Superior diagnostic performance of faecal immunochemical tests for haemoglobin in a head-to-head comparison with guaiac based faecal occult blood test among 2235 participants of screening colonoscopy

Brenner, Hermann; Tao, Sha

doi:10.1016/j.ejca.2013.04.023

Cited by 217 publications

(202 citation statements)

References 36 publications

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“…The diagnostic efficacy of AREG was thus comparable with the gFOBT, for which a sensitivity of 33% along with a specificity of 95% has recently been reported in a partly overlapping sample set selected from the BliTz study (8). AREG belongs to the EGF family, which has been suggested to have proneoplastic effects in tissues of a wide variety of organs, such as colon, lung, and stomach, through proinflammatory mechanisms (29,30).…”

Section: Discussionmentioning

confidence: 89%

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Head-to-Head Comparison and Evaluation of 92 Plasma Protein Biomarkers for Early Detection of Colorectal Cancer in a True Screening Setting

Chen

Zucknick

Werner

et al. 2015

Clinical Cancer Research

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Purpose: Novel noninvasive blood-based screening tests are strongly desirable for early detection of colorectal cancer. We aimed to conduct a head-to-head comparison of the diagnostic performance of 92 plasma-based tumor-associated protein biomarkers for early detection of colorectal cancer in a true screening setting.Experimental Design: Among all available 35 carriers of colorectal cancer and a representative sample of 54 men and women free of colorectal neoplasms recruited in a cohort of screening colonoscopy participants in 2005-2012 (N ¼ 5,516), the plasma levels of 92 protein biomarkers were measured. ROC analyses were conducted to evaluate the diagnostic performance. A multimarker algorithm was developed through the Lasso logistic regression model and validated in an independent validation set. The .632þ bootstrap method was used to adjust for the potential overestimation of diagnostic performance.Results: Seventeen protein markers were identified to show statistically significant differences in plasma levels between colorectal cancer cases and controls. The adjusted area under the ROC curves (AUC) of these 17 individual markers ranged from 0.55 to 0.70. An eight-marker classifier was constructed that increased the adjusted AUC to 0.77 [95% confidence interval (CI), 0.59-0.91]. When validating this algorithm in an independent validation set, the AUC was 0.76 (95% CI, 0.65-0.85), and sensitivities at cutoff levels yielding 80% and 90% specificities were 65% (95% CI, 41-80%) and 44% (95% CI, 24-72%), respectively.Conclusions: The identified profile of protein biomarkers could contribute to the development of a powerful multimarker blood-based test for early detection of colorectal cancer.

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Section: Discussionmentioning

confidence: 89%

“…Established noninvasive screening tests are based on stool testing, such as guaiac-based fecal occult blood tests (gFOBT) and fecal immunochemical tests (FIT). However, gFOBTs are limited by low sensitivity (8), and both gFOBTs and FITs face limitations in adherence related to the need of stool collection (9).…”

Section: Introductionmentioning

confidence: 99%

Head-to-Head Comparison and Evaluation of 92 Plasma Protein Biomarkers for Early Detection of Colorectal Cancer in a True Screening Setting

Chen

Zucknick

Werner

et al. 2015

Clinical Cancer Research

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“…12,13,17,19,28,29 The sensitivity and specificity for CRC ranges from 53.3% to 94.1% and 87.5% to 96.9%, respectively. 18,28,30,31 The PPV ranges from 5.2% to 12.8% at a cut-off value of 75 ng/mL. 12,13,[17][18][19][28][29][30][31][32] The NNScreen and NNScope ranges from 213 to 936 and 12,13,17,19,[28][29][30]32 These results are summarised in Table 2.…”

Section: Immunochemical Faecal Occult Blood Testingmentioning

confidence: 69%

“…12,29 In the study by Faivre et al, 32 iFOBT was 1.7 to 2.1 times more sensitive than gFOBT for CRC. 32 A study by Brenner and Tao 30 showed significantly higher PPV for iFOBTs than gFOBTs (7.3%-10.0% vs 4.5%). In two comparative studies, the NNScreen of iFOBT was about half that of gFOBT 29,32 ; iFOBT also had a 13.0% to 15.0% higher participation rate than gFOBT.…”

Section: Immunochemical Faecal Occult Blood Testingmentioning

confidence: 99%

Alternatives to colonoscopy for population-wide colorectal cancer screening

Leung¹,

Foo²,

Chan³

et al. 2016

Hong Kong Med J

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“…[6][7][8][9][10] Fecal immunochemical testing also offers advantages to clinical laboratories, including the potential for automation, the ability to customize the cutoff level to define a positive test, and improved cost-effectiveness. [11][12][13][14][15][16] Finally, by eliminating patients who do not need a colonoscopy, a FIT screening program may be more cost-effective than colonoscopybased screening. 17 Despite the numerous reported advantages of FIT as a screening modality, there are few community-based program evaluations describing the test characteristics of FIT (eg, sensitivity, specificity, and positive predictive value [PPV]) and therefore no data on which to evaluate existing and planned screening programs in Canada.…”

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confidence: 99%

Sensitivity and Specificity of Community Fecal Immunotesting Screening for Colorectal Carcinoma in a High-Risk Canadian Population

Crouse¹,

Koning²,

Sadrzadeh³

et al. 2015

Archives of Pathology &Amp; Laboratory Medicine

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Context.-Community-based programs are a common way of promoting colorectal cancer screening by primary care physicians. Fecal immunochemical testing (FIT) is a screening method commonly used in such programs. Fecal immunochemical testing has advantages to the patient as well as to clinical laboratories.Objective.-To assess the operational test characteristics of a FIT pilot program in Calgary, Alberta, Canada, between April 2011 and May 2012.Design.-Four hundred fifty-seven high-risk patients undergoing both FIT and colonoscopy were included. Areas under the curve and positive predictive values were derived for FIT values and biopsy-proven neoplasia. Subgroup analysis was also performed on men and women and for ages older and younger than the mean age of 62 years.Results.-For colorectal carcinoma and colonic adenomas the areas under the curve were 0.79 (95% confidence interval 0.71-0.87) and 0.60 (95% confidence interval 0.54-0.65), respectively. The positive predictive value of a positive FIT result for any neoplasia was 53%. The overall performance of the test for all neoplasia was better for men and better for older individuals.Conclusions.-The performance of FIT in this clinical setting was very good for detecting carcinoma, but marginal for detection of colonic adenomas.

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Superior diagnostic performance of faecal immunochemical tests for haemoglobin in a head-to-head comparison with guaiac based faecal occult blood test among 2235 participants of screening colonoscopy

Cited by 217 publications

References 36 publications

Head-to-Head Comparison and Evaluation of 92 Plasma Protein Biomarkers for Early Detection of Colorectal Cancer in a True Screening Setting

Head-to-Head Comparison and Evaluation of 92 Plasma Protein Biomarkers for Early Detection of Colorectal Cancer in a True Screening Setting

Alternatives to colonoscopy for population-wide colorectal cancer screening

Sensitivity and Specificity of Community Fecal Immunotesting Screening for Colorectal Carcinoma in a High-Risk Canadian Population

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