Coincidence Doppler Broadening Spectroscopy (CDBS) was employed to analyze ten simple oxides and compare them to their corresponding non-oxidized pure elements to identify the spectral signature attributable to oxygen. Despite variations among the oxidized elements, the resulting spectra exhibited consistent features—when referenced against the oxidized elements—that can be attributed to oxygen. Furthermore, CDBS spectra referenced against pure aluminum, a widely used independent standard, also revealed a prominent characteristic signal indicative of oxygen that can serve as a fingerprint for its presence. Comparisons with CDBS spectra of Group XVIa elements (Te, Se, and S) were also conducted to further validate the oxygen-related features. This methodology offers a valuable approach for discerning oxygen contributions in complex materials, even when the CDBS spectra are intricate and involve diverse compositions.