Supercritical fluid extraction of Curcuma longa and Curcuma amada oleoresin: Optimization of extraction conditions, extract profiling, and comparison of bioactivities

Compressed fluids and phytochemical profiling tools to obtain and characterize antiviral and anti-inflammatory compounds from natural sources

“…were strongly associated with anti-inflammatory activity, both in vitro and in vivo studies. In vitro, terpenes were assayed as inhibitors of lipoxygenase and proteinase [24,25], key enzymes of inflammatory pathways. In vivo, the therapeutic effect of turmeric compounds was demonstrated against periodontitis [26] and paw edema in rats [25], which was related to the synergistic action of curcuminoids, phenolic acids and volatiles present in the extract.…”

“…The use of ethanol as cosolvent (30% ethanol/70 % CO 2 ) significantly increased the yield of curcuminoids , which are lipophilic phenolic compounds [25]. In that work, authors tested methanol, ethanol, acetone and isopropanol+ethanol as modifiers, and suggested some synergistic effects of ethanol under optimum conditions (35 MPa/65 °C with 30% ethanol), such as the increase in the solvent polarity and density by the mixture CO 2 :ethanol, improving the solubility of curcuminoids; the swelling of the matrix by ethanol, which improves the mass transfer rate; and the reduction in the viscosity of the solvent [25]. Moreover, these authors optimized the conditions for Enzyme-Assisted Extraction (EAE) coupled to SFE, which resulted in a higher amount of curcuminoids.…”

“…Thus, the Curcuma oleoresins SFE extracts were subjected to LC-QTOF-MS analysis. Operating in positive ESI(+) mode, high contents of curcuminoids with anti-inflammatory capacity were tentatively identified [25]. Alternatively, accurate mass from HPLC-QTOF-MS analysis in negative ESI(-) mode allow Villalva et al [44] to confidently assign the identity of phenolic compounds selectively precipitated in the SAF process to improve the anti-inflammatory activity of the separator fractions of Achillea millefolium L. extract.…”

Curcuma longa extract improves serum inflammatory markers and mental health in healthy participants who are overweight: a randomized, double-blind, placebo-controlled trial

“…In addition, hot water extracts of C. longa were reported to prevent various chronic inflammatory diseases in animal models, including cotton pellet-induced granuloma [ 29 ], carbon tetrachloride-induced hepatitis [ 30 ], and non-alcoholic steatohepatitis [ 31 , 32 ], by decreasing the expression of genes coding for inflammatory cytokines and cell adhesion molecules. Supercritical carbon dioxide extracts of C. longa also were shown to have antioxidant activity in vitro and to inhibit carrageenan-induced inflammation in the rat paw [ 33 ]. However, the influence of a mixture of a hot water extract and a supercritical carbon dioxide extract of C. longa on chronic inflammation and general health conditions in humans is not clearly understood.…”

Properties, Extraction Methods, and Delivery Systems for Curcumin as a Natural Source of Beneficial Health Effects

“…Carbon dioxide is inert, readily available, non-toxic, non-corrosive, non-flammable, recyclable, and it is stable at mild conditions (i.e., 37 °C and 72.8 bar), which enables it to extract heat-labile compounds and also preserve their quality [ 59 ]. Nagavekar and Singhal improved the extraction efficiency upon the use of 30% ethanol as a modifier or with enzymatic before treatment with CO 2 -FSC [ 60 ].…”