Superior muscle reinnervation after autologous nerve graft or poly-L-lactide-?-caprolactone (PLC) tube implantation in comparison to silicone tube repair

Valero‐Cabré, Antoni; Tsironis, K.; Skouras, Emmanouil; Perego, G.; Navarro, Xavier; Neiss, Wolfram F.

doi:10.1002/1097-4547(20010115)63:2<214::aid-jnr1014>3.0.co;2-d

Cited by 106 publications

(64 citation statements)

References 44 publications

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“…Substantially larger segmental defects could be reconstructed, and the morbidity of harvesting would be eliminated. Several types of materials have been proposed as peripheral nerve substitutes [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15], including autologous materials such as vein and muscle strips, synthetic materials such as polylactic acid and polyglycolic acid, non-autologous biological materials such as acellular peripheral nerve allograft, and conduits made of collagen, laminin, fibronectin, and alginate.…”

Section: Introductionmentioning

confidence: 62%

Mechanical properties of acellular peripheral nerve

Borschel

Kia

Kuzon

et al. 2003

Journal of Surgical Research

243

165

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Background. Acellular nerve has been used in experimental models as a peripheral nerve substitute. Our objective was to determine the difference in tensile strength between fresh and chemically treated acellularized peripheral nerve.Materials and methods. F344 rat sciatic nerves were either fresh or acellularized and tested either whole (Part A) or transected and repaired (Part B). For all constructs, the mean ultimate stress, mean ultimate strain, Young's modulus, and total mechanical work to fracture were calculated.Results Conclusions. Although adequately robust for reconstructive procedures, the acellular peripheral nerve had decreased tensile strength compared with fresh nerve either when tested whole or when transected and repaired.

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Section: Introductionmentioning

confidence: 62%

Mechanical properties of acellular peripheral nerve

Borschel

Kia

Kuzon

et al. 2003

Journal of Surgical Research

243

165

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“…A loss of about 20 to 30% hypoglossal motoneurones (Snider and Thanedar, 1989;Törnqvist and Aldskogius, 1994) and facial motoneurones (Yu, 1988;Mattson et al, 1998) was described after cranial nerve section in adult rats. Several authors found a non-significant loss of about 10% motoneurones after sciatic nerve injury (Vanden-Noven et al, 1993;Lowrie et al, 1994;Valero-Cabré et al, 2001) and no changes with respect to the contralateral side was found after section and repair of the rat femoral nerve (Al-Majed et al, 2000).…”

Section: Labelling With the First Tracer: Neuronal Death Versus Tracementioning

confidence: 99%

“…To obtain optimal results, it is important to choose the tracer best suited for the system studied and for the specific question asked. The differences in characteristics between tracers also makes it possible to combine several dyes in the same experiment, for instance to identify neurones with dual projections by applying different retrograde tracers in the two projection areas and look for double labelled neurones (Angelov et al, 1999;Valero-Cabré et al, 2001). Double labelling models with different retrograde tracers have been used to study regeneration and the topographical accuracy of reinnervation after peripheral nerve injury.…”

Section: Introductionmentioning

confidence: 99%

On the use of fast blue, fluoro-gold and diamidino yellow for retrograde tracing after peripheral nerve injury: uptake, fading, dye interactions, and toxicity

Puigdellı́vol-Sánchez

Valero‐Cabré

Prats-Galino

et al. 2002

Journal of Neuroscience Methods

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The usefulness of three retrograde fluorescent dyes for tracing injured peripheral axons was investigated. The rat sciatic was transected bilaterally and the proximal end briefly exposed to either Fast Blue (FB), Fluoro-Gold (FG) or to Diamidino Yellow (DY) on the right side, and to saline on the left side, respectively. The nerves were then resutured and allowed to regenerate.Electrophysiological tests three months later showed similar latencies and amplitudes of evoked muscle and nerve action potentials between tracer groups. The nerves were then cut distal to the original injury and exposed to a second (different) dye. Five days later, retrogradely labelled neurones were counted in the dorsal root ganglia (DRGs) and spinal cord ventral horn. The number of neurones labelled by the first tracer was similar for all three dyes in the DRG and ventral horn except for FG, which labelled fewer motoneurones. When used as second tracer, DY labelled fewer neurones than FG and FB in some experimental situations. The total number of neurones labelled by the first and/or second tracer was reduced by about 30% compared to controls. The contributions of cell death as well as different optional tracer combinations for studies of nerve regeneration are discussed.

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“…In general, the percentage of DRG sensory neuron death varies between 5 and 30%, and the death rate of motoneurons amounts to 0~10% (Arvidsson et al, 1986;Groves et al, 2003;Lowrie et al, 1994;Tandrup et al, 2000;Valero-Cabre et al, 2001;Vanden et al, 1993;Vestergaard et al, 1997).…”

Section: Gdf-15 and Regenerated Axonsmentioning

confidence: 99%