2021
DOI: 10.3390/molecules27010110
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Superfast Synthesis of Stabilized Silver Nanoparticles Using Aqueous Allium sativum (Garlic) Extract and Isoniazid Hydrazide Conjugates: Molecular Docking and In-Vitro Characterizations

Abstract: Green synthesis of silver nanoparticles (AgNPs) was synthesized from fresh garlic extract coupled with isoniazid hydrazide (INH), a commonly used antibiotic to treat tuberculosis. A molecular docking study conducted with the selected compounds compared with anthranilate phosphoribosyltransferase (trpD) from Mycobacterium tuberculosis. The aqueous extract of garlic was prepared and mixed with silver nitrate (AgNO3) solution for the superfast synthesis of stable AgNPs. INH was then conjugated with AgNPs at diffe… Show more

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Cited by 40 publications
(21 citation statements)
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“…Maximum linearity was observed for zero order ( R 2 = 0.994), while slope of Korsmeyer-Peppas equation was found 1.567. Slope greater than one indicates super case II that is drug release by diffusion and chain relaxation [ 29 ]. Drug release by chain relaxation often happens in cross-linked matrices where cross-linking strength declines with time.…”
Section: Resultsmentioning
confidence: 99%
“…Maximum linearity was observed for zero order ( R 2 = 0.994), while slope of Korsmeyer-Peppas equation was found 1.567. Slope greater than one indicates super case II that is drug release by diffusion and chain relaxation [ 29 ]. Drug release by chain relaxation often happens in cross-linked matrices where cross-linking strength declines with time.…”
Section: Resultsmentioning
confidence: 99%
“…It may be due to the hydrophilic character of HPMC, and drug release retardation was controlled by gelling and swelling nature. But the combinations of polymers yield the good sustaining effect [ 21 ]. So this study clearly proved that 1 : 1 ratios of combined polymers (HPMC and EC) have the capacity to encapsulate the drug ATN completely and provide good release retardant properties.…”
Section: Resultsmentioning
confidence: 99%
“…CuR and excipients were investigated using FT-IR to see whether there was any interaction (structural difference). In an FT-IR spectrophotometer [ 20 ] (JASCO/FT-IR-6300, Tokyo, Japan), the IR spectra of solid materials was studied in the solid powder using the KBr disc technique in the wavenumber range of 4000–400 cm −1 , with a scan speed of 1 cm −1 .…”
Section: Methodsmentioning
confidence: 99%