Supercritical fluid extraction strategies of liquid-based matrices

Supercritical Fluid Extraction Enhances Discovery of Secondary Metabolites from Myxobacteria

“…Due to the relatively high pressure of 200 bar in our experiments, the CO 2 /MeOH mixture remains in the supercritical state even when increasing to an equipotential portion of the co-solvent. This is reflected in the high extraction efficiency for more polar natural products such as the cittilins and the DKxanthenes. , Our data suggests that secondary metabolites such as myxovirescin A (CLog P = 5.80), myxalamid A (CLog P = 3.40), myxochromid A3 (CLog P = 5.30), and indiacen A (CLog P = 3.68) exceeding a log P of 3 show best extraction using 20% EtOAc as a co-solvent. Secondary metabolites such as cittilin A (CLog P = 1.85), DKxanthen 560 (CLog P = 2.22), myxochelin A (CLog P = 2.34), and terrestribisamid A (CLog P = 2.34) with log P values below 3 are better extractable using more polar and protic co-solvents such as i PrOH and MeOH (see Figure ).…”

Supercritical fluid extraction tandem responsive polarity modifier separation of hydroxytyrosol rich phenolic raffinates from olive oil

“…This phenomenon allows separation of polar phenolic compounds from olive oil in an ecofriendly (green) fashion. Many different researchers have provided insights into separation of different compounds from aqueous based matrices (Ramsey et al, 1998(Ramsey et al, , 2011. However, ours is arguably the first step towards separation of phenolic compounds from oil matrix (olive oil).…”

“…The phenolic compounds present in olive oil vary in compound polarity. There are certain reports in which researchers have executed the extraction of different valuable compounds from aqueous matrices through SFE equipped with varying hardware (Ramsey et al, 1998(Ramsey et al, , 2011. However, literature on extraction of phenolic or other valuable components from liquid matrices through supercritical fluid extraction is scanty, and to the best of the authors' knowledge, there are no reports on extraction of phenolic compounds from olive oil using supercritical fluid extraction.…”

Simultaneously characterization of multiple constituents in Valeriana jatamansi Jones using an online supercritical fluid extraction‐high‐performance liquid chromatography/supercritical fluid chromatography‐mass spectrometry system

“…These combined systems offer various application advantages under different analytical conditions. The SFE-SFC system utilizes the strengths of supercritical technology to enhance analysis efficiency and accuracy [9,22,29,[34][35][36][37][38]. The SFE-HPLC system combines the supercritical technology for simplified pretreatment ability with mature sepa-ration methods to provide innovative ideas for analyzing complex component samples.…”