Superficial mycoses in immunodepressed patients (AIDS)

IL-23 and IL-17A, but Not IL-12 and IL-22, Are Required for Optimal Skin Host Defense against Candida albicans

“…These findings have direct implications for human disease because they help provide an explanation for the increased susceptibility to C. albicans in patients who suffer from Job's syndrome, chronic mucocutaneous candidiasis, and HIV/AIDS (2, 23, 24, 28). It has recently been described that defective immune responses in Job's syndrome result from a defect in the ability to make Th17 cells due to mutations in STAT3 , a transcription factor essential for Th17 cell differentiation (20, 21, 29).…”

“…Although many infections occur in warm, moist areas of the body, such as in the inguinal and inframammary folds, in otherwise healthy individuals, cutaneous candidiasis is also an important marker of innate or acquired immune dysfunction. For example, individuals with diabetes mellitus, HIV disease, chronic systemic corticosteroid usage, or chemotherapy-induced neutropenia are predisposed to cutaneous candidiasis (2–5). This diverse range of clinical settings associated with susceptibility to candidiasis fits with what is currently known about immune responses directed against C. albicans , as host defense against this pathogen involves complex coordination of both innate and acquired immune responses.…”

Dermatophytosis in patients with human immunodeficiency virus infection: Clinical aspects and etiologic agents

“…In individuals with human immunodeficiency virus (HIV) infection, the clinical presentation of dermatophytosis seems to greatly vary (Ramos-e-Silva et al, 2010). Unusual forms of tinea capitis in adults, tinea faciei, lesions with dermal involvement, and atypical, extensive and disseminated lesions are reported more often, mainly in association with the immunosuppression stage of HIV infection (Aly and Berger, 1996;Rosatelli et al, 1997;Burkhart et al, 2003;Venkatesan et al, 2005;Khambaty and Hsu, 2010).…”

Clotrimazole nanoparticle gel for mucosal administration

“…When this organism proliferates, it may produce symptomatic infections ranging from relatively trivial conditions, such as oral and genital thrush, to crucial, systemic super infections in immunodepressed and chemotherapy patients [5,6].…”