Superior Canal Dehiscence

Hirvonen, Timo; Carey, John P.; Liang, Cindy; Minor, Lloyd B.

doi:10.1001/archotol.127.11.1331

Cited by 67 publications

(15 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Experimental evidence reported previously demonstrate that a dehiscence in the superior canal can also increase sound-evoked responses in the horizontal canal and otolith organs 8 , 11 , 36 – 38 . Present results indicate this occurs through the same two mechanisms that affect the dehisced canal – vibration delivered by waves, and wave pumping of endolymph.…”

Section: Discussionmentioning

confidence: 83%

Sound abnormally stimulates the vestibular system in canal dehiscence syndrome by generating pathological fluid-mechanical waves

Iversen

Zhu

Zhou

et al. 2018

Sci Rep

View full text Add to dashboard Cite

Individuals suffering from Tullio phenomena experience dizziness, vertigo, and reflexive eye movements (nystagmus) when exposed to seemingly benign acoustic stimuli. The most common cause is a defect in the bone enclosing the vestibular semicircular canals of the inner ear. Surgical repair often corrects the problem, but the precise mechanisms underlying Tullio phenomenon are not known. In the present work we quantified the phenomenon in an animal model of the condition by recording fluid motion in the semicircular canals and neural activity evoked by auditory-frequency stimulation. Results demonstrate short-latency phase-locked afferent neural responses, slowly developing sustained changes in neural discharge rate, and nonlinear fluid pumping in the affected semicircular canal. Experimental data compare favorably to predictions of a nonlinear computational model. Results identify the biophysical origin of Tullio phenomenon in pathological sound-evoked fluid-mechanical waves in the inner ear. Sound energy entering the inner ear at the oval window excites fluid motion at the location of the defect, giving rise to traveling waves that subsequently excite mechano-electrical transduction in the vestibular sensory organs by vibration and nonlinear fluid pumping.

show abstract

Section: Discussionmentioning

confidence: 83%

Sound abnormally stimulates the vestibular system in canal dehiscence syndrome by generating pathological fluid-mechanical waves

Iversen

Zhu

Zhou

et al. 2018

Sci Rep

View full text Add to dashboard Cite

show abstract

“…As a result of a dehiscence in the otic capsule, inner ear biomechanics are altered, such that low-frequency acoustic stimuli of high intensities may create a traveling wave toward the dehiscence, stimulating the vestibular end organs (3, 24). This shunting of acoustic energy creates both a distortion to sound perception, causing hyperacusis and reverberation, and sound- and pressure-evoked vertigo and dizziness (10, 25). …”

Section: Etiologymentioning

confidence: 99%

Superior Canal Dehiscence Syndrome: Lessons from the First 20 Years

2017

Self Cite

View full text Add to dashboard Cite

Superior semicircular canal dehiscence syndrome was first reported by Lloyd Minor and colleagues in 1998. Patients with a dehiscence in the bone overlying the superior semicircular canal experience symptoms of pressure or sound-induced vertigo, bone conduction hyperacusis, and pulsatile tinnitus. The initial series of patients were diagnosed based on common symptoms, a physical examination finding of eye movements in the plane of the superior semicircular canal when ear canal pressure or loud tones were applied to the ear, and high-resolution computed tomography imaging demonstrating a dehiscence in the bone over the superior semicircular canal. Research productivity directed at understanding better methods for diagnosing and treating this condition has substantially increased over the last two decades. We now have a sound understanding of the pathophysiology of third mobile window syndromes, higher resolution imaging protocols, and several sensitive and specific diagnostic tests. Furthermore, we have a treatment (surgical occlusion of the superior semicircular canal) that has demonstrated efficacy. This review will highlight some of the fundamental insights gained in SCDS, propose diagnostic criteria, and discuss future research directions.

show abstract

“…Dehiscence of bone over the superior semicircular canal is the pathologic basis for this syndrome and has been verified in a surgically created animal model of the disorder . Although there have been 3 published reports of acquired dehiscence due to erosion from a neoplasm or osteomyelitis, for all other cases the cause of the dehiscence remains unknown.…”

Section: Introductionmentioning

confidence: 92%

“…Dehiscence of bone over the superior semicircular canal is the pathologic basis for this syndrome and has been verified in a surgically created animal model of the disorder. 2 Although there have been 3 published reports of acquired dehiscence due to erosion from a neoplasm or osteomyelitis, [3][4][5] for all other cases the cause of the dehiscence remains unknown. A recent study 6 found that patients with radiographic superior canal dehiscence were more likely to have had a higher mean body mass index (BMI) (calculated as weight in kilograms divided by height in meters squared) and history of obstructive sleep apnea compared with those without dehiscence.…”

mentioning

confidence: 99%