Superhydrophilic nanocomposite adsorbents modified via nitrogen-rich phosphonate-functionalized ionic liquid linkers: enhanced phosphopeptide enrichment and phosphoproteome analysis of tau phosphorylation in the hippocampal lysate of Alzheimer's transgenic mice

Abstract

In this study, new graphene-based IMAC nanocomposites for phosphopeptide enrichment were prepared under the guideline of our new design strategy. Superhydrophilic polyethyleneimine (PEI) was introduced, to which phosphonate-functionalized ionic liquid...