Superfine wheat bran improves the hyperglycemic and hyperlipidemic properties in a high-fat rat model

Junejo, Shahid Ahmed; Geng, Huihui; Li, Songnan; Kaka, Ajeet Kumar; Rashid, Asif; Zhou, Yibin

doi:10.1007/s10068-019-00684-8

Cited by 7 publications

(8 citation statements)

References 32 publications

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“…These fractions contained bioactive compounds such as phytochemicals, some essential micronutrients, vitamins, and dietary fiber. Many studies have demonstrated an association between CVD and whole grain and bran consumption (Aune et al, 2016 ; Charlton et al, 2012 ; Junejo et al, 2019 ; Zong et al, 2016 ). However, the results for germ are unclear (de Munter et al, 2007 ; Lupton et al, 1994 ).…”

Section: Introductionmentioning

confidence: 99%

Effect of wheat germ on metabolic markers: a systematic review and meta-analysis of randomized controlled trials

Liaqat

Jeong

Kim

et al. 2020

Food Sci Biotechnol

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This systematic review and meta-analysis aim to evaluate the association of wheat germ interventions and metabolic markers. An electronic search was performed by mid-May 2019 in the PubMed, Google Scholar, and Web of Science databases. Quality was evaluated using the risk of bias assessment tools. Thirty-three randomized controlled trials (RCTs) were identified, among which ten were suitable and systematically reviewed based on biomarkers (cholesterol, triglycerides, glucose, and oxidative stress). Three biomarkers in five eligible studies were investigated by meta-analysis. Total cholesterol showed non-significant results (p = 0.98), with standard mean difference (SMD) of-0.01 (95% confidence interval;-0.17, 0.16). The SMD was-0.06 (95% CI-0.41, 0.29, n = 4) for triglycerides and-0.09 (95% CI-0.62, 0.45, n = 2) for glucose. No biomarkers showed heterogeneity (0%). This review revealed non-significant association between wheat germ interventions and metabolic markers. Sensitive analysis with high-quality RCTs may be worth trying.

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Section: Introductionmentioning

confidence: 99%

Effect of wheat germ on metabolic markers: a systematic review and meta-analysis of randomized controlled trials

Liaqat

Jeong

Kim

et al. 2020

Food Sci Biotechnol

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“…This may be due to the solubility of the fiber, making it more accessible to be fermented by the gut microbiota, or it may be due to other factors such as viscosity or the substrates these fibers are broken down into during fermentation [125]. In human trials, β-glucan, wheat dextrin, and inulin-type fructans have repeatedly resulted in improved body composition and parameters of glucose homeostasis in obese, diabetic, and healthy individuals [21,47,51,55,62,65,66,72,100,102,111]. However, studies examining the metabolic improvements following high-amylose maize, pectin, or soluble corn fiber supplementation are not as conclusive [22,33,37,43].…”

Section: Discussionmentioning

confidence: 99%

“…In rodents, wheat bran supplementation (0.8-5%) attenuates HFD-induced weight gain and decreases adiposity [62,63], while in humans, acute supplementation of 41 g wheat bran decreased subsequent energy intake (p = 0.02) [64]. Wheat bran supplementation has also been associated with improvements in glucose homeostasis, as evidenced by decreased serum glucose and HOMA-IR in rodent models [62,[65][66][67]. Additionally, wheat bran supplementation is associated with other positive health benefits such as decreased serum lipids and free fatty acids and improved HDL in rodents [62,65,67].…”

Section: Wheat Fibermentioning

confidence: 99%

“…Wheat bran supplementation has also been associated with improvements in glucose homeostasis, as evidenced by decreased serum glucose and HOMA-IR in rodent models [62,[65][66][67]. Additionally, wheat bran supplementation is associated with other positive health benefits such as decreased serum lipids and free fatty acids and improved HDL in rodents [62,65,67]. Interestingly, despite decreased body weight in rodents following wheat bran supplementation, no studies observed a significant decrease in food intake, with one study actually displaying an increase in food intake with as low as 0.8% dietary wheat bran supplementation in HFD for 24 weeks [62].…”

