqueous form, making them susceptible to physical and chemical degradation, and therefore requiring low temperature storage in cold supply and distribution chains. Freeze-drying, spray-drying, and spray-freeze-drying are some of the techniques used to convert biopharmaceuticals-loaded DDS from aqueous to solid dosage forms. However, the risk exists that shear and heat stress during processing may provoke DDS damage and efficacy loss. Supercritical fluids (SCF), specifically, supercritical carbon dioxide (scCO2), is a sustainable alternative to common techniques. Due to its moderately critical and tunable properties and thermodynamic behavior, scCO2 has aroused scientific and industrial interest. Therefore, this article reviews scCO2-based techniques used over the year in the production of solid biopharmaceutical dosage forms. Looking particularly at the use of scCO2 in each of its potential roles—as a solvent, co-solvent, anti-solvent, or co-solute. It ends with a comparison between the compound’s stability using supercritical CO2-assisted atomization/spray-drying and conventional drying.

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Section: Biopharmaceutical Stability During Freeze-drying Spray-dryin...mentioning

confidence: 99%

Solid Dosage Forms of Biopharmaceuticals in Drug Delivery Systems Using Sustainable Strategies

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Furthermore, Wang et al used this technique to prepare BSA microparticles from water solutions, obtaining different morphologies with particle diameters in the range of 0.3-5.0 µm [138]. Moreover, Shen et al applied SAA-HCM to prepare micrometric particles of trypsin from aqueous solutions, obtaining several morphologies depending on the process conditions, while also analyzing the structural stability of the protein to conclude that trypsin retained above 70% of its biological activity [140]. Moreover, polymer chitosan was used to prepare trypsin composite microparticles, obtaining spherical microparticles with a homogeneous size distribution with 90% efficiency.…”

Section: Precipitation Of Micro and Nano Protein Particlesmentioning

confidence: 99%

A Review on the Extraction and Processing of Natural Source-Derived Proteins through Eco-Innovative Approaches

2021

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In addition to their nutritional and physiological role, proteins are recognized as the major compounds responsible for the rheological properties of food products and their stability during manufacture and storage. Furthermore, proteins have been shown to be source of bioactive peptides able to exert beneficial effects on human health. In recent years, scholarly interest has focused on the incorporation of high-quality proteins into the diet. This fact, together with the new trends of consumers directed to avoid the intake of animal proteins, has boosted the search for novel and sustainable protein sources and the development of suitable, cost-affordable, and environmentally friendly technologies to extract high concentrations of valuable proteins incorporated into food products and supplements. In this review, current data on emergent and promising methodologies applied for the extraction of proteins from natural sources are summarized. Moreover, the advantages and disadvantages of these novel methods, compared with conventional methods, are detailed. Additionally, this work describes the combination of these technologies with the enzymatic hydrolysis of extracted proteins as a powerful strategy for releasing bioactive peptides.

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“…The SCF technology has created a new path in fabricating sustain delivery carriers for the transport of large molecules with structural stability. [ 18a , 24 , 82 ] Eventually, this strategy has surpassed the drawbacks of conventional processes such as solubility and recrystallization issues.…”

Section: Drug Deliverymentioning

confidence: 99%

Supercritical Fluid Technology: An Emphasis on Drug Delivery and Related Biomedical Applications

Kankala

Zhang

Wang

et al. 2017

Adv Healthcare Materials

233

184

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During the past few decades, supercritical fluid (SCF) has emerged as an effective alternative for many traditional pharmaceutical manufacturing processes. Operating active pharmaceutical ingredients (APIs) alone or in combination with various biodegradable polymeric carriers in high-pressure conditions provides enhanced features with respect to their physical properties such as bioavailability enhancement, is of relevance to the application of SCF in the pharmaceutical industry. Herein, recent advances in drug delivery systems manufactured using the SCF technology are reviewed. We provide a brief description of the history, principle, and various preparation methods involved in the SCF technology. Next, we aim to give a brief overview, which provides an emphasis and discussion of recent reports using supercritical carbon dioxide (SC-CO2) for fabrication of polymeric carriers, for applications in areas related to drug delivery, tissue engineering, bio-imaging, and other biomedical applications. We finally summarize with perspectives.

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Supercritical fluid assisted production of micrometric powders of the labile trypsin and chitosan/trypsin composite microparticles

Cited by 17 publications

References 38 publications

Solid Dosage Forms of Biopharmaceuticals in Drug Delivery Systems Using Sustainable Strategies

Solid Dosage Forms of Biopharmaceuticals in Drug Delivery Systems Using Sustainable Strategies

A Review on the Extraction and Processing of Natural Source-Derived Proteins through Eco-Innovative Approaches

Supercritical Fluid Technology: An Emphasis on Drug Delivery and Related Biomedical Applications

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