Superior mesenteric artery calcification is associated with cardiovascular risk factors, systemic calcified atherosclerosis, and increased mortality

Lin, Timothy C; Wright, C. Michael; Criqui, Michael H.; Allison, Matthew

doi:10.1016/j.jvs.2017.08.081

Cited by 19 publications

(18 citation statements)

References 9 publications

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“…However, different studies show that the presence of calcifications in the celiac trunk or in the superior mesenteric artery correlates with systemic calcified atherosclerosis, cardiovascular risk factors, all-cause mortality, and fatty liver. This could be in favor of an atherosclerotic process in these arteries [14,31,32].…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, it has been known for more than a century that atherosclerosis and other vascular anomalies are more often seen in the intrapancreatic vessels of patients with diabetes than in control subjects [12,13]. A recent study showed that the extent of calcifications in the superior mesenteric artery associates with the presence of diabetes [14]. In a postmortem angiography study, it was shown that vascular anomalies are more often seen in patients with type 2 diabetes than in control subjects, independently from the duration of diabetes [15].…”

Section: Introductionmentioning

confidence: 99%

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Patients with type 2 diabetes present with multiple anomalies of the pancreatic arterial tree on abdominal computed tomography: comparison between patients with type 2 diabetes and a matched control group

Alexandre‐Heymann

Barral

Dohan

et al. 2020

Cardiovasc Diabetol

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Background: Studies suggest that cardio-vascular risk factors could foster the development of type 2 diabetes (T2D). This could partly be mediated by pancreatic atherosclerosis resulting in pancreatic ischemia. We hypothesized that patients with T2D present with more severe atherosclerosis of pancreas-bound arteries than control patients without T2D. Methods: We performed a retrospective study comparing the abdominal computed tomography of patients with T2D and of control subjects matched for gender and for age. We performed a multivariate logistic regression with adjustment for age, gender, BMI and the presence or absence of hypertension. Results: Forty-eight patients with T2D and 48 control subjects were included. A calcification score of the splenic artery was defined (from 0: no calcification to 3: continuous linear calcifications). Seventeen percent of the patients with T2D presented with a high calcification score (i.e. 2 or 3), versus only 2% of the control subjects (p = 0.04). The mean number of pancreas-bound branches among the greater pancreatic artery, dorsal pancreatic artery and inferior pancreatic artery (from 0 to 3) was lower in patients with T2D than in control subjects (1.1 vs 1.7, p = 0.003). The mean number of visible intrapancreatic arterial subdivisions (from 0 to 2) was lower in patients with T2D than in control subjects (0.7 vs 1.3, p = 0.0017). All these differences hold true using multivariate logistic regression. None of these differences correlated with the duration of diabetes. The relationship between pancreas volume and BMI seen in control subjects was not confirmed in patients with T2D. Conversely, in patients with T2D but not in control subjects, the splenic artery diameter correlated with the pancreas volume. Conclusions: Patients with T2D present with more calcifications of the splenic artery and with a less dense pancreatic arterial tree than control subjects.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Patients with type 2 diabetes present with multiple anomalies of the pancreatic arterial tree on abdominal computed tomography: comparison between patients with type 2 diabetes and a matched control group

Alexandre‐Heymann

Barral

Dohan

et al. 2020

Cardiovasc Diabetol

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“…Among our study participants, coronary calcification co-occurred with atherosclerotic plaques in the carotid and/or femoral arteries in 87.8% in close agreement with the previous result. About more generalized arterial calcification one study found that calcification of the superior mesenteric artery was significantly associated with the calcification of five other arterial territories (celiac trunk, coronaries, thoracic aorta, abdominal aorta, and iliac arteries) on CT [ 35 ]. Another study found that more than two-thirds of patients over 70 years old showed generalized arterial calcification in all investigated arteries (carotid, coronary, aorta, iliac arteries) and calcified atherosclerotic plaques significantly correlated in different vascular beds [ 36 ].…”

