Superior Bioavailability of a Novel Curcumin Formulation in Healthy Humans Under Fasting Conditions

Kothaplly, Sudhakar; Alukapally, Shankar; Nagula, Nagaraju; Maddela, Rambabu

doi:10.1007/s12325-022-02081-w

Cited by 19 publications

(14 citation statements)

References 34 publications

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“…In another study, curcuRouge was demonstrated to reduce the neutrophil to lymphocyte ratio without any safety issues in healthy subjects . Another formulation Curcuwin Ultra+ showed enhanced bioavailability and was found to be safe in healthy subjects . Another next-generation formulation with superior bioavailability, Longvida was also elucidated to reduce fatigue, and oxidative stress, tension, and anxiety, and improved mood-related issues, and cognitive functions in healthy individuals with excellent safety and no side effects. − Moreover, clinical trials on obese patients have revealed that Longvida intake improved cerebral artery stiffness, cerebrovascular responsiveness, and lipid profile without side effects. − It has also been shown to be beneficial in treating both OSF and osteoarthritis. , Another illuminating clinical trial evidenced the use of Longvida in detecting amyloid spots in the retina of Alzheimer’s patients and reported that this formulation exhibits a greater capacity to identify these spots in positron emission tomography (PET) scanning compared to conventional amyloid PET in longitudinal evaluation of amyloid risk and neurodegeneration (LEARN) study …”

Section: Curcumin Formulationsmentioning

confidence: 99%

“… 303 Another formulation Curcuwin Ultra+ showed enhanced bioavailability and was found to be safe in healthy subjects. 304 Another next-generation formulation with superior bioavailability, Longvida was also elucidated to reduce fatigue, and oxidative stress, tension, and anxiety, and improved mood-related issues, and cognitive functions in healthy individuals with excellent safety and no side effects. 305 − 308 Moreover, clinical trials on obese patients have revealed that Longvida intake improved cerebral artery stiffness, cerebrovascular responsiveness, and lipid profile without side effects.…”

Section: Curcumin Formulationsmentioning

confidence: 99%

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Curcumin Formulations for Better Bioavailability: What We Learned from Clinical Trials Thus Far?

et al. 2023

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Curcumin has been credited with a wide spectrum of pharmacological properties for the prevention and treatment of several chronic diseases such as arthritis, autoimmune diseases, cancer, cardiovascular diseases, diabetes, hemoglobinopathies, hypertension, infectious diseases, inflammation, metabolic syndrome, neurological diseases, obesity, and skin diseases. However, due to its weak solubility and bioavailability, it has limited potential as an oral medication. Numerous factors including low water solubility, poor intestinal permeability, instability at alkaline pH, and fast metabolism contribute to curcumin’s limited oral bioavailability. In order to improve its oral bioavailability, different formulation techniques such as coadministration with piperine, incorporation into micelles, micro/nanoemulsions, nanoparticles, liposomes, solid dispersions, spray drying, and noncovalent complex formation with galactomannosides have been investigated with in vitro cell culture models, in vivo animal models, and humans. In the current study, we extensively reviewed clinical trials on various generations of curcumin formulations and their safety and efficacy in the treatment of many diseases. We also summarized the dose, duration, and mechanism of action of these formulations. We have also critically reviewed the advantages and limitations of each of these formulations compared to various placebo and/or available standard care therapies for these ailments. The highlighted integrative concept embodied in the development of next-generation formulations helps to minimize bioavailability and safety issues with least or no adverse side effects and the provisional new dimensions presented in this direction may add value in the prevention and cure of complex chronic diseases.

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Section: Curcumin Formulationsmentioning

confidence: 99%

Section: Curcumin Formulationsmentioning

confidence: 99%

Curcumin Formulations for Better Bioavailability: What We Learned from Clinical Trials Thus Far?

et al. 2023

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“…In fertile women with regular menstrual cycles, encapsulated curcumin reduced the endometrial expression of VEGF ( p < 0.05) and enhanced COX-2 expression ( p > 0.05) compared to the placebo group . Kothapally et al showed that a novel curcumin formulation (curcumin ultra+) possessed enhanced bioavailability and reduced safety issues at 250 and 500 mg doses (single) compared to 1000 mg turmeric extract in healthy volunteers under fasting conditions . Loriczova et al demonstrated that iron (18 mg and 65 mg) supplementation along with curcumin (500 mg) reduces iron-induced systemic inflammation by reducing plasma levels of TNF-α and thiobarbituric acid-reactive substances in healthy individuals compared to those who received a placebo .…”

Section: Clinical Trials Of Turmeric and Curcuminmentioning

confidence: 99%

Role of Turmeric and Curcumin in Prevention and Treatment of Chronic Diseases: Lessons Learned from Clinical Trials

Kunnumakkara

Hegde

Dey

et al. 2023

ACS Pharmacol. Transl. Sci.

