Superhigh‐Throughput Needleless Electrospinning Using a Rotary Cone as Spinneret

Lu, Bingan; Wang, Yan‐Jiang; Liu, Yanxia; Duan, Huigao; Zhou, Jinyuan; Zhang, Zhenxing; Wang, Youqing; Li, Xiaodong; Wang, Wei; Lan, Wei; Xie, Erqing

doi:10.1002/smll.201000454

Cited by 201 publications

(132 citation statements)

References 31 publications

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“…57,58 The positioning of sucralose in the sheath component would effectively provide an acceptable taste for patients if solid dispersions are developed further as oral drug delivery systems. On the other hand, researchers are now focusing on the mass preparation of nanofibers for scaling up, 59,60 so the development of core-sheath solid dispersions as demonstrated here may offer a solution for development of commercial products that involve poorly water-soluble active ingredients.…”

mentioning

confidence: 99%

Solid dispersions in the form of electrospun core-sheath nanofibers

Yu¹,

Zhu²,

Branford-White³

et al. 2011

IJN

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Background:The objective of this investigation was to develop a new type of solid dispersion in the form of core-sheath nanofibers using coaxial electrospinning for poorly water-soluble drugs. Different functional ingredients can be placed in various parts of core-sheath nanofibers to improve synergistically the dissolution and permeation properties of encapsulated drugs and to enable drugs to exert their actions. Methods: Using acyclovir as a model drug, polyvinylpyrrolidone as the hydrophilic filamentforming polymer matrix, sodium dodecyl sulfate as a transmembrane enhancer, and sucralose as a sweetener, core-sheath nanofibers were successfully prepared, with the sheath part consisting of polyvinylpyrrolidone, sodium dodecyl sulfate, and sucralose, and the core part composed of polyvinylpyrrolidone and acyclovir. Results: The core-sheath nanofibers had an average diameter of 410 ± 94 nm with a uniform structure and smooth surface. Differential scanning calorimetry and x-ray diffraction results demonstrated that acyclovir, sodium dodecyl sulfate, and sucralose were well distributed in the polyvinylpyrrolidone matrix in an amorphous state due to favoring of second-order interactions. In vitro dissolution and permeation studies showed that the core-sheath nanofiber solid dispersions could rapidly release acyclovir within one minute, with an over six-fold increased permeation rate across the sublingual mucosa compared with that of crude acyclovir particles. Conclusion: The study reported here provides an example of the systematic design, preparation, characterization, and application of a novel type of solid dispersion consisting of multiple components and structural characteristics.

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mentioning

confidence: 99%

Solid dispersions in the form of electrospun core-sheath nanofibers

Yu¹,

Zhu²,

Branford-White³

et al. 2011

IJN

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“…All these needleless electrospinning methods can be divided primarily into two groups: rotary and stationary spinneret needleless electrospinning [3]. Rotary needleless electrospinning includes rotary cylinder, disc, ball, spiral wire coil, splashing spinneret, cone, edge of metal plate, rotating roller, bowel edge, rotary beaded chain [4][5][6][7][8][9], and so on. In stationary spinneret needleless electrospinning, the use of vertical rod [10], air bubble [11], conical wire coil [12], and metallic tube electrode [13] has been reported.…”

Section: Introductionmentioning

confidence: 99%

Needleless Electrospinning and Electrospraying of Mixture of Polymer and Aerogel Particles on Textile

Shaid

Wang

Padhye

et al. 2018

Advances in Materials Science and Engineering

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Needleless electrospinning and electrospraying of aerogel particles in comparatively lower electric voltage (9 kV) have been demonstrated in the paper. Aerogel particles were dispersed in polymer solution and then needlelessly electrospun/sprayed by creating high electric charge at the syringe tip using a curved wire. FTIR spectra and SEM images proved that aerogel particles were deposited onto the base textile. In case of electrospinning, a nanofibre web holding the aerogel particles covered the fabric surface, whereas in case of electrospraying, aerogel particles deposited with the microdroplets of the polymer. e electrospraying process showed great potential for fabric surface functionalization due to the high amount of particle deposition on fabric. e new approach can be applicable for transferring other particulate materials on fabric surface through needleless electrospinning and electrospraying processes.

