Superhydrophobic modification fails to improve the performance of small diameter expanded polytetrafluoroethylene vascular grafts

Toes, GJ; Muiswinkel, K.W van; Oeveren, Wim van; Suurmeijer, Albert; Timens, Wim; Stokroos, I.; Dungen, J.J.A.M. van den

doi:10.1016/s0142-9612(01)00103-x

Cited by 52 publications

(37 citation statements)

References 9 publications

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“…9). Note that surface wettability has been widely recognized as one of the important factors influencing platelet response 28–34. We found good correlation between WCAs and platelet response for different substrates as shown in Figure 9, which reveals WCA dependence of the platelet behavior on groove‐ and pillar‐patterned surfaces: the levels of platelet adhesion and activation decrease with WCAs.…”

Section: Discussionsupporting

confidence: 58%

Effects of microtopographic patterns on platelet adhesion and activation on titanium oxide surfaces

Ding¹,

Leng²,

Huang³

et al. 2012

J Biomedical Materials Res

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This study systematically investigated the effects of microtopographic patterns of titanium oxide on platelet adhesion and activation in order to reveal the mechanisms of interactions between platelet and surface topography. Periodic arrays of groove and pillar patterns with dimensions ranging from submicron to several micrometers were fabricated by photolithography and deep reactive-ion etching on silicon substrates, followed by the sputter deposition of titanium oxide (TiO(2)). Platelet adhesion and activation on TiO(2) patterned surfaces were evaluated by lactate dehydrogenase (LDH) and GMP-140 assays, respectively. The morphology of adherent platelets was examined by scanning electron microscope (SEM). The results showed that the microtopographic patterns were able to effectively manipulate the platelet response by varying geometry and size of patterns. A groove pattern resulted in much higher levels of platelet adhesion and activation than a pillar pattern. The study revealed that a difference in pattern size led to two distinctive modes of platelet adhesion: the "bridging" mode in which platelets can bridge over spacing between adjacent patterns when spacing size is smaller than 1.5 μm; and the "full-contact" mode in which platelets cannot bridge but fully contact the entire surface when spacing size is larger than 3 μm. Our analysis indicates good correlations between platelet behavior and hydrophobicity/wetting anisotropy in "bridging" mode, and effective surface contact area in "full-contact" mode.

show abstract

Section: Discussionsupporting

confidence: 58%

Effects of microtopographic patterns on platelet adhesion and activation on titanium oxide surfaces

Ding¹,

Leng²,

Huang³

et al. 2012

J Biomedical Materials Res

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show abstract

“…Superhydrophobic surfaces are being explored for their potential use in increasing blood compatibility, where the gaseous interface provides a unique approach to prevent material-blood interactions. Toes et al [155] studied commercial expanded polytetrafluoroethylene (ePTFE) and superhydrophobic ePTFE (modified commercial ePTFE using ion beam etching) as vascular grafts in mice to determine if superhydrophobicity led to improved performance. Early effects of the ePTFE and superhydrophobic ePTFE were studied by examining platelet glycoprotein IIIa, a receptor which mediates thrombus formation, after 15 minutes of contact with human blood in a circulation setup.…”

Section: Blood Compatibilitymentioning

confidence: 99%

“…No thrombus formation was observed. As shown by α -actin staining, the majority of neointima formation in (c) ePTFE and (d) superhydrophobic PTFE is smooth muscle, reprinted with permission from [155]. …”

Section: Figurementioning

confidence: 99%

Superhydrophobic materials for biomedical applications

et al. 2016

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Superhydrophobic surfaces are actively studied across a wide range of applications and industries, and are now finding increased use in the biomedical arena as substrates to control protein adsorption, cellular interaction, and bacterial growth, as well as platforms for drug delivery devices and for diagnostic tools. The commonality in the design of these materials is to create a stable or metastable air state at the material surface, which lends itself to a number of unique properties. These activities are catalyzing the development of new materials, applications, and fabrication techniques, as well as collaborations across material science, chemistry, engineering, and medicine given the interdisciplinary nature of this work. The review begins with a discussion of superhydrophobicity, and then explores biomedical applications that are utilizing superhydrophobicity in depth including material selection characteristics, in vitro performance, and in vivo performance. General trends are offered for each application in addition to discussion of conflicting data in the literature, and the review concludes with the authors’ future perspectives on the utility of superhydrophobic surfaces for biomedical applications.

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“…A recent publication highlights the possibilities of superhydrophobic coatings but also shows how little work has been undertaken in this area. 16 Proteins dissolved in water do adhere to superhydrophobic surfaces 17 , although often less rapidly than on flat surfaces 17,18 . The reduction in rate may be due to a requirement for conformational changes prior to adsorption or the hydrophilicity of an adsorbed protein layer driving the solvent front into the surface structure allowing water and protein to penetrate.…”

Section: Introductionmentioning

confidence: 99%

Nano-scale superhydrophobicity: suppression of protein adsorption and promotion of flow-induced detachment

et al. 2008

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Superhydrophobic modification fails to improve the performance of small diameter expanded polytetrafluoroethylene vascular grafts

Cited by 52 publications

References 9 publications

Effects of microtopographic patterns on platelet adhesion and activation on titanium oxide surfaces

Effects of microtopographic patterns on platelet adhesion and activation on titanium oxide surfaces

Superhydrophobic materials for biomedical applications

Nano-scale superhydrophobicity: suppression of protein adsorption and promotion of flow-induced detachment

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