Superficial CD34-positive fibroblastic tumor (SCPFT): A review of pathological and clinical features

Salah, Haneen; D'ardis, Julieta A; Baek, Donghwa; Schwartz, Mary R.; Ayala, Alberto G.; Ro, Jae Y.

doi:10.1016/j.anndiagpath.2022.151937

Cited by 14 publications

(4 citation statements)

References 19 publications

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“…Soft tissue neoplasms of fibroblastic and myofibroblastic origin are categorized as benign, intermediate, and malignant depending on their clinical behavior, local recurrence, and metastatic potential. SCDPFBT is classified as an intermediate-grade (low-grade), rarely metastasizing tumor [3,6]. To date, less than 100 cases have been reported, owing to its rarity along with lack of familiarity and recognition among pathologists [7].…”

Section: Discussionmentioning

confidence: 99%

Superficial CD34-Positive Fibroblastic Tumor: A Case Series and a Review of Literature

Zafar,

Nasir,

Zaman

2023

Cureus

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Superficial CD34-positive fibroblastic tumor (SCD34PFBT) is a recently recognized neoplasm of mesenchymal origin. Only a few cases have been reported in the literature so far. Microscopically, it consists of a dermal spindle cell neoplasm, with low mitotic activity, arranged in a fascicular pattern. The individual neoplastic cells show marked nuclear atypia, nuclear pseudo-inclusions, and dense eosinophilic cytoplasm. The tumor cells characteristically show positivity for CD34 immunohistochemical stain. This tumor behaves as a low-grade malignancy with potential to recur locally, with rare cases showing lymph node metastasis. Wide local excision and regular follow-up are the currently followed steps for management. This tumor serves as a diagnostic challenge due to its overt atypia, and it can be misdiagnosed as a sarcoma. Recognition of this entity among pathologists is important due to this reason. We hereby report four cases of this newly recognized entity.

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Section: Discussionmentioning

confidence: 99%

Superficial CD34-Positive Fibroblastic Tumor: A Case Series and a Review of Literature

Zafar,

Nasir,

Zaman

2023

Cureus

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“…Mohs micrographic surgery, marginal excision, wide excision, and excisional biopsy have been used as the primary surgical method. 4,9,10 None of the reported patients with local recurrence underwent initial definitive surgical resection margin. In a previously reported case of SCPFT with local recurrence, an incomplete excision was performed, and the time to the first recurrence was 31 months.…”

Section: Discussionmentioning

confidence: 99%

“…The mainstay treatment for this tumor is surgical resection. Mohs micrographic surgery, marginal excision, wide excision, and excisional biopsy have been used as the primary surgical method 4,9,10 . None of the reported patients with local recurrence underwent initial definitive surgical resection margin.…”

Section: Discussionmentioning

confidence: 99%

Case of recurrent superficial CD34‐positive fibroblastic tumor

et al. 2022

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Superficial CD34-positive fibroblastic tumor (SCPFT) is a recently described rare superficial mesenchymal tumor. SCPFT has a distinctive morphologic appearance, marked by significant nuclear pleomorphism, low mitotic rate, and diffuse CD34 positivity. SCPFT is underdiagnosed because of its rarity and misdiagnosis as sarcoma, with very few reported cases of local recurrence or metastasis. Recognition and awareness of SCPFT are essential for accurate diagnosis and appropriate clinical management. We describe here the case of a 37-year-old male who presented with a right calf mass diagnosed as SCPFT with subsequent local recurrence of the tumor.

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“…Microscopically, SCPFTs are composed of spindled to epithelioid cells arranged in a fascicular pattern. The tumor cells show apparent cellular heterogeneity and prominent nucleoli with apparent CD34 positivity (4).…”

Section: Introductionmentioning

confidence: 99%

Superficial CD34⁺ fibroblastic tumor with focal atypical presentation: A case report

Sun,

Huang,

Yang

2024

Oncol Lett

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Superficial CD34 + fibroblastic tumors (SCPFTs) are rare mesenchymal tumors with distinct morphological features. Although several cases of SCPFT have been reported, a comprehensive understanding of its clinical and biological features necessitates the inclusion of additional cases. The current study presents a case of SCPFT, where morphological observations, immunohistochemical staining and fluorescence in situ hybridization (FISH) were performed. Immunohistochemistry revealed diffuse CD34 expression and integrase interactor 1 expression, whilst FISH indicated rearrangement of the PR/SET domain 10 gene. Microscopic assessment demonstrated typical SCPFT pathology, with a focal nodular region showing a high Ki-67 index, suggesting heterogeneity and the potential for local recurrence. The present study also briefly reviews the differential diagnosis of tumors with morphological similarities. It was found that the precise diagnosis of SCPFT relies on the distinctive pathological features, the use of immunohistochemical markers, including CD34 staining, and the differentiation from similar histological lesions.

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Superficial CD34-positive fibroblastic tumor (SCPFT): A review of pathological and clinical features

Cited by 14 publications

References 19 publications

Superficial CD34-Positive Fibroblastic Tumor: A Case Series and a Review of Literature

Superficial CD34-Positive Fibroblastic Tumor: A Case Series and a Review of Literature

Case of recurrent superficial CD34‐positive fibroblastic tumor

Superficial CD34⁺ fibroblastic tumor with focal atypical presentation: A case report

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Superficial CD34-positive fibroblastic tumor (SCPFT): A review of pathological and clinical features

Cited by 14 publications

References 19 publications

Superficial CD34-Positive Fibroblastic Tumor: A Case Series and a Review of Literature

Superficial CD34-Positive Fibroblastic Tumor: A Case Series and a Review of Literature

Case of recurrent superficial CD34‐positive fibroblastic tumor

Superficial CD34+ fibroblastic tumor with focal atypical presentation: A case report

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Superficial CD34⁺ fibroblastic tumor with focal atypical presentation: A case report