SUMMARY Orthostatic transient ischemic attacks (TIA) are very much rarer than orthostatic generalized cerebral ischemia (syncope). A case is described and previous reports reviewed. Orthostatic TIA appears to occur only with large vessel occlusion. In these patients, collateral blood supply is marginal and unable to support normal postural autoregulation. Stroke Vol 15, No 6, 1984 TRANSIENT CEREBRAL ISCHEMIC ATTACKS may be focal or generalized (syncope). The latter are usually caused by a fall in systemic blood pressure, often precipitated by standing. Focal transient ischemic attacks (TIA) however, are rarely associated with hypotensive episodes' 2 and even more rarely are precipitated by standing. A case of orthostatic TIA is presented and previous cases from the literature summarized.Case Report A 66 year-old left-handed female experienced sudden difficulty speaking, described as stuttering and knowing what she wanted to say, but being unable to say it. She then went to bed and awoke normal. One hour after rising, her symptoms returned for several minutes. Throughout the day, her symptoms recurred each time she stood.Hypertension had been noted in her twenties, for which she took hydrochlorothiazide, hydralazine and guanethidine. Atrial fibrillation had been present for several years.Neurological examination on admission revealed a single anomic error among 15 objects and reduced right arm swing. Pulse was 56 per minute and irregular. A pansystolic blowing murmur was heard over the cardiac apex. Blood pressure was 190/90 supine, without postural change. CT brain scan revealed a left internal capsular infarct.On the second hospital day, prazosin 2 mg per day was begun. The next day, while having her standing blood pressure measured, she became aphasic. Spontaneous speech was unintelligible, with stuttering and paraphasias. Repetition and comprehension were impaired and she could not follow written commands. There was no pronator drift and visual fields remained full. Blood pressure fell from 128/72 supine to 110/60 standing. On return to the supine position, the aphasia resolved over several minutes. She was asked to stand From Westmead Neurological Centre, 24 Mons Road,