Superimposed dual-isotope SPECT using99mTc-hydroxymethylene diphosphonate and201Tl-chloride to assess cartilage invasion in laryngohypopharyngeal cancer
Abstract:Results of the present study suggest that superimposed early bone and tumor dual-isotope SPECT images may be sufficient for the diagnostic evaluation of cartilage invasion by laryngohypopharyngeal cancer. Superimposed dual-isotope SPECT imaging is a useful technique in the evaluation of cartilage invasion in laryngohypopharyngeal cancer.
“…The accuracy of both techniques is approximately 80% and this compares favourably with combined clinical and endoscopic examination which has a staging accuracy of 58% [19] . Additional imaging modalities such as dual isotope SPECT [22] imaging and ultrasound [6] have been evaluated but there is limited available data. Figure 7Erosion of the thyroid cartilage (a) and cricoid cartilage (b) indicates cartilage involvement by tumour.…”
The radiologist makes a valuable contribution to the staging of laryngeal cancer and this has a direct influence on treatment planning. This review focuses on the main anatomical concepts, patterns of tumour spread and how to detect this with optimal cross sectional imaging. Issues surrounding the relationship of tumour to the ventricular complex, submucosal laryngeal spaces, anteroposterior extension, laryngeal cartilage involvement and metastatic spread are discussed and illustrated. The impact of these imaging findings on the array of therapeutic options is described.
“…The accuracy of both techniques is approximately 80% and this compares favourably with combined clinical and endoscopic examination which has a staging accuracy of 58% [19] . Additional imaging modalities such as dual isotope SPECT [22] imaging and ultrasound [6] have been evaluated but there is limited available data. Figure 7Erosion of the thyroid cartilage (a) and cricoid cartilage (b) indicates cartilage involvement by tumour.…”
The radiologist makes a valuable contribution to the staging of laryngeal cancer and this has a direct influence on treatment planning. This review focuses on the main anatomical concepts, patterns of tumour spread and how to detect this with optimal cross sectional imaging. Issues surrounding the relationship of tumour to the ventricular complex, submucosal laryngeal spaces, anteroposterior extension, laryngeal cartilage involvement and metastatic spread are discussed and illustrated. The impact of these imaging findings on the array of therapeutic options is described.
“…Novi Sad: novembar-decembar, I na polju radioloskih metoda ispitivanja larinksa dostaje radeno. Dok CT ima kljucnu ulogu u pre-operacijskorn odredivanju stadijuma bolesti kod karcinoma larinksa, PET se koristi zaneprepoznate primarne lezije i sekundarne primarne tumore, za odredivanje stadijuma bolesti pre terapije iIi detekciju rezidualne i/ili recidvantne bolesti, procenu odgovora na primenjenu terapiju i detekciju distalnih metastaza [46]. Ove radioloske dijagnosticke metode ornogucavaju da se precizno odredi sirenje primarnog tumora, zahvatanje (invazija) kosti iii hrskavice, a posebno tacno odredi regionalno (nodalno) sirenje bolesti.…”
The progress in the elucidation of the molecular genetic changes in these tumors should soon bring novel diagnostic procedures into the clinical practise. The review higlights the important advances of endoscopic, radilogical and molecular methods in detection of the tumor which may help clinicians to diagnose tumors as early as possible. TNM staging, biopsy and histopathological grading remain the gold standard for diagnosis of laryngeal carcinoma. A great number of novel endoscopical methods are only supplementary tools to microlaryngoscopy. Some of the most significant biological markers might be integrated with the evaluation of behavioural factors, clinical and histopathological examinations for a new clinicomolecular approach to laryngeal cancer.
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