Superficial siderosis of the CNS: Report of three cases and review of the literature

Miliaras, George; Bostantjopoulou, Sevasti; Argyropoulou, Maria I.; Kyritsis, Athanasios P.; Polyzoidis, Konstantinos S.

doi:10.1016/j.clineuro.2005.01.014

Cited by 25 publications

(34 citation statements)

References 15 publications

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“…In 1 case report, a patient who underwent resection of an astrocytoma from the cerebellar vermis developed symptomatic superficial siderosis 29 years later. 22 The longest reported delay in onset of symptoms has been 37 years, demonstrating the chronicity of the disease and a large potential window for intervention. 21 The 3 patients in the current report developed symptoms severe enough to warrant investigation 4, 5, and 26 years, respectively, after the initial intervention.…”

Section: Discussionmentioning

confidence: 99%

Superficial siderosis of the central nervous system associated with incomplete dural closure following posterior fossa surgery: report of 3 cases

Kumar¹,

Jacob²,

Welker

et al. 2015

JNS

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This report reviews a series of 3 patients who developed superficial siderosis following posterior fossa operations in which dural closure was incomplete. In all 3 patients, revision surgery and complete duraplasty was performed to halt the progression of superficial siderosis. Following surgery, 2 patients experienced resolution of their CSF xanthochromia while 1 patient had reduced CSF xanthochromia. In this paper the authors also review the etiology, pathophysiology, diagnosis, and treatment of this condition. The authors suggest that posterior fossa dural patency and pseudomeningocele are risk factors for the latent development of superficial siderosis and recommend that revision duraplasty be performed in patients with posterior fossa pseudomeningoceles and superficial siderosis to prevent progression of the disease.

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Section: Discussionmentioning

confidence: 99%

Superficial siderosis of the central nervous system associated with incomplete dural closure following posterior fossa surgery: report of 3 cases

Kumar¹,

Jacob²,

Welker

et al. 2015

JNS

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“…Superficial siderosis (SS) of the central nervous system (CNS) is a rare disease that produces haemosiderin deposition in the subpial layers of the brain and spinal cord due to chronic and repeated haemorrhaging into the subarachnoid space, leading to progressive and irreversible cerebellar ataxia, auditory disturbance and dementia [1][2][3][4][5][6][7][8]. The causes of SS include a prior intradural surgery, carcinoma, arteriovenous malformation, amyloid angiopathy and fluid collection in the spinal canal [1][2][3]8].…”

Section: Introductionmentioning

confidence: 99%

CSF tau protein is a useful marker for effective treatment of superficial siderosis of the central nervous system: Two case reports

Ikeda

Noto

Noguchi‐Shinohara

et al. 2010

Clinical Neurology and Neurosurgery

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We report two cases of superficial siderosis (SS) of the central nervous system (CNS), which is caused by chronic haemorrhaging into the subarachnoid space with haemosiderin deposition in the superficial portion of the CNS. Patient 1 had fluid collection in the spinal canal, which was reported as the source of the chronic bleeding. Patient 2 was bleeding from thickened dura at the level of the sacral vertebrae. Both of the patients had xanthochromic cerebrospinal fluid. We surgically repaired the sources of bleeding. Subsequently the cerebrospinal fluid (CSF) cleared and their symptoms were not aggravated for about one year. We measured several CSF markers of SS before and after surgery. Total tau protein (CSF-t-tau), phosphorylated tau protein (CSF-p-tau), iron (CSF-iron) and ferritin (CSF-ferritin) in the CSF were highly elevated at diagnosis. After surgery, the levels of CSF-t-tau and CSF-p-tau were markedly reduced while CSF-iron and CSF-ferritin had not decreased. It is suggested that CSF-t-tau and CSF-p-tau reflected the neural damage in SS and were useful to evaluate the effectiveness of SS therapies.-2 -CSF tau protein in superficial siderosis

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“…Several reports describe suggested interventions for SSCN (15,41,42), including surgical ablation of the bleeding source and iron chelation therapy (43). Avoidance of anticoagulant and antiplatelet medications, including aspirin, has been suggested to slow bleeding into the subarachnoid space (20).…”

Section: Treatment: Medical and Surgicalmentioning

confidence: 99%

Superficial Siderosis of the Central Nervous System

Sydlowski¹,

Cevette²,

Shallop³

2011

Otology &Amp; Neurotology

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SSCN is a destructive disorder affecting the auditory-vestibular system. Although not a common diagnosis, SSCN may be more prevalent than clinicians realize. Site of lesion may be anywhere within the auditory-vestibular system from the inner ear to the cortex, although the cochleovestibular nerve and cerebellum are particularly vulnerable. The progressive retrocochlear nature of the disorder makes differential diagnosis difficult and development of effective treatment options challenging. It is essential that audiologists and otologists recognize this uncommon cause of sensorineural hearing loss and balance disorder and the implications for evaluation, treatment, and counseling.

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Superficial siderosis of the CNS: Report of three cases and review of the literature

Cited by 25 publications

References 15 publications

Superficial siderosis of the central nervous system associated with incomplete dural closure following posterior fossa surgery: report of 3 cases

Superficial siderosis of the central nervous system associated with incomplete dural closure following posterior fossa surgery: report of 3 cases

CSF tau protein is a useful marker for effective treatment of superficial siderosis of the central nervous system: Two case reports

Superficial Siderosis of the Central Nervous System

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