Superior Graft-versus-Host Disease-Free Relapse-Free Survival in Matched Unrelated Donor Hematopoietic Stem Cell Transplantation with Anti-Thymocyte Globulin (ATG) Compared to Matched Related Donor without ATG

Remberger, Mats; Tjønnfjord, Geir E.; Abrahamsen, Ingerid Weum; Ali, Maryan; Myhre, Anne Grethe; Gedde‐Dahl, Tobias; Fløisand, Yngvar

doi:10.1016/j.jtct.2021.03.019

Cited by 3 publications

(2 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…While patients with in vivo T-cell depletion using ATG show reduced incidence of acute or chronic GVHD, without increasing mortality and affecting overall survival ( 28 ). Many studies conducted in Europe and Australia have proved that compared with HLA-matched sibling transplantation, the occurrence of chronic GVHD was lower in URD-HSCT with ATG ( 29 , 30 ). Thus, the correlation between the selection of donor and the occurrence and severity of oGVHD needs to be further studied on the premise of controlling precondition before transplantation.…”

Section: Discussionmentioning

confidence: 99%

Correlative factors of ocular surface lesions after allogeneic hematopoietic stem cell transplantation: A retrospective study

Zhuang

Sun

et al. 2022

Front. Oncol.

View full text Add to dashboard Cite

BackgroundOcular graft-versus-host disease (oGVHD) is one of the complications after allogeneic hematopoietic stem cell transplantation (HSCT), which impairs the quality of life and may indicate poor prognosis. In this retrospective study, the aim was to investigate the characteristics of ocular surface after HSCT, and analyze the risk factors related to the severity of ocular surface lesions.Methods248 post-HSCT patients were enrolled in this retrospective study. Subjects were divided into no lesion group, mild lesion group and severe lesion group, according to the severity of ocular surface lesions. The correlations between grades of ocular surface lesions and gender, age, primary disease, donor source, human leukocyte antigen (HLA) type, kinship, donor-recipient relationship, blood type, source of stem cell and systemic GVHD were analyzed.ResultsThe median scores of corneal epitheliopathy, lid margin lesions and meibomian gland loss were 3, 6 and 2 points, respectively. The grade of corneal epitheliopathy was related to donor source (P<0.001), kinship (P=0.033), HLA-matching (P<0.001), and systemic GVHD (P=0.007), especially oral GVHD (P<0.001) and liver GVHD (P=0.002). The grade of lid margin lesions was related to donor source (P=0.019), HLA-matching (P=0.006), and systemic GVHD (P=0.013), especially skin GVHD (P=0.019) and oral GVHD (P=0.019). The grade of meibomian gland loss was related to age (P=0.035) and gastrointestinal GVHD (P=0.007). The grade of corneal epitheliopathy after HSCT was related to the lid margin lesion score (P<0.001).ConclusionsThe occurrence and development of ocular GVHD are mostly accompanied by the history of systemic GVHD. While in few cases, ocular surface lesions related to GVHD can be observed prior to the rejection of other tissues and organs. Severe corneal epitheliopathy occurs in patients with severe lid margin lesions in ocular GVHD. The lesions of corneal epithelium and lid margin are milder in HLA partially matching transplantation.

show abstract

Section: Discussionmentioning

confidence: 99%

Correlative factors of ocular surface lesions after allogeneic hematopoietic stem cell transplantation: A retrospective study

Zhuang

Sun

et al. 2022

Front. Oncol.

View full text Add to dashboard Cite

show abstract

“…En balansert reduksjon av donor-T-celler er nødvendig for å oppre holde antileukemisk effekt og samtidig forhindre transplantat-mot-vert-sykdom (9). Totaldose på 4-6 mg/kg er vist å effektivt redusere transplantat-mot-vert-sykdom uten samtidig å øke risiko for tilbakefall (10,11). Selv om frekvensen av kronisk transplantat-motvert-sykdom er redusert og på nivå med andre studier, er y erligere reduksjon ønskelig grunnet redusert livskvalitet assosiert med sykdommen.…”

Section: Diskusjonunclassified

Allogeneic stem cell transplantation in adults 2015–21

Vo¹,

Myhre²,

Abrahamsen³

et al. 2023

Tidsskriftet

View full text Add to dashboard Cite

show abstract

Low incidence of severe acute and chronic graft-versus-host disease in a long-term retrospective study with ATG Grafalon routine use

Kovacsova,

Folber,

Weinbergerova

et al. 2023

Ann Hematol

View full text Add to dashboard Cite

Since 2006, combined graft-versus-host disease (GVHD) prophylaxis with ATG Grafalon has been our department’s base of peri-transplant supportive care. This recent retrospective study included 398 patients who underwent their first allogeneic hematopoietic stem cell transplantation after receiving a defined dose of ATG Grafalon. Our observations recorded reduced incidence of severe acute and chronic GVHD without negative impact on overall survival in a nonselected group with standard and uniform GVHD prophylaxis.

show abstract

Superior Graft-versus-Host Disease-Free Relapse-Free Survival in Matched Unrelated Donor Hematopoietic Stem Cell Transplantation with Anti-Thymocyte Globulin (ATG) Compared to Matched Related Donor without ATG

Cited by 3 publications

References 3 publications

Correlative factors of ocular surface lesions after allogeneic hematopoietic stem cell transplantation: A retrospective study

Correlative factors of ocular surface lesions after allogeneic hematopoietic stem cell transplantation: A retrospective study

Allogeneic stem cell transplantation in adults 2015–21

Low incidence of severe acute and chronic graft-versus-host disease in a long-term retrospective study with ATG Grafalon routine use

Contact Info

Product

Resources

About