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“…The raw polymer material can be electrospun to form fine fibers. 23,24 Electrospun PVP fibers have been applied for drug delivery 25,26 and as membranes in batteries, 27 however have received less attention for application in filter media. In this work, PVP fiber mats of different average diameters were electrospun from solutions of different polymer concentrations.…”

Section: Introductionmentioning

confidence: 99%

Solid Aerosol Filtration by Electrospun Poly Vinyl Pyrrolidone Fiber Mats and Dependence on Pore Size

Zhang¹

2017

JTEFT

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The pore openings of electrospun fiber mats can vary significantly with fiber diameter and with basis weight for low basis weight mats. To evaluate the effects of fiber diameter and basis weight on filter performance, poly vinyl Pyrrolidone fibers of three average diameters (287, 883, and 1709nm) were electrospun to form nonwoven fiber mats of six basis weights (5, 10, 15, 22.5, 30, and 45g/m 2 ). The fiber mats were tested for capillary flow porometry and solid aerosol capture. The bubble point pore diameter (largest pore) and the mean-flow pore diameter (average pore diameter based on flow measurement) decreased as the basis weight increased and approached minimum plateaus at 30g/m 2 basis weight and larger. The mats with larger fibers tended to have larger pores. The minimum plateau bubble point diameters were approximately 1.5~2 times the size as the average fiber diameter. The fiber mats with an average fiber diameter of 287nm and basis weight of 45g/m 2 yielded the best separation efficiency (99.89%) in capture of NaCl nano particles of diameters ranging from 25 to 100nm.Keywords: poly vinyl pyrrolidone, electro spinning, capillary flow porometry, aerosol, particle capture, filtration, aerosol filtration, electro spun, pore size, gas pressure, nanometers, filter thickness, fine fibers, porosity, polymer concentrations, capillary flow porometer Journal of Textile Engineering & Fashion Technology Short Communication Open AccessSolid aerosol filtration by electrospun poly vinyl pyrrolidone fiber mats and dependence on pore size media. In this work, PVP fiber mats of different average diameters were electrospun from solutions of different polymer concentrations. For each diameter range, fiber mats of different basis weights were produced. It is well known that filter media thickness affects filter performance. Whereas electrospun fiber mats tend to be very thin and their thicknesses are difficult to measure accurately. For the thin fiber mats the basis weight (mass per mat area) is a more robust and convenient measure for comparison of filter media performances.The objective of this work was to evaluate filter performance and the corresponding structure changes in the mat as a function of the basis weight. Filter performance depends upon many parameters including porosity, pore size, fiber size, and filter thickness. From common experience, the pore openings of an electrospun fiber mat are known to vary significantly with the fiber size and with the basis weight for low basis weight fiber mats. As the basis weight increases, the pores within the fiber mat gradually approach a minimum plateau. To evaluate the variations of basis weight and pore size on filter performance, PVP fiber mats were electrospun with six basis weights ranging from 5 to 45g/m 2 and with three average fiber diameters from 287 to 1709nm. The PVP fiber mats pore size distributions, bubble point pore size, and mean-flow pore diameter, were measured. The electrospun fiber mats were tested as filter media to separate dispersed NaCl ...

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Superhigh‐Throughput Needleless Electrospinning Using a Rotary Cone as Spinneret

Cited by 201 publications

References 31 publications

Solid dispersions in the form of electrospun core-sheath nanofibers

Solid dispersions in the form of electrospun core-sheath nanofibers

Needleless Electrospinning and Electrospraying of Mixture of Polymer and Aerogel Particles on Textile

Solid Aerosol Filtration by Electrospun Poly Vinyl Pyrrolidone Fiber Mats and Dependence on Pore Size

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