Superficial angiomyxoma of the breast in a 16‐year‐old girl without carney’s complex: A case report

Dubin, Iram; Mortazavi, Shabnam; Yu, Tiffany; Riahi, Irene R; Baker, Jennifer L.

doi:10.1111/tbj.14301

Cited by 5 publications

(5 citation statements)

References 10 publications

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“…On immunohistochemistry, the tumor was positive for CD34 and ERG, while EMA, SMA, S-100, Desmin, ER, and PR were negative. Histological and immunohistochemistry ndings were in line with the prior reports (5)(6)(7)(8)(9)(10)(11).…”

Section: Discussionsupporting

confidence: 90%

“…Kumar et al ( 9) reported a case with contrast-enhanced computed tomography and showing a predominantly necrotic mass in the right breast/subcutaneous plane of chest wall with no underlying muscle in ltration. And Dubin et al (11) reported a case demonstrating with a vascular, hypoechoic mass with partially circumscribed margins on ultrasonography and an enhancing, T1 hypoinense, markedly T2 hyperintense mass on chest MRI, which were in line with our ndings. And marked T2 hyperintensity on MRI which re ect the high-water content and myxoid matrix have been considered the typical imaging feature of myxoid soft-tissue lesions (12).…”

Section: Discussionsupporting

confidence: 89%

“…In cases without Carney complex, the occurrence of SAM on the breast is extremely rare. Only eight such cases have been reported (5,(7)(8)(9)(10)(11); 2 cases (25%) in males and 6 (75%) in females (all in premenopausal women); 4 cases (50.0%) on the nipple, 1 case (12.5%) in the nipple-areola complex, 2 case (25.0%) in the subcutaneous region and 1 case (12.5%) in the areola. A summary of the previously reported studies looking at SAM of the breast is listed in Table 1.…”

Section: Discussionmentioning

confidence: 99%

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Superficial angiomyxoma of the breast in a 25-year-old woman without carney’s complex: case report and literature review

Meng

Yin

Chen

et al. 2022

Preprint

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Background: Superficial angiomyxoma (SAM) is a rare, benign tumor characterized by scattered stellate or spindle cells and thin-walled blood vessels embedded in abundant myxoid stroma. It was first reported as a cutaneous myxoma associated with Carney complex in 1985, and lesions are commonly located in the eyelids, external ear canal, and nipples and often appear in multiples. In cases with no evidence of Carney complex, the incidence of breast SAM is extremely rare. Case presentation: We reported a case of a 25-year-old Chinese woman presented with a left breast lump in the subareolar region for three years and gradually increased in size. No evidence of Carney complex was noted. Breast ultrasonography (US) and magnetic resonance imaging (MRI) were undertaken with US BI-RADS 4A and MR BI-RADS 4, respectively. The patient denied biopsy and underwent a lumpectomy and was diagnosed with SAM. There was no tumor recurrence after 18 months of follow-up. Conclusion: This case report suggests that the preoperative US and MRI characteristics of breast SAM are specific and in accordance well with the histological appearances. Recognition of these imaging features may be helpful for the diagnosis of SAM. And complete excision and long-time regular follow-up after surgery are recommended.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

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Superficial angiomyxoma of the breast in a 25-year-old woman without carney’s complex: case report and literature review

Meng

Yin

Chen

et al. 2022

Preprint

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“…There is scant literature on the radiologic appearance of SAM (9)(10)(11). The best imaging modality for evaluating SAM is magnetic resonance imaging because of its excellent tissue contrast.…”

