Supercritical Fluids and Nanoparticles in Cancer Therapy

Abstract

Nanoparticles are widely used in the pharmaceutical industry due to their high surface-to-volume ratio. Among the many techniques used to obtain nanoparticles, those based on supercritical fluids ensure reduced dimensions, narrow particle size distributions, and a very low or zero solvent residue in the powders. This review focuses on using supercritical carbon dioxide-based processes to obtain the nanoparticles of compounds used for the treatment or prevention of cancer. The scientific literature papers have been classified into two groups: nanoparticles consisting of a single active principle ingredient (API) and carrier/API nanopowders. Various supercritical carbon dioxide (scCO2) based techniques for obtaining the nanoparticles were considered, along with the operating conditions and advantages and disadvantages of each process.

Review of Carrier-Free Self-Assembly of Anticancer Nanodrugs

“…218,219 Moreover, the production of self-assembled nanodrugs in laboratories is mostly based on the nanoprecipitation method, which has too many influencing factors that make it difficult to comprehensively consider and thus arrive at the best preparation conditions, which makes the transformation to industrial mass production very difficult. This situation has improved somewhat in recent years, due to the development of various preparation methods such as spraydrying, 220,221 supercritical fluid (SCF), 222,223 and wet media milling. 224 Moreover, the release of self-assembled nanodrugs has been an important issue.…”

“…But, with the advances in molecular simulation technology, we are now able to simulate the formation of self-assembly between molecules through accurate molecular simulation models and use the results obtained from the simulations to guide further experimental design. , Moreover, the production of self-assembled nanodrugs in laboratories is mostly based on the nanoprecipitation method, which has too many influencing factors that make it difficult to comprehensively consider and thus arrive at the best preparation conditions, which makes the transformation to industrial mass production very difficult. This situation has improved somewhat in recent years, due to the development of various preparation methods such as spray-drying, , supercritical fluid (SCF), , and wet media milling …”

Dendrimers-Based Drug Delivery System: A Novel Approach in Addressing Parkinson’s Disease

“…Amongst non-invasive approaches, the most commonly used nanomaterial in neurodegenerative diseases are nanoparticles (NPs) which are under a bigger umbrella of colloidal drug carriers [29,30]. Recently, De Marco [31] reviewed the application of supercritical fluid technology to produce NPs.…”