Superhemophobic titania nanotube array surfaces for blood contacting medical devices

Bartlet, Kevin; Movafaghi, Sanli; Kota, Arun K.; Popat, Ketul C.

doi:10.1039/c7ra03373g

Cited by 34 publications

(28 citation statements)

References 39 publications

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“…The results are consistent with previously published XPS spectra for Ti, NT and NT-S1 since they were fabricated in similar way. [31] The presence of these peaks confirms that the titania nanotube arrays were successfully modified by silanes.…”

Section: Resultsmentioning

confidence: 79%

“…The crystal phases for the nanotube arrays differ from titanium, indicating that the fabrication process changed the underlying crystal structures of the titania nanotube arrays. [31,32] The phases do not differ between the different nanotube arrays, however, indicating that the silanization process does not affect the underlying crystal structure. [31,32] These results are also consistent with previously published XRD spectra for titania nanotube arrays.…”

Section: Resultsmentioning

confidence: 99%

“…[31,32] The phases do not differ between the different nanotube arrays, however, indicating that the silanization process does not affect the underlying crystal structure. [31,32] These results are also consistent with previously published XRD spectra for titania nanotube arrays. [31]…”

Section: Resultsmentioning

confidence: 99%

“…The scans were collected over a 2θ range of 20° to 80° with θ=1.5°. [31] They were run at a rate of 1 step per sec with a step size of 0.01°. DIFFRACT.EVA was used to filter the data and identify the relevant peaks.…”

Section: Methodsmentioning

confidence: 99%

“…[5,9,18,27–30] Further, superhydrophobic surfaces exhibit reduced protein adsorption and any proteins that do adhere are easy to remove. [11,31] These properties are expected to make it more difficult for bacteria to attach and form biofilms on superhydrophobic surfaces.…”

Section: Introductionmentioning

confidence: 99%

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Antibacterial activity on superhydrophobic titania nanotube arrays

Bartlet

Movafaghi

Dasi

et al. 2018

Colloids and Surfaces B: Biointerfaces

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Bacterial infections are a serious issue for many implanted medical devices. Infections occur when bacteria colonize the surface of an implant and form a biofilm, a barrier which protects the bacterial colony from antibiotic treatments. Further, the anti-bacterial treatments must also be tailored to the specific bacteria that is causing the infection. The inherent protection of bacteria in the biofilm, differences in bacteria species (gram-positive vs. gram-negative), and the rise of antibiotic-resistant strains of bacteria makes device-acquired infections difficult to treat. Recent research has focused on reducing biofilm formation on medical devices by modifying implant surfaces. Proposed methods have included antibacterial surface coatings, release of antibacterial drugs from surfaces, and materials which promote the adhesion of non-pathogenic bacteria. However, no approach has proven successful in repelling both gram-positive and gram-negative bacteria. In this study, we have evaluated the ability of superhydrophobic surfaces to reduce bacteria adhesion regardless of whether the bacteria are gram-positive or gram-negative. Although superhydrophobic surfaces did not repel bacteria completely, they had minimal bacteria attached after 24 h and more importantly no biofilm formation was observed.

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Section: Resultsmentioning

confidence: 79%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Antibacterial activity on superhydrophobic titania nanotube arrays

Bartlet

Movafaghi

Dasi

et al. 2018

Colloids and Surfaces B: Biointerfaces

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Interaction of Blood and Bacteria with Slippery Hydrophilic Surfaces

Kantam,

Manivasagam,

Jammu

et al. 2023

Adv Materials Inter

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Slippery surfaces (i.e., surfaces that display high liquid droplet mobility) are receiving significant attention due to their biofluidic applications. Non‐textured, all‐solid, slippery hydrophilic (SLIC) surfaces are an emerging class of rare and counter‐intuitive surfaces. In this work, the interactions of blood and bacteria with SLIC surfaces are investigated. The SLIC surfaces demonstrate significantly lower platelet and leukocyte adhesion (≈97.2% decrease in surface coverage), and correspondingly low platelet activation, as well as significantly lower bacterial adhesion (≈99.7% decrease in surface coverage of live Escherichia Coli and ≈99.6% decrease in surface coverage of live Staphylococcus Aureus) and proliferation compared to untreated silicon substrates, indicating their potential for practical biomedical applications. The study envisions that the SLIC surfaces will pave the path to improved biomedical devices with favorable blood and bacteria interactions.

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Influence of electrical polarization on thrombogenicity of titania nanotubes

Muralidhar,

Sakthivel,

Sridharan

et al. 2024

Int J Ceramic Engine & Sci

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The development of hemocompatible biomaterials with antithrombogenic surface coatings remains a challenge in cardiovascular applications. There is interest in negatively charged surfaces that inhibit thrombus formation through electrostatic repulsion between the biomaterial surface and negatively charged platelets. Hence, the present study investigated the influence of electrical polarization on the thrombogenicity of titania nanotubes (TNT), which are promising candidates for inhibiting thrombogenicity via surface modification. TNTs were formed on commercially pure titanium plate by the electrochemical anodization technique using platinum as a counter electrode at 60 V for 24 h with two kinds of electrolytes (hydrofluoric acid diluted with dimethyl sulfoxide [D‐TNT] or ethylene glycol [E‐TNT]) followed by an annealing at 540°C for 3 h in air. Both TNTs were mixture of anatase and rutile, and the D‐TNT had a diameter of 108.76 ± 2.55 nm and the E‐TNT, 53.833 ± 2.42 nm. The TNTs were electrically polarized at 100 V of DC field and 400°C for 1 h. Water contact angle measurements showed that the non‐polarized (0‐) TNT surface was hydrophilic whereas the positively (P‐) or negatively (N‐) polarized TNT surfaces showed high‐hydrophilicity. Antithrombogenicity was evaluated using the thrombus coverage area ratio (TCAR) after soaking the TNTs in bovine whole blood. The TCARs for 0‐polarized E‐ and D‐TNTs were 5.30 ± 4.34% and 36.3 ± 5.8% and for P‐polarized E‐TNT and D‐TNT were 1.50 ± 0.77% and 2.76 ± 1.07%, whereas no thrombus formation (0 ± 0%) for N‐polarized E‐TNT and very few thrombus formation (0.12 ± 0.22%) for N‐polarized D‐TNT. The electrostatic repulsion between the N‐polarized E‐TNTs and platelets completely inhibits thrombus formation, which cannot be achieved by the nanomorphology and high‐hydrophilicity of other TNTs. Hence, N‐TNTs formed by electrical polarization are potential candidates for cardiovascular devices, such as artificial heart valves with long‐term hemocompatibility.

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Superhemophobic titania nanotube array surfaces for blood contacting medical devices

Abstract: Appropriate hemocompatible response for blood-contacting medical devices is necessary to prevent device failure.

Cited by 34 publications

References 39 publications

Antibacterial activity on superhydrophobic titania nanotube arrays

Antibacterial activity on superhydrophobic titania nanotube arrays

Interaction of Blood and Bacteria with Slippery Hydrophilic Surfaces

Influence of electrical polarization on thrombogenicity of titania nanotubes

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