Superfast Scan of Focused X-Ray Luminescence Computed Tomography Imaging

Fang, Yile; Zhang, Yibing; Lun, Michael C.; Li, Changqing

doi:10.1109/access.2023.3336615

Cited by 3 publications

(5 citation statements)

References 31 publications

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“…Under the fly-scanning scheme, the three photon counters constantly collected the pulse signals from each of the five PMTs in a short data collection window (10 ms) and the position information was recorded constantly, which dramatically reduced the linear scanning time. Details of the fly-scanning scheme are described in [9].…”

Section: Phantom Experimental Set-upmentioning

confidence: 99%

“…To perform multi-color XLCT imaging, we have synthesized biocompatible nanophosphors with bright and distinct x-ray luminescence spectra and compared them with commercially available nanophosphors [6]. Furthermore, we have shown that the scan time could be improved by introducing a fly-scanning scheme and a dual channel gated photon counter as data acquisition device [7], [8], [9]. However, so far there is no quantitative study of pencil beam XLCT in imaging x-ray excitable nanophosphor targets in deep scattering media.…”

Section: Introductionmentioning

confidence: 99%

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Quantitative study of x-ray luminescence computed tomography

Fang,

Zhang,

2024

Medical Imaging 2024: Clinical and Biomedical Imaging

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Pencil beam X-ray luminescence computed tomography (XLCT) is a developing hybrid molecular imaging modality combining the merits of both x-ray imaging (high spatial resolution) and optical imaging (high sensitivity). Narrow x-ray beam based XLCT imaging has shown promise for high spatial resolution imaging and high molecular sensitivity, but so far there is no quantitative study of XLCT imaging for x-ray excitable nanophosphor targets in deep tissue. In this study, we have for the first time performed quantitative study on the reconstructed nanophosphor target concentrations through phantom experiments. We have upgraded our XLCT imaging system by mounting four optical fiber cables to increase the efficiency in collecting x-ray induced optical photons. We also used a piece of scintillator crystal to monitor the x-ray pencil beam's intensity to sense automatic phantom boundary and to perform parallel beam based CT imaging simultaneously, which can be used to verify the true locations of the reconstructed XLCT targets. We have scanned a cylindrical agar phantom containing twelve targets filled with three different nanophosphor concentration (2.5 mg/ml, 5 mg/ml, and 10 mg/ml) and reconstructed XLCT images with the filtered back-projection (FBP) algorithm. We have conducted quantitative analysis of the phantom experimental results employing different numbers of optical fiber cables and found the reconstructed signals ratio is calculated to be 1: 2.17: 3.55, which is close to the ground truth target concentrations ratio of 1:2:4.

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Section: Phantom Experimental Set-upmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Quantitative study of x-ray luminescence computed tomography

Fang,

Zhang,

2024

Medical Imaging 2024: Clinical and Biomedical Imaging

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“…In the past, most of our studies utilized a single sensitivity optical photon detector [12][14][17][18]. However, the collection efficiency of excited optical photons by a single detector channel is low, consequently limiting the sensitivity and accuracy of the reconstructed XLCT images, while we have demonstrated that it is sufficient to obtain acceptable XLCT images with a single detector.…”

Section: Introductionmentioning

confidence: 99%

“…Lun et al [11] reported the successful reconstruction of a phosphor target with a concentration as low as 0.01 mg/mL at a scanning depth of 21 mm. Fang et al [12] recently reported a superfast X-ray luminescence computed tomography (XLCT) scan scheme utilizing a photon counter detector and fly-scanning method, achieving a remarkable 28.6-fold increase in speed (43 seconds per transverse scan) compared to previous methods, while maintaining improved XLCT image quality. This rapid scanning approach offers a viable method for conducting 3D X-ray Luminescence Computed Tomography (XLCT) imaging.…”

Section: Introductionmentioning

confidence: 99%

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Pencil Beam Based X-ray Luminescence Computed Tomography Imaging of Deep Targets Three-dimensionally and Quantitatively

Fang,

Zhang,

2024

Preprint

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X-ray luminescence computed tomography (XLCT), especially pencil beam based XLCT, has been emerged for more than 15 years because it can image deep targets in tissue with high spatial resolution and high measurement sensitivity. However, its application is limited by long scanning time and the tedious efforts of finite element mesh generation for model based reconstruction. Our previous study has addressed the imaging speed issue. In this study, we propose to reconstruct XLCT with weighted filtered back projection (wFBP) which makes it possible to perform XLCT imaging three dimensionally for complex objects at a high spatial resolution. We have also proposed measurements with multiple detectors to obtain quantitative XLCT images. To evaluate the proposed methods, we have performed numerical simulations and different sets of phantom experiments including phantom experiments with a control contrast target, different concentrations, and different target sizes. We have also successfully reconstructed deep targets with a diameter of approximately 0.15 mm. For the phantom experiments with targets of different concentrations, using a 4-channel XLCT system and the wFBP, we achieved the ratio of 3.8:1.79:1, closely resembling the ground truth ratio of 4:2:1. Lastly, we have, for the first time, reconstructed different 3D targets at high spatial resolution, successfully, including a printed M target, a triangular hollow bar, and a hot background cuboid with “UCM Li Lab” slots. Our results indicate that the proposed wFBP advances the promising XLCT technology and makes it ready for in vivo studies in the future.

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Oxygenation imaging of deep targets at high resolution with an x-ray luminescence micro-CT system

Zhang,

Fang,

Abbaraju

et al. 2024

Developments in X-Ray Tomography XV

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Imaging the oxygenation distribution at a high spatial resolution in deep tissues such as bone marrow is important because it helps us in understanding the oxygenation's role on stem cell proliferation and differentiation inside the bone marrow. Current technologies have limitations in imaging the oxygenation of deep targets. To overcome these limitations, x-ray Luminescence Computed Tomography (XLCT) has the potentials to image the oxygenation of bone marrow at a spatial resolution close to the focused x-ray beam size, which is better than 150 micrometers. In this study, oxygenation sensing films have been developed. Then, we have improved our XLCT imaging system by adding optical filters for measurements of photons at multiple wavelengths so that we are able to image the oxygenation of deep film targets. Then, we have conducted a phantom experiment to validate this approach. We obtained the oxygen concentration images by measuring the ratios of the XLCT images at two wavelengths.

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Superfast Scan of Focused X-Ray Luminescence Computed Tomography Imaging

Cited by 3 publications

References 31 publications

Quantitative study of x-ray luminescence computed tomography

Quantitative study of x-ray luminescence computed tomography

Pencil Beam Based X-ray Luminescence Computed Tomography Imaging of Deep Targets Three-dimensionally and Quantitatively

Oxygenation imaging of deep targets at high resolution with an x-ray luminescence micro-CT system

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