Superficial papular neuroma: Case series of a new entity

Chen, Stephanie J.T.; Patel, Rajiv M.; Hans, Christine P.; Chan, May P.; Fullen, Douglas R.

doi:10.1111/cup.12981

Cited by 4 publications

(3 citation statements)

References 26 publications

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“…We observed this feature in 63 (11.3%) plaques. This alteration has also been observed in a cutaneous neural lesion that shows some similarities with the SNP [23].…”

Section:  Discussionsupporting

confidence: 59%

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Subgemmal neurogenous plaques of the tongue: a systematic autopsy study

Val‐Bernal

Garijo²,

Fontanil³

2022

Rom J Morphol Embryol

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There is no evaluation of the prevalence of this structure in the general population. We present a systematic study of samples obtained at random from the dorsal portion of the oral tongue in 205 consecutive complete autopsies. Each sample was about 15 mm long and 10 mm thick. Four hundred fifty-eight samples were routinely obtained and an average of 2.23±0.88 samples per case (range 1–7) was collected. The total number of SNPs observed was 556, with a mean of 2.71±2.68 per case (range 0–16). This means that for every 15 linear mm of the oral tongue, approximately 2.7 SNPs can be present. SNPs display several ages, and they do not show sex differences. The mean size of these structures was 2.1±0.94 mm (range 0.6–3.6 mm). SNP is characterized by its unique neural, zonal pattern with a superficial neurofibroma-like area and a deeper neuroma-like area. Special features of the SNPs include the presence of taste buds (49.1%), ganglion cells (26.3%), dilated thin-walled vessels (11.3%), salivary gland excretory ducts emptying on the surface of the papillae (6.1%), moderate-severe inflammatory infiltrate (6.8%), presence of lymphoid tissue in the vicinity (7.0%), and hyperplasia of the epithelial cover with pseudoepitheliomatous appearance (7.0%). The differential diagnoses include schwannoma, neurofibroma, ganglioneuroma, traumatic neuroma, mucosal neuroma, and squamous cell carcinoma. SNPs are small, normal structures that may undergo hyperplasia and are usually seen incidentally.

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“…We observed this feature in 63 (11.3%) plaques. This alteration has also been observed in a cutaneous neural lesion that shows some similarities with the SNP [23].…”

Section:  Discussionsupporting

confidence: 59%

“…We observed this feature in 63 (11.3%) plaques. This alteration has also been observed in a cutaneous neural lesion that shows some similarities with the SNP [ 23 ]. The excretory ducts of the minor salivary glands normally empty into the furrows or moats of the papillae.…”

Section: Discussionmentioning

confidence: 56%

Subgemmal neurogenous plaques of the tongue: a systematic autopsy study

Val‐Bernal

Garijo²,

Fontanil³

2022

Rom J Morphol Embryol

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“…Superficial papular neuroma (SPN) is a rare, benign cutaneous nerve sheath tumor that was first described by Chen et al 1 Since their collective report of 4 cases, no new cases have been reported. Clinically, SPN appears as a solitary 2–6 mm skin-colored papule resembling a nevus or cyst.…”

Section: Introductionmentioning

confidence: 99%

A Case of Superficial Papular Neuroma: A Rare Neural Neoplasm

Suzuki,

Fukumoto,

Hiraki

et al. 2023

The American Journal of Dermatopathology

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A case of 67-year-old male patient with superficial papular neuroma (SPN) on the occiput is reported. This is the second report of SPN and the first with clinical images. Histologically, in the superficial dermis and periadnexa, the specimen exhibits a nodule of bland spindle cells with an S-shaped and spindle nucleus, surrounded by eosinophilic collagen fibers and scattered mast cells, which forms focally peripheral nerve-like structures. Lichen simplex chronicus-like changes are observed. Immunostaining result revealed that the tumor cells are positive for S-100, neurofilament, collagen IV, and CD34 but negative for Melan A, epithelial membrane antigen, and glial fibrillary acidic protein. Histological differential diagnosis includes prurigo nodularis, neurotized nevus, benign peripheral nerve sheath tumor, such as neurofibroma or schwannoma, a type of neuroma, such as traumatic neuroma, mucosal neuroma, and palisaded encapsulated neuroma, or a type of neural hamartoma. A careful histological investigation will enable dermatopathologists to make a diagnosis of SPN.

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