Section: Discussionmentioning

confidence: 99%

Overlapping Genetic Background of Coronary Artery and Carotid/Femoral Atherosclerotic Calcification

et al. 2021

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Background and objectives: Multivessel atherosclerosis and its genetic background are under-investigated, although atherosclerosis is seldom local and still causes high mortality. Alternative methods to assess coronary calcification (CAC) might incorporate genetic links between different arteries’ atherosclerotic involvement, however, co-occurrences of coronary calcification have not been investigated in twins yet. Materials and Methods: We assessed the heritability of radio morphologically distinct atherosclerotic plaque types in coronary (non-enhanced CT, Agatston score), carotid, and femoral arteries (B-mode ultrasound) in 190 twin subjects (60 monozygotic, 35 dizygotic pairs). Four-segment scores were derived in order to assess the dissemination of the distinct plaque types in the carotid and femoral arteries taking bilaterality into account. We calculated the genetic correlation between phenotypically correlating plaque types in these arteries. Results: CAC and dissemination of calcified plaques in the carotid and femoral arteries (4S_hyper) were moderately heritable (0.67 [95% CI: 0.37–1] and 0.69 [95% CI: 0.38–1], respectively) when adjusted for age and sex. Hypoechoic plaques in the carotid and femoral arteries showed no heritability, while mixed plaques showed intermediate heritability (0.50 [95% CI: 0–0.76]). Age and sex-adjusted phenotypic correlation between CAC and 4segm_hyper was 0.48 [95% CI: 0.30–0.63] and the underlying genetic correlation was 0.86 [95% CI: 0.42–1]. Conclusions: Calcification of atherosclerotic plaques is moderately heritable in all investigated arteries and significant overlapping genetic factors can be attributed to the phenotypical resemblance of coronary and carotid or femoral atherosclerotic calcification. Our findings support the idea of screening extracoronary arteries in asymptomatic individuals. We also propose a hypothesis about primarily carotid-coronary and femoral-coronary atherosclerosis as two distinct genetic predispositions to co-localization.

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“…Lin et al had previously reported that the SMA calcification has a strong association with major cardiovascular risk factors, cardiovascular mortality, and all-cause mortality. 17 Renal artery calcification had also been shown to have strong association with all-cause mortality in healthy individuals, independent of traditional cardiac risk factors. 18 Both studies were performed on a healthy population with no known cardiovascular disease.…”

Section: Discussionmentioning

confidence: 99%

Association Between Abdominal Visceral Artery Calcification and All-Cause Mortality—A Computerized Tomography Imaging-Based Longitudinal Follow-Up Study

et al. 2018

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Arterial calcification in different arterial beds has been observed to be an independent predictor of mortality. The association of abdominal visceral artery calcium with all-cause mortality remains unexplored. Patients who had undergone contrast-enhanced computerized tomography (CT) imaging for routine assessment of peripheral arterial disease (PAD) were considered for this study. A novel calcium score (abdominal visceral arteries calcium [AVAC]) for the abdominal visceral arteries (celiac axis, superior mesenteric, and renal arteries) was calculated using a modified Agatston score. Cumulative AVAC was defined as sum total of the calcium score of above individual arteries. The primary outcome was all-cause mortality. The association of AVAC with all-cause mortality was assessed. Of the 134 consecutive patients, 89 were included for analysis. Median follow-up duration was 72 (47-91) months since CT imaging; 35 (39%) patients died during this period. Hypertension and cumulative AVAC score had a significant association with all-cause mortality ( P < .05). Cumulative visceral abdominal artery calcification is associated with all-cause mortality in patients with PAD. Future prospective studies are warranted to investigate this relationship in PAD and other patient cohorts.

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Superior mesenteric artery calcification is associated with cardiovascular risk factors, systemic calcified atherosclerosis, and increased mortality

Cited by 19 publications

References 9 publications

Patients with type 2 diabetes present with multiple anomalies of the pancreatic arterial tree on abdominal computed tomography: comparison between patients with type 2 diabetes and a matched control group

Patients with type 2 diabetes present with multiple anomalies of the pancreatic arterial tree on abdominal computed tomography: comparison between patients with type 2 diabetes and a matched control group

Overlapping Genetic Background of Coronary Artery and Carotid/Femoral Atherosclerotic Calcification

Association Between Abdominal Visceral Artery Calcification and All-Cause Mortality—A Computerized Tomography Imaging-Based Longitudinal Follow-Up Study

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