Superficial Leiomyosarcoma Treated With Mohs Micrographic Surgery

Humphreys, Tatyana R.; Finkelstein, David H.; Lee, Jason B.

doi:10.1111/j.1524-4725.2004.30018.x

Cited by 28 publications

(14 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Although superficial lesions may show associated skin changes such as discoloration, ulceration and umbilication, 2,4,16,29 clinical impressions might include not only benign lesions, such as a lipoma, cyst, keloid, nevus, dermatofibroma and neurofibroma 3,23,29 but also malignant entities such as basal cell carcinoma, squamous cell carcinoma, dermatofibrosarcoma protuberans and malignant fibrous histiocytoma. 3,29,32,34 This study likewise showed a heterogenous list of clinical differential diagnoses, reinforcing the suggestion that the clinical appearance of SLMS is not at all specific and may not necessarily raise the suspicion of a malignancy.…”

Section: Discussionsupporting

confidence: 71%

Superficial leiomyosarcoma: a clinicopathologic review and update

et al. 2009

View full text Add to dashboard Cite

SLMSs are rare but important smooth muscle tumors of the skin. The clinical presentation may be non-specific. The histologic appearance is that of a smooth muscle lesion, but epidermal hyperplasia and thickened collagen bands are previously underrecognized features. Immunohistochemical stains are useful in confirming smooth muscle differentiation, but CD117 is of limited utility. SLMS can appear low grade or even benign on superficial biopsies, leading to undergrading or a delay in the correct diagnosis. Clinicians and pathologists alike should therefore be aware of these pitfalls and must approach these cases with caution.

show abstract

Section: Discussionsupporting

confidence: 71%

Superficial leiomyosarcoma: a clinicopathologic review and update

et al. 2009

View full text Add to dashboard Cite

show abstract

“…[20] Narrow margin excision[13] and even Mohs micrographic surgery have also been used. [10, 11, 28] While several small case series using Mohs resection have been described, recurrences have been reported with long-term follow up. Heuther and colleauges reported a 14% incidence of recurrence when treating a spindle cell neoplasms of the skin such as cutaneous LMS with Mohs micrographic technique.…”

Section: Discussionmentioning

confidence: 99%

“…A variety of margins have been described as being appropriate for resection in the literature including narrow excision, wide excision or even Mohs micrographic surgery. [10-14] However, no consensus as to the most appropriate margin of resection currently exists. We have found that standardization of the surgical margin of resection to be useful at our own institution when treating other rare soft tissue tumors, such as dermatofibrosarcoma protuberans.…”

Section: Introductionmentioning

confidence: 99%

Cutaneous Leiomyosarcoma: Treatment and Outcomes with a Standardized Margin of Resection

et al. 2013

View full text Add to dashboard Cite

Introduction Cutaneous leiomyosarcoma (LMS) is a rare dermal-based tumor for which treatment algorithms have been poorly defined. We report our single institution experience treating cutaneous LMS using a median of a 1 cm margin for resection. Methods An IRB approved review of patients with cutaneous LMS from 2005-2010 was performed with outcomes reported. Results 33 patients with cutaneous LMS were treated, 76% were male, 97% were Caucasian with a median age of 63.5 years. 67% of tumors were located on the extremities. Pre-operative staging was negative for distant metastasis in all patients. 88% of tumors were low grade with a median tumor size of 1.3 cm. 100% of tumors tested for smooth muscle actin were positive. A majority (94%) of patients underwent primary surgical resection with a median margin of 1 cm. Final resection margin was negative in 32/33 (97%). Adjuvant radiotherapy was used in 15%. There were no recurrences or metastastic spread and 100% were alive at last follow up, median of 15.5 months. Conclusions Cutaneous LMS is primarily a low-grade malignancy affecting elderly male Caucasians. Good oncologic control and an excellent outcome are possible with a 1 cm resection margin in the vast majority of cases.

show abstract

“…Mohs micrographic surgery has been used in the management of superficial leiomyosarcomas with a reported recurrence rate of 0-14%. [19–21] In the largest series including 11 patients treated with Mohs surgery, Starling et al .,[20] reported that after a median follow-up of 4.47 years no tumor recurrences were detected. The average tumor size was 4.69 cm 2 and the average size of the surgical defect was 14.95 cm 2 .…”

Section: Discussionmentioning

confidence: 99%

Recurrent subcutaneous trunk leiomyosarcoma: Management and review of the literature

Salemis¹

2013

J Nat Sc Biol Med

View full text Add to dashboard Cite

Superficial leiomyosarcomas are rare malignant smooth-muscle tumors accounting for 4-6.5% of all soft-tissue sarcomas, less than 2-3% of cutaneous soft-tissue neoplasms and 0.04% of all cancers. They are divided into cutaneous or dermal and subcutaneous leiomyosarcomas. Subcutaneous tumors have been reported to be associated with an increased risk of local recurrences and distant metastases, compared to their cutaneous counterparts. In this study, we describe a rare case of a recurrent subcutaneous trunk leiomyosarcoma in a 68-year-old male patient. Local recurrence developed two years after the complete surgical resection with wide margins and adjuvant postoperative radiotherapy. The management of the patient is discussed along with a review of the literature. We conclude that subcutaneous leiomyosarcoma is a rare clinical entity which may be associated with an atypical clinical presentation. Physicians should be aware of the misleading features of this tumor in order to avoid delay in diagnosis and treatment. Early complete surgical resection with wide margins of at least 2 cm is the cornerstone of treatment and has been reported to mostly influence the prognosis. However, the tumor has a high tendency to recur locally and metastasize. Recurrence may develop despite wide resection and radiotherapy. Long-term follow-up is mandatory.

show abstract

Superficial Leiomyosarcoma Treated With Mohs Micrographic Surgery

Cited by 28 publications

References 19 publications

Superficial leiomyosarcoma: a clinicopathologic review and update

Superficial leiomyosarcoma: a clinicopathologic review and update

Cutaneous Leiomyosarcoma: Treatment and Outcomes with a Standardized Margin of Resection

Recurrent subcutaneous trunk leiomyosarcoma: Management and review of the literature

Contact Info

Product

Resources

About