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Turmeric (Curcuma longa) has been used for thousands of years for the prevention and treatment of various chronic diseases. Curcumin is just one of >200 ingredients in turmeric. Almost 7000 scientific papers on turmeric and almost 20,000 on curcumin have been published in PubMed. Scientific reports based on cell culture or animal studies are often not reproducible in humans. Therefore, human clinical trials are the best indicators for the prevention and treatment of a disease using a given agent/drug. Herein, we conducted an extensive literature survey on PubMed and Scopus following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The keywords "turmeric and clinical trials" and "curcumin and clinical trials" were considered for data mining. A total of 148 references were found to be relevant for the key term "turmeric and clinical trials", of which 70 were common in both PubMed and Scopus, 44 were unique to PubMed, and 34 were unique to Scopus. Similarly, for the search term "curcumin and clinical trials", 440 references were found to be relevant, of which 70 were unique to PubMed, 110 were unique to Scopus, and 260 were common to both databases. These studies show that the golden spice has enormous health and medicinal benefits for humans. This Review will extract and summarize the lessons learned about turmeric and curcumin in the prevention and treatment of chronic diseases based on clinical trials.

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“…Furthermore, Curcuwin Ultra+ (CU+), a novel formulation designed to protect curcuminoids from intestinal degradation, demonstrated a significant higher total systemic exposure and C max for total curcuminoids compared with 95% turmeric extract (TUR 1800). Besides CU+ was 40% faster absorbed, it possesses superior bioavailability even at lower concentrations (250 and 500 mg) in comparison with higher doses of TUR 1800 (1900 mg) in healthy volunteers under fasting conditions [ 30 ]. The water-dispersible turmeric extract containing 60% curcuminoids (TurmXtra 60N), referred to as WDTE60N, using a concentration of 150 mg of curcuminoids, demonstrated a higher absorption and exposure for free curcumin, total curcumin, and total curcuminoids at 10-fold lower dose than standard turmeric extract 95% (STE95) (1500 mg) [ 31 ].…”

Section: Curcuminmentioning

confidence: 99%

Phytochemicals in Skeletal Muscle Health: Effects of Curcumin (from Curcuma longa Linn) and Sulforaphane (from Brassicaceae) on Muscle Function, Recovery and Therapy of Muscle Atrophy

Vargas-Mendoza

Madrigal-Santillán

Álvarez-González

et al. 2022

Plants

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The mobility of the human body depends on, among other things, muscle health, which can be affected by several situations, such as aging, increased oxidative stress, malnutrition, cancer, and the lack or excess of physical exercise, among others. Genetic, metabolic, hormonal, and nutritional factors are intricately involved in maintaining the balance that allows proper muscle function and fiber recovery; therefore, the breakdown of the balance among these elements can trigger muscle atrophy. The study from the nutrigenomic perspective of nutritional factors has drawn wide attention recently; one of these is the use of certain compounds derived from foods and plants known as phytochemicals, to which various biological activities have been described and attributed in terms of benefiting health in many respects. This work addresses the effect that the phytochemicals curcumin from Curcuma longa Linn and sulforaphane from Brassicaceae species have shown to exert on muscle function, recovery, and the prevention of muscle atrophy, and describes the impact on muscle health in general. In the same manner, there are future perspectives in research on novel compounds as potential agents in the prevention or treatment of medical conditions that affect muscle health.

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Superior Bioavailability of a Novel Curcumin Formulation in Healthy Humans Under Fasting Conditions

Cited by 19 publications

References 34 publications

Curcumin Formulations for Better Bioavailability: What We Learned from Clinical Trials Thus Far?

Curcumin Formulations for Better Bioavailability: What We Learned from Clinical Trials Thus Far?

Role of Turmeric and Curcumin in Prevention and Treatment of Chronic Diseases: Lessons Learned from Clinical Trials

Phytochemicals in Skeletal Muscle Health: Effects of Curcumin (from Curcuma longa Linn) and Sulforaphane (from Brassicaceae) on Muscle Function, Recovery and Therapy of Muscle Atrophy

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