Section: Discussionmentioning

confidence: 99%

Superficial Angiomyxoma of the Wrist: Case Report and Literature Review

Chijiiwa

Nagano

Nishio

2023

In Vivo

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Background/Aim: Superficial angiomyxoma (SAM) is a rare benign soft-tissue tumor that usually occurs in the trunk, head and neck, and lower extremity of middleaged adults. Herein, we describe an unusual case of SAM of the wrist, which was initially diagnosed as a ganglion cyst on imaging. Case Report: The patient was a 71-year-old man with no history of trauma who presented with a 2-year history of a palpable mass in the left wrist. Physical examination revealed a 2.5-cm, elastic hard, mobile, nontender mass. Magnetic resonance imaging revealed a well-defined mass with iso-signal intensity relative to skeletal muscle on T1-weighted sequences and very high signal intensity on T2-weighted fat-suppressed sequences. Subtle internal enhancement was seen following gadolinium administration. Complete excision was performed under general anesthesia with tourniquet control. Histologically, the lesion was composed of bland spindle to stellate-shaped cells in an abundant myxoid stroma. Immunohistochemically, the lesional cells were positive for CD34 but negative for S-100 protein, smooth-muscle actin, desmin, epithelial membrane antigen and pancytokeratin. These findings were consistent with a diagnosis of SAM. There was no clinical evidence of recurrence during a follow-up period of 3 months. Conclusion: Although extremely rare, SAM should be considered in the differential diagnosis of a cyst-like solid lesion near small joints.

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“…4,12,13 Mutations or large deletions in PRKAR1A, or loss of PRKAR1A by immunohistochemistry, are found in both syndromic and sporadic forms of these tumor types. 4,10,11,13,14 Despite Carney and Toorkey's original description, these lesions, when occurring in breast, have not been well-characterized in subsequent literature, and there are just a few case reports of similar myxoid lesions arising in the nipple and breast, [15][16][17][18][19] described under various diagnostic terms such as myxoma of breast, nodular mucinosis, nodular/lobular myxoid change, and myxoid fibroadenoma . In our clinical practice, we have encountered cases of "superficial" angiomyxoma arising in various locations within the breast region, including in the dermis and/or subcutis, or deeper within breast parenchyma.…”

mentioning

confidence: 99%

Angiomyxoma of the Breast

Baranov

Alston²,

Lester³

et al. 2022

American Journal of Surgical Pathology

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Superficial angiomyxoma is an uncommon benign mesenchymal neoplasm that usually arises in dermis/subcutis of the extremities or trunk. Some tumors are associated with Carney complex. When arising in breast, these tumors are not wellrecognized, mainly due to a lack of uniform nomenclature in the literature. This study therefore aims to improve recognition of angiomyxomas of the breast region. Forty cases were identified: demographics, presence of Carney complex, imaging and histologic features, PRKAR1A expression, and outcomes were evaluated. There were 22 female and 18 male patients (median age 40 years, range: 14 to 72). Most tumors presented as slowlygrowing masses (77%). All but one were solitary, and median size was 1.5 cm. Tumors were superficial (dermal/subcutaneous) in 52.5% and deep/parenchymal in 47.5%. Nine involved the nippleareola complex. All showed characteristic features of superficial angiomyxoma: poorly circumscribed, hypocellular, myxoid neoplasms with lobulated (55%) or infiltrative (45%) architecture, bland spindled fibroblasts, prominent thin-walled vessels, and admixed neutrophils. Tumors involving the nipple-areola complex infiltrated through areolar smooth muscle, and deep/parenchymal tumors showed entrapment of lobules mimicking myxoid fibroadenoma. Mitoses were typically absent, as was significant atypia. Cystic change was common. Two-thirds showed loss of PRKAR1A expression by immunohistochemistry. Two patients had Carney complex (7%). Recurrence after incomplete excision occurred in 1 patient. Angiomyxoma of breast may arise at superficial, nipple-areola or deep/parenchymal locations, where it can be difficult to recognize classic histologic features. Loss of expression of PRKAR1A is not invariable, but may be a helpful diagnostic clue. Recognizing angiomyxoma is important for 2 reasons: first, the recurrence rate is low and therefore wide excision is not essential, and second, it may allow detection of Carney complex in some patients.

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Superficial angiomyxoma of the breast in a 16‐year‐old girl without carney’s complex: A case report

Cited by 5 publications

References 10 publications

Superficial angiomyxoma of the breast in a 25-year-old woman without carney’s complex: case report and literature review

Superficial angiomyxoma of the breast in a 25-year-old woman without carney’s complex: case report and literature review

Superficial Angiomyxoma of the Wrist: Case Report and Literature Review

Angiomyxoma of the Breast

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