Superficial Venous Thrombophlebitis as the Initial Manifestation of Hypereosinophilic Syndrome

Terrier, B.; Piette, Anne–Marie; Kérob, Delphine; Cordoliani, F.; Tancrède, E.; Hamidou, Leila; Lebbe, Célèste; Blëtry, O.; Kahn, Jean‐Emmanuel

doi:10.1001/archderm.142.12.1606

Cited by 28 publications

(15 citation statements)

References 38 publications

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“…50 Several case reports have described the occurrence of several varieties of thrombosis in HES, including deep venous thrombosis and cutaneous infarction, 66 superficial venous thrombophlebitis, 67 and thrombotic microangipathy. 68 Ogbogu et al have described in detail the potential for HES to cause intracardiac thrombosis.…”

Section: Disease Pathogenesismentioning

confidence: 99%

Eosinophils and Disease Pathogenesis

Akuthota

Weller

2012

Seminars in Hematology

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Section: Disease Pathogenesismentioning

confidence: 99%

Eosinophils and Disease Pathogenesis

Akuthota

Weller

2012

Seminars in Hematology

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“…The absence of neutrophilic vasculitis and lung or renal abnormalities is not compatible with a diagnosis of polyarteritis nodosa or other systemic vasculitis. Thrombosis is a rare complication of eosinophilic vasculitis, but several case reports describe thrombosis of small and/or large vessels in HES and CSS 3–7 . Deep venous thrombosis or peripheral artery occlusion was not excluded as a cause of the long‐standing leg oedema and digital gangrene in our patient.…”

Section: Reportmentioning

confidence: 70%

“…Terrier et al. 7 speculated that organ damage secondary to eosinophil infiltrate was not always associated with peripheral eosinophilia, due to rapid homing of eosinophils into tissues.…”

Section: Reportmentioning

confidence: 99%

Thrombotic eosinophilic vasculitis

Nakajima

Nakamura²

2009

Clinical and Experimental Dermatology

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Eosinophilic vasculitis is characterized by pruritic erythema, papules and angio-oedema. We report a case of thrombotic eosinophilic vasculitis with leg oedema and widespread purpura, which resulted in extensive gangrene. Corticosteroids and anticoagulants relieved the symptoms; however, deep ulcers remained after the removal of gangrene. An attempt to decrease corticosteroid dose caused a recurrence of purpura. This case strongly suggests that eosinophilis evoke serious cutaneous vasculitis in the absence of hypereosinophilia.

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“…HES with cutaneous necrotizing vasculitis may also cause infarction in various organs as well as other systemic vasculitises, such as polyarteritis nodosa and CSS. Recently, Terrier et al 15 have reported three cases of HES manifested by superficial venous thrombophlebitis. The etiology of cutaneous necrotizing vasculitis in HES is unknown; however, HES may cause thrombosis or infarction in specific organs, and we should take this into consideration as a complication of HES.…”

Section: Discussionmentioning

confidence: 99%

Case of hypereosinophilic syndrome with cutaneous necrotizing vasculitis

Hayashi¹,

Kawaguchi²,

Mitsuhashi³

et al. 2008

The Journal of Dermatology

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A 25-year-old male presented with pruritic papules over his trunk and extremities. The pruritic eruption had appeared on the arms 5 months before and gradually spread over the trunk. Blood tests showed a white blood cell count of 13 760/microL with 42.2% eosinophils. A skin biopsy from the leg revealed necrotizing vasculitis in the upper dermis with prominent eosinophil infiltration in the dermis and subcutis. Liver dysfunction in accordance with eosinophilia was also seen. The underlying disorder causing the eosinophilia was not detected. We diagnosed this case as hypereosinophilic syndrome. Although systemic corticosteroid therapy using prednisolone was effective, the symptoms recurred during a reduction of prednisolone. The addition of cyclosporine resulted in improvement of his symptoms. Both drugs were successfully tapered without relapsing symptoms. Hypereosinophilic syndrome with cutaneous necrotizing vasculitis is a rare condition, and this case suggests that cyclosporine may be a useful therapeutic adjunct in facilitating steroid tapering.

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Superficial Venous Thrombophlebitis as the Initial Manifestation of Hypereosinophilic Syndrome

Cited by 28 publications

References 38 publications

Eosinophils and Disease Pathogenesis

Eosinophils and Disease Pathogenesis

Thrombotic eosinophilic vasculitis

Case of hypereosinophilic syndrome with cutaneous necrotizing vasculitis

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