Superior Pedicle Mammaplasty without Parenchymal Incisions after Massive Weight Loss

2020

Medicina

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Background and objectives: Breast cancer treatment has deeply changed in the last fifty years. Acellular dermal matrices (ADMs) were introduced for breast reconstruction, with encouraging results, but with conflicting reports too. The present paper aims to summarize the current data on breast reconstruction using acellular dermal matrices. Materials and Methods: We reviewed the literature regarding the use of ADM-assisted implant-based breast reconstruction. Results: The main techniques were analyzed and described. Conclusions: Several authors have recently reported positive results. Nevertheless, an increased complications’ rate has been reported by other authors. Higher cost compared to not-ADM-assisted breast reconstruction is another concern.

Section: Resultsmentioning

confidence: 99%

Submuscular and Pre-pectoral ADM Assisted Immediate Breast Reconstruction: A Literature Review

2020

Medicina

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“…At the same time, this set of cells and growth factors up‐regulate the ki‐67 pathway in the wound, in order to promote the cellular proliferation 33,35,36 . These evidences suggested that injection of filtered fat graft improves wound healing, but the correlation with pain reduction is less clear 18,19,37‐39 …”

Section: Discussionmentioning

confidence: 99%

Fat graft for reducing pain in chronic wounds

Wound Repair Regeneration

Giardino

Nisi

et al. 2020

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Background Chronic wounds are one of the most important challenge for regenerative surgery. Plastic surgeon can use fat graft to increase wound healing because its growth factors can enhance tissue regeneration. In a recent study, the authors evaluated a reduction of pain in a cohort of patients submitted to breast reconstruction with breast implant and lipofilling, putting into evidence that growth factors in fat graft can reduce post‐surgical pain. The aim of this work is to evaluate ultra‐filtered fat graft potential in reducing pain in chronic wounds. Patients and Methods Fifty new patients with chronic wounds of different etiology were recruited for this study and divided into two groups: A, treatment and B, control. Twenty‐five patients per group. Negative pressure therapy dressing was applied after surgical debridement. Three days later patients in group A received ultrafiltered fat graft. Pain was evaluated with preoperative Visual Analogic Scale, repeated twice a day for 14 days and finally 21 days from procedures. Results In group A (treated patients), pain was lower. These data were confirmed even after 7 days. The overall statistical analysis of the average of all values (SD 1.72) confirmed that the differences were significant at the 95% with the Chi‐square test and analysis of variance (P value < .05). Conclusions The ultra‐filtered fat graft placed on the wound bed and edges was effective in reducing pain in chronic wounds. The reduction of pain was statistically significant.

“…The prognosis of this cancer is good when detected in an early stage and treated adequately, with risk of death less than 5%, lower than other malignancies [ 14 ]. Despite many years of research, the etiopathogenetic mechanisms responsible for it remain poorly understood [ 1 , 15 , 16 , 17 , 18 , 19 ]. Many researches theorize a role of bacterial biofilm around the implant: this leads to chronic inflammation and, successively, to capsule contracture [ 3 ] and/or BIA-ALCL.…”

Section: Introductionmentioning

confidence: 99%

The State of the Art about Etiopathogenetic Models on Breast Implant Associated–Anaplastic Large Cell Lymphoma (BIA-ALCL): A Narrative Review

2021

JCM

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Background: Breast-implant-associated anaplastic large cell lymphoma is a rare malignancy linked to texturized breast implants. Although many researchers focus on its etiopathogenesis, this topic is affected by a lack of evidence. Materials and Methods: A literature review about BIA-ALCL was made. Results and conclusions: Although the incidence is reported between 1:355–1:30,000, there is great attention to BIA-ALCL. The incidence is uncertain due to many reasons. It may well be lower, due to inclusion in multiple databases as pointed out by the FDA and undiagnosed cases. The role of chronic inflammation, bacterial contamination, and mechanical forces was discussed. Clarification is needed to understand the mechanisms underlying the progression of alterations and mutations for BIA-ALCL; new molecular analysis and pathogenetic models should be investigated.