Superficial margins in skin sparing and nipple sparing mastectomies for DCIS: A margin of potential concern

Tramm, Trine; Christiansen, Peer; Offersen, Birgitte Vrou; Madsen, Karen Berenth; Poortmans, Philip; Kaidar‐Person, Orit

doi:10.1016/j.radonc.2021.06.018

Cited by 9 publications

(1 citation statement)

References 36 publications

(49 reference statements)

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“…Nowadays, breast RT is done with CT-based planning, and for modern RT planning it mandates target volume delineation for planning and appreciation of the RT plan. The aim of target volume delineation is not to include the outdated field-encompassed volumes that were encompassed by the 2D-bony landmarks fields [ 7 , 8 ], but rather to define the true target volumes, based on anatomy, histology and in depth understanding of breast cancer biology and therapy including the surgical procedure [ 7 , 37 , 38 ]. Large RT volumes, high radiation dose, and inhomogeneous dose delivery were shown to increase breast RT-related toxicity [ [9] , [10] , [11] , 39 ].…”

Section: Introductionmentioning

confidence: 99%

The King is in the altogether: Radiation therapy after oncoplastic breast surgery

Kaidar-Person,

Offersen,

Tramm

et al. 2023

The Breast

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Section: Introductionmentioning

confidence: 99%

The King is in the altogether: Radiation therapy after oncoplastic breast surgery

Kaidar-Person,

Offersen,

Tramm

et al. 2023

The Breast

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A BRILLIANT-BRCA study: residual breast tissue after mastectomy and reconstruction

Kaidar-Person,

Faermann,

Polikar

et al. 2024

Breast Cancer Res Treat

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Introduction Different types of mastectomies leave different amounts of residual breast tissue. The significance of the residual breast volume (RBV) is not clear. Therefore, we developed an MRI tool that allows to easily assess the RBV. In this study we evaluated factors associated with RBV after skin or nipple sparing mastectomy (SSM/NSM) in breast cancer BRCA pathogenic variant (PV) carriers who underwent both therapeutic and risk reducing SSM/NSM and its relation to breast cancer outcomes using an innovative MRI-based tool. Methods Data of breast cancer BRCA PV who were treated between 2006 and 2020 were retrieved from of the oncogenetics unit databases. Only patients who underwent SSM/NSM and had a postoperative breast MRI available for analysis were included. Data collected included demographics, clinicopathological features, and outcomes. The MRI tool was developed by a breast cancer imaging laboratory. A logistic regression test and 95% confidence interval (CI) were used to assess the associated risk of increased RBV. A forward stepwise linear regression was used to correlate tumour-patient specific factors and RBV, and a Kaplan–Meier curve to show the probability of locoregional relapse. Results A total of 84 patients undergoing 89 mastectomies were included. At a median follow-up of 98 months, 5 local, 2 regional, and 4 distant recurrences were observed. RBV was not significantly related with breast cancer outcomes (p value = NS). A higher body mass index (BMI) was associated with a higher RBV (p < 0.0001). A larger number of involved axillary nodes was associated with a smaller RBV (p = 0.025). The RBV on the risk-reducing mastectomy side was significantly higher compared to the breast cancer side (p value = 0.007). Local recurrences occurred in the vicinity of the primary tumour.

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Optimising post-operative radiation therapy after oncoplastic and reconstructive procedures

Tramm¹,

Kaidar‐Person²

2023

The Breast

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Superficial margins in skin sparing and nipple sparing mastectomies for DCIS: A margin of potential concern

Cited by 9 publications

References 36 publications

The King is in the altogether: Radiation therapy after oncoplastic breast surgery

The King is in the altogether: Radiation therapy after oncoplastic breast surgery

A BRILLIANT-BRCA study: residual breast tissue after mastectomy and reconstruction

Optimising post-operative radiation therapy after oncoplastic and reconstructive procedures

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