Section: Wheat Fibermentioning

confidence: 99%

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Therapeutic Potential of Various Plant-Based Fibers to Improve Energy Homeostasis via the Gut Microbiota

2021

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Obesity is due in part to increased consumption of a Western diet that is low in dietary fiber. Conversely, an increase in fiber supplementation to a diet can have various beneficial effects on metabolic homeostasis including weight loss and reduced adiposity. Fibers are extremely diverse in source and composition, such as high-amylose maize, β-glucan, wheat fiber, pectin, inulin-type fructans, and soluble corn fiber. Despite the heterogeneity of dietary fiber, most have been shown to play a role in alleviating obesity-related health issues, mainly by targeting and utilizing the properties of the gut microbiome. Reductions in body weight, adiposity, food intake, and markers of inflammation have all been reported with the consumption of various fibers, making them a promising treatment option for the obesity epidemic. This review will highlight the current findings on different plant-based fibers as a therapeutic dietary supplement to improve energy homeostasis via mechanisms of gut microbiota.

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“…Autophagy is a cellular metabolic mechanism, which transports intracellular substances to lysosomes for degradation and promotes the synthesis of new substances. Autophagy disorder occurs in the pathogenesis of many diseases, including inflammation, neurodegenerative diseases, and cancer (Junejo et al, 2020). Autophagy leads to slow wave rhythm and abnormal excitation conduction in gastrointestinal tract, which is the key mechanism of many gastrointestinal diseases including STC.…”

Section: Introductionmentioning

confidence: 99%

Effect of miR-129-3p on autophagy of interstitial cells of Cajal in slow transit constipation through SCF C-kit signaling pathway

et al. 2022

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Objective: To explore the mechanism by which miR-129-3p affected the autophagy of interstitial cells of Cajal (ICCs) in slow transit constipation tissues through the SCF C-kit signaling pathway. Methods: Colon samples from 20 Slow transit constipation (STC) patients who underwent total colectomy plus ileorectal anastomosis or subtotal colon resection plus anti-peristaltic rectal anastomosis were collected in our hospital. The colon of 20 non-STC patients was used as control. The control of this study was 20 patients undergoing radical surgery for colon cancer (left colon cancer) in our hospital. Fifty healthy SPF Kunming mice were purchased from Liaoning Changsheng Biotechnology Co., Ltd. Results: The mRNA expression of miR-129-3p in the STC group was lower than that in the control group (CTLR) group (P<0.05). The mRNA expression of miR-129-3p in STC group was lower than that in the NC group (P<0.05), and mRNA expression in STC+miR-129-3p group was higher than that in STC+miR-NC group (P<0.05). In the first week, the weight of dry and wet feces of the STC group was lower than that of the NC mice (P<0.05), and the weight of dry feces and wet feces of the STC group was lower than that of the NC group at the 2, 3, and 4 weeks, STC+miR-129 -3p was higher than that in the STC group (P<0.05). Conclusion: The increased expression of C-kit and SCF regulated by miR-129-3p contributed to the protection of interstitial cells. Knockdown of miR-129-3p expression could inhibit the activation of AKT/mTOR signaling pathway, reduce cell proliferation activity.

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Superfine wheat bran improves the hyperglycemic and hyperlipidemic properties in a high-fat rat model

Cited by 7 publications

References 32 publications

Effect of wheat germ on metabolic markers: a systematic review and meta-analysis of randomized controlled trials

Effect of wheat germ on metabolic markers: a systematic review and meta-analysis of randomized controlled trials

Therapeutic Potential of Various Plant-Based Fibers to Improve Energy Homeostasis via the Gut Microbiota

Effect of miR-129-3p on autophagy of interstitial cells of Cajal in slow transit constipation through SCF C-kit signaling pathway

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