Superficial foveal avascular zone area changes before and after idiopathic epiretinal membrane surgery

Yoon, Yo Sep; Woo, Je Moon; Woo, Jong Eun; Min, Jung Kee

doi:10.18240/ijo.2018.10.21

Cited by 16 publications

(6 citation statements)

References 26 publications

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“…Our results confirmed the negative correlation between FAZ area and CFT in both control and ERM groups. Similar results have been reported in Japanese and American studies [ 15 , 17 , 18 ]; additionally, these previous studies found that foveal thickness decreased following vitrectomy. Moreover, foveal thickness was higher in the ERM eyes than in normal eyes, indicating that the tractional effects of ERM might persist even after its removal.…”

Section: Discussionsupporting

confidence: 91%

“…The integrity of the ellipsoid zone was significantly correlated to postoperative vision [ 15 ]. Additionally, the final effect of the operation depends on changes of the foveal vasculature, which disperses the light before it reaches the photoreceptor cells [ 18 ]. Measurement of FAZ area in patients with ERM is paramount, because the degree of metamorphopsia is significantly correlated with the area of FAZ in these patients [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

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Idiopathic Epiretinal Membrane: Microvasculature Analysis with Optical Coherence Tomography and Optical Coherence Tomography Angiography

et al. 2022

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Background: The present study examined the relationships among macular microvasculature, retinal structure, and epiretinal membrane (ERM) and explored the utility of optical coherence tomography (OCT) angiography (OCTA) in idiopathic ERM assessment. Methods: The study sample comprised 276 eyes of 276 patients. A total of 154 eyes with ERM and 122 normal (control) eyes were analyzed. Only one eye of each participant was randomly selected for posterior segment imaging. Each patient underwent OCT and OCTA. Images were analyzed with AngioTool 0.6. Results: Foveal avascular zone was significantly smaller in the ERM group (p = 0.044). Average retinal thickness and foveal thickness were significantly higher in the ERM group (both p = 0.001). Moreover, 64 (41.5%) patients exhibited no metamorphopsia, while 46 (29.8%) and 44 (28.7%) patients exhibited moderate and extensive metamorphopsias, respectively. Meanwhile, FAZ was negatively correlated with central retinal thickness in the ERM group. The vessel area (p = 0.0017) and vessel percentage area (p = 0.044) were significantly greater in the ERM group. Conclusions: Changes observed in the superficial plexus in OCTA are related to the severity of metamorphopsia and can be further evaluated to support decision making regarding the surgical management of idiopathic ERM.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Idiopathic Epiretinal Membrane: Microvasculature Analysis with Optical Coherence Tomography and Optical Coherence Tomography Angiography

et al. 2022

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“…IERM exposes the macula to anteroposterior and tangential stresses, resulting in macula thickening and vascular shift [ 14 , 26 ]. Previous studies identified OCT predictors for structural and functional outcomes after surgery, such as the thickness of the inner nuclear layer and CMT and defects of the interdigitation zone and ellipsoid zone [ 27–30 ].…”

Section: Discussionmentioning

confidence: 99%

A classification of idiopathic epiretinal membrane based on foveal avascular zone area using optical coherence tomography angiography

Zhang,

Mao,

Lao

et al. 2024

Annals of Medicine

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Objective To evaluate the characteristics and prognoses of idiopathic macular epiretinal membrane (iERM) using a classification based on the foveal avascular zone (FAZ) area. Method IERMs were classified into four stages based on the FAZ area. Baseline FAZ-related parameters, pre-and postoperative central macular thickness (CMT), and best corrected visual acuity (BCVA) were observed and compared between different stages. The correlations of structural parameters with pre-and postoperative logMAR BCVA were analyzed. Results 162 iERM eyes were enrolled, including 105 eyes followed up for 12 months after surgery. The preoperative BCVA was better at the early stage. Postoperative BCVA at Stages 2 and 3 were better compared to Stage 4. The early stage was associated with thinner CMT pre-and postoperatively. However, there was no significant difference in CMT between postoperative Stages 1 and 2 or Stages 3 and 4. Preoperative logMAR BCVA was negatively correlated with FAZ area, perimeter, and FD-300 and was positively correlated with CMT and acircularity index (AI). CMT correlated positively with BCVA for each stage, except Stage 4; FAZ area, perimeter, and FD-300 had a negative correlation at Stage 1. Baseline BCVA and CMT positively correlated with BCVA at the last follow-up, while FAZ area and FD-300 were negatively correlated. Baseline BCVA had a positive correlation for each stage, except Stage 1; FD-300 had a negative correlation at Stages 2 and 3; CMT had a positive correlation at Stage 3. Conclusion A classification based on the FAZ area was established innovatively. This classification can reflect the progression of iERM and is helpful to the postoperative prognosis.

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“…However, iERM contraction or shrinkage can cause foveal displacement. This can result in the loss of light dispersion due to vessel displacement ( 12 ), and light propagation anomalies due to muller cell deformation ( 13 – 15 ). Daiki et al ( 16 ) proposed tangential displacement as a parameter for characterizing tangential morphological alterations in the outer retina.…”

Section: Introductionmentioning

confidence: 99%

Total and horizontal distances of the foveal stereotaxic displacement can be prognostic indicators for patients with idiopathic epiretinal membrane

Zhang

Mao²,

Lao³

et al. 2023

Front. Med.

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IntroductionThis study aimed to examine the foveal stereo deviations in the different ectopic inner foveal layer (EIFL) stages of idiopathic epiretinal membrane (iERM) and assess its predictive utility for the baseline and postoperative best-corrected visual acuity (BCVA).MethodsBased on the calculational combination of foveal displacements in the horizontal and vertical axial optical coherence tomography (OCT) images, the foveal stereotaxic displacement was estimated through the total distance (TD, the distance from the foveal bottom to the inner edge of displaced central foveal) and horizontal distance (HD, projection of the TD in the retinal plane). The preoperative TD, HD, and other OCT- and OCT angiography (OCTA)-related indicators were obtained. The correlations between structural parameters and baseline and postoperative BCVA were evaluated through correlation and multiple linear regression analyses.ResultsIn patients with advanced EIFL stage, there was a significant increase in the HD, TD, baseline log of the minimum angle of resolution unit for BCVA, central macular thickness (CMT), acircularity index, and incidence of microcystic macular edema (MME; p < 0.05). Further, they showed a decreased foveal avascular zone (FAZ) area and perimeter (p < 0.001). HD, TD, CMT, MME, FAZ area, and FAZ perimeter were significantly correlated with the baseline and postoperative BCVA (p < 0.05). TD had the highest correlation indexic and was an individual predictor of the baseline and postoperative BCVA. Moreover, FD-300 and MME were individual predictors of postoperative BCVA.DiscussionStereoscopic foveal deviations significantly correlated with the baseline and postoperative visual acuity. TD may be used as an independent prognostic factor for BCVA.

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Superficial foveal avascular zone area changes before and after idiopathic epiretinal membrane surgery

Cited by 16 publications

References 26 publications

Idiopathic Epiretinal Membrane: Microvasculature Analysis with Optical Coherence Tomography and Optical Coherence Tomography Angiography

Idiopathic Epiretinal Membrane: Microvasculature Analysis with Optical Coherence Tomography and Optical Coherence Tomography Angiography

A classification of idiopathic epiretinal membrane based on foveal avascular zone area using optical coherence tomography angiography

Total and horizontal distances of the foveal stereotaxic displacement can be prognostic indicators for patients with idiopathic epiretinal membrane

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