Supercritical fluid extraction of spent coffee grounds: Measurement of extraction curves, oil characterization and economic analysis

Two-step sequential supercritical fluid extracts from rosemary with enhanced anti-proliferative activity

“…Several studies concerning natural products have demonstrated the viability of SFE technology (Danielski, Zetzl, Hense, & Brunner, 2005, Leal, Alexandre, Kfuri, & Meireles, 2006Leal et al, 2008;de Melo, Barbosa, Passos, & Silva, 2014;Pereira & Meireles, 2007;Prado, Assis, Maróstica, & Meireles, 2007;Rosa & Meireles, 2005). In most of this research, the cost-of-manufacturing (COM) for extracts and essential oils was lower than those produced by traditional methods and were also lower when compared to the market price of the extracts.…”

Prospective and Opportunities of High Pressure Processing in the Food, Nutraceutical and Pharmacy Market

“…Thus, optimization of design in terms of COM and test of sensitivity give a real impression of the riskiness of the project. As an example, not optimized operation conditions can affect significantly equipment cost (FCI) and hence increase the COM by 30 % (Melo et al 2014), or a 5 % increase of the interest rate can increase the pay back of the project (Fernández-Ronco et al 2013b). The raw material costs vary from values close to zero in by-products to high expenses that are affecting more COM that FCI, specially for cases where transport, heating, drying, or milling steps must be included (Leitao et al 2013;Rosa and Meireles 2005;Mezzomo et al 2011).…”

“…In the supercritical fractionation of liquid oleoresin capsicum (Fernández-Ronco et al 2012), the interest rate was determined to be the most affecting parameter on the pay-back and ROE indexes, as indicated in Table 14.4 for the Pay-Back values. Melo et al (2014) determined that an accurate definition of the separation vessel pressure has a significant impact on COM (manufacturing cost, USD/Kg extract) value, and that a 25 bar difference in this parameter can lead to a COM increase of 25 %. The effect of CO 2 recycling on the compression costs can increase the total cost of the production with 59 % (Mendes et al 2002).…”

Gac oil and carotenes production using supercritical CO2: Sensitivity analysis and process optimization through a RSM–COM hybrid approach

“…In particular, the use of SFE with CO 2 is known to bring many advantages to the production of edible oils: supercritical CO 2 (SC-CO 2 ) is non-toxic, chemically inert, inexpensive and environmentally friendly. In addition, the solvent capacity of SC-CO 2 can be tuned upon the manipulation of operating conditions of the process such as pressure and temperature, allowing the enhancement of its selectivity toward extracts richer in key molecules, and the maximization of its economic performance in terms of an improved production [4][5][6]. In addition, variables such as flow rate, particle size, or cosolvent addition are also of significant importance for attaining favorable productivity and cost effectiveness scenarios.…”

“…In this sense, the hybrid approach combining response surface methodology and cost of manufacturing (RSM-COM) aims at an optimization of operating conditions that attends to the overall SFE process, being the selected criterion the minimization of production costs, rather than the isolated yields or concentration indicators. This approach was first applied for SFE of lycopene from tomato waste